FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113159898> ?p ?o ?g. }

• W2113159898 endingPage "5973" @default.
• W2113159898 startingPage "5966" @default.
• W2113159898 abstract "Apoptosis of peripheral blood T cells plays an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. In this study, we found that HIV type 1 (HIV-1) primes CD4(+) T cells from healthy donors for apoptosis, which occurs after CD95 ligation or CD3-T-cell receptor (TCR) stimulation. CD95-mediated death did not depend on CD4 T-cell infection, since it occurred in the presence of the reverse transcriptase inhibitor didanosine (ddI). In contrast, apoptosis induced by productive infection (CD3-TCR stimulation) is prevented by both CD95 decoy receptor and ddI. Our data suggest that HIV-1 triggers at least two distinct death pathways: a CD95-dependent pathway that does not require viral replication and a viral replication-mediated cell death independent of the CD95 pathway. Further experiments indicated that saquinavir, a protease inhibitor, at a 0.2 microM concentration, decreased HIV-mediated CD95 expression and thus cell death, which is independent of its role in inhibiting viral replication. However, treatment of peripheral blood mononuclear cells from healthy donors with a higher concentration (10 microM) of an HIV protease inhibitor, saquinavir or indinavir, induced both a loss in mitochondrial membrane potential (DeltaPsim) and cell death. Thus, protease inhibitors have the potential for both beneficial and detrimental effects on CD4(+) T cells independent of their antiretroviral effects." @default.
• W2113159898 created "2016-06-24" @default.
• W2113159898 creator A5008649323 @default.
• W2113159898 creator A5013917588 @default.
• W2113159898 creator A5018390497 @default.
• W2113159898 creator A5035001405 @default.
• W2113159898 creator A5059162808 @default.
• W2113159898 creator A5063249733 @default.
• W2113159898 creator A5073322790 @default.
• W2113159898 creator A5091079663 @default.
• W2113159898 date "2002-06-15" @default.
• W2113159898 modified "2023-10-16" @default.
• W2113159898 title "Effects of Antiretroviral Drugs on Human Immunodeficiency Virus Type 1-Induced CD4⁺T-Cell Death" @default.
• W2113159898 cites W140238039 @default.
• W2113159898 cites W146744780 @default.
• W2113159898 cites W1493428938 @default.
• W2113159898 cites W1522774640 @default.
• W2113159898 cites W1540507088 @default.
• W2113159898 cites W1596483199 @default.
• W2113159898 cites W1745634660 @default.
• W2113159898 cites W1759299744 @default.
• W2113159898 cites W1871950822 @default.
• W2113159898 cites W1936431025 @default.
• W2113159898 cites W1965874822 @default.
• W2113159898 cites W1967239571 @default.
• W2113159898 cites W1970833400 @default.
• W2113159898 cites W1974393084 @default.
• W2113159898 cites W197495146 @default.
• W2113159898 cites W1976991579 @default.
• W2113159898 cites W1987138081 @default.
• W2113159898 cites W1989364014 @default.
• W2113159898 cites W2002581043 @default.
• W2113159898 cites W2006327082 @default.
• W2113159898 cites W2012139740 @default.
• W2113159898 cites W2018793167 @default.
• W2113159898 cites W2022297632 @default.
• W2113159898 cites W2023833143 @default.
• W2113159898 cites W2024789710 @default.
• W2113159898 cites W2026545608 @default.
• W2113159898 cites W2030127456 @default.
• W2113159898 cites W2043043678 @default.
• W2113159898 cites W2056169141 @default.
• W2113159898 cites W2057441539 @default.
• W2113159898 cites W2061786750 @default.
• W2113159898 cites W2063950143 @default.
• W2113159898 cites W2072539657 @default.
• W2113159898 cites W2077911026 @default.
• W2113159898 cites W2078326422 @default.
• W2113159898 cites W2080375720 @default.
• W2113159898 cites W2080786231 @default.
• W2113159898 cites W2083930032 @default.
• W2113159898 cites W2088787526 @default.
• W2113159898 cites W2091483427 @default.
• W2113159898 cites W2111935751 @default.
• W2113159898 cites W2114654929 @default.
• W2113159898 cites W2114968909 @default.
• W2113159898 cites W2122832461 @default.
• W2113159898 cites W2123575047 @default.
• W2113159898 cites W2127215056 @default.
• W2113159898 cites W2148845605 @default.
• W2113159898 cites W2153536035 @default.
• W2113159898 cites W2155225796 @default.
• W2113159898 cites W2167294566 @default.
• W2113159898 cites W2170178225 @default.
• W2113159898 cites W2171662872 @default.
• W2113159898 cites W2227001432 @default.
• W2113159898 cites W2312973323 @default.
• W2113159898 cites W2322485212 @default.
• W2113159898 cites W2329393410 @default.
• W2113159898 cites W2339219218 @default.
• W2113159898 cites W2339827976 @default.
• W2113159898 cites W2414676408 @default.
• W2113159898 cites W39416069 @default.
• W2113159898 cites W4251307042 @default.
• W2113159898 cites W4255922514 @default.
• W2113159898 cites W64205557 @default.
• W2113159898 doi "https://doi.org/10.1128/jvi.76.12.5966-5973.2002" @default.
• W2113159898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/136220" @default.
• W2113159898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12021329" @default.
• W2113159898 hasPublicationYear "2002" @default.
• W2113159898 type Work @default.
• W2113159898 sameAs 2113159898 @default.
• W2113159898 citedByCount "70" @default.
• W2113159898 countsByYear W21131598982012 @default.
• W2113159898 countsByYear W21131598982013 @default.
• W2113159898 countsByYear W21131598982014 @default.
• W2113159898 countsByYear W21131598982016 @default.
• W2113159898 countsByYear W21131598982017 @default.
• W2113159898 countsByYear W21131598982018 @default.
• W2113159898 countsByYear W21131598982019 @default.
• W2113159898 countsByYear W21131598982020 @default.
• W2113159898 countsByYear W21131598982021 @default.
• W2113159898 crossrefType "journal-article" @default.
• W2113159898 hasAuthorship W2113159898A5008649323 @default.
• W2113159898 hasAuthorship W2113159898A5013917588 @default.
• W2113159898 hasAuthorship W2113159898A5018390497 @default.
• W2113159898 hasAuthorship W2113159898A5035001405 @default.
• W2113159898 hasAuthorship W2113159898A5059162808 @default.

• next