FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113160480> ?p ?o ?g. }

• W2113160480 endingPage "2643" @default.
• W2113160480 startingPage "2625" @default.
• W2113160480 abstract "Interim findings of a clinical trial often will be useful for increasing the sample size if necessary to provide the required power against the null hypothesis when the alternative hypothesis is true. Strategies for carrying out the interim examination that have been described over the past several years include internal pilot studies, blinded interim sample size adjustment and conditional power. Simulation studies show that the alternative methods generally control the type I error rate satisfactorily, although the power properties are more variable. The important issues associated with sample size re-estimation are strategic, not numeric. Clearly expressed regulatory preferences suggest that methods not requiring unblinding the data before completion of the trial would be most appropriate. Extending a trial has its risks. The investigators/patients enrolled later in the course of a trial are not necessarily the same as those recruited/entered early. Re-activating the enrollment process may be sufficiently complicated and expensive to justify enrolling more investigators/patients at the outset. Since sample size re-estimation adjusts the sample size on the basis of variability while efficacy interim analysis adjusts the sample size based on the basis of estimated effect size, both principles can be used in the same trial. Sample size re-estimation may not be advisable for trials involving extended follow-up of individual patients or, more generally, when the follow-up time is long relative to the recruitment time. In such cases, it may be better to estimate the sample size conservatively and introduce an interim efficacy evaluation." @default.
• W2113160480 created "2016-06-24" @default.
• W2113160480 creator A5044996588 @default.
• W2113160480 date "2001-08-14" @default.
• W2113160480 modified "2023-10-16" @default.
• W2113160480 title "Sample size re-estimation: recent developments and practical considerations" @default.
• W2113160480 cites W1970653245 @default.
• W2113160480 cites W1978262690 @default.
• W2113160480 cites W1979041225 @default.
• W2113160480 cites W1980720473 @default.
• W2113160480 cites W1985021805 @default.
• W2113160480 cites W1986502618 @default.
• W2113160480 cites W2001813522 @default.
• W2113160480 cites W2007761046 @default.
• W2113160480 cites W2017011036 @default.
• W2113160480 cites W2021045328 @default.
• W2113160480 cites W2030290198 @default.
• W2113160480 cites W2034478315 @default.
• W2113160480 cites W2036379170 @default.
• W2113160480 cites W2038923647 @default.
• W2113160480 cites W2040929775 @default.
• W2113160480 cites W2042819373 @default.
• W2113160480 cites W2048382391 @default.
• W2113160480 cites W2055750917 @default.
• W2113160480 cites W2062927025 @default.
• W2113160480 cites W2069026165 @default.
• W2113160480 cites W2069213989 @default.
• W2113160480 cites W2077597832 @default.
• W2113160480 cites W2088018369 @default.
• W2113160480 cites W2088238660 @default.
• W2113160480 cites W2090824711 @default.
• W2113160480 cites W2095536747 @default.
• W2113160480 cites W2112501614 @default.
• W2113160480 cites W2119762627 @default.
• W2113160480 cites W2127242548 @default.
• W2113160480 cites W2129512582 @default.
• W2113160480 cites W2132133618 @default.
• W2113160480 cites W2139123180 @default.
• W2113160480 cites W2140616079 @default.
• W2113160480 cites W2142825496 @default.
• W2113160480 cites W2146671770 @default.
• W2113160480 cites W2165367494 @default.
• W2113160480 cites W2168842026 @default.
• W2113160480 cites W2171991128 @default.
• W2113160480 cites W4238685868 @default.
• W2113160480 doi "https://doi.org/10.1002/sim.733" @default.
• W2113160480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11523073" @default.
• W2113160480 hasPublicationYear "2001" @default.
• W2113160480 type Work @default.
• W2113160480 sameAs 2113160480 @default.
• W2113160480 citedByCount "97" @default.
• W2113160480 countsByYear W21131604802012 @default.
• W2113160480 countsByYear W21131604802013 @default.
• W2113160480 countsByYear W21131604802014 @default.
• W2113160480 countsByYear W21131604802015 @default.
• W2113160480 countsByYear W21131604802016 @default.
• W2113160480 countsByYear W21131604802017 @default.
• W2113160480 countsByYear W21131604802018 @default.
• W2113160480 countsByYear W21131604802019 @default.
• W2113160480 countsByYear W21131604802020 @default.
• W2113160480 countsByYear W21131604802021 @default.
• W2113160480 countsByYear W21131604802022 @default.
• W2113160480 countsByYear W21131604802023 @default.
• W2113160480 crossrefType "journal-article" @default.
• W2113160480 hasAuthorship W2113160480A5044996588 @default.
• W2113160480 hasConcept C105795698 @default.
• W2113160480 hasConcept C126322002 @default.
• W2113160480 hasConcept C129848803 @default.
• W2113160480 hasConcept C149782125 @default.
• W2113160480 hasConcept C162324750 @default.
• W2113160480 hasConcept C166957645 @default.
• W2113160480 hasConcept C185592680 @default.
• W2113160480 hasConcept C187736073 @default.
• W2113160480 hasConcept C191988596 @default.
• W2113160480 hasConcept C198531522 @default.
• W2113160480 hasConcept C2776957806 @default.
• W2113160480 hasConcept C33923547 @default.
• W2113160480 hasConcept C40696583 @default.
• W2113160480 hasConcept C41008148 @default.
• W2113160480 hasConcept C43617362 @default.
• W2113160480 hasConcept C535046627 @default.
• W2113160480 hasConcept C61943457 @default.
• W2113160480 hasConcept C71924100 @default.
• W2113160480 hasConcept C95457728 @default.
• W2113160480 hasConcept C96250715 @default.
• W2113160480 hasConceptScore W2113160480C105795698 @default.
• W2113160480 hasConceptScore W2113160480C126322002 @default.
• W2113160480 hasConceptScore W2113160480C129848803 @default.
• W2113160480 hasConceptScore W2113160480C149782125 @default.
• W2113160480 hasConceptScore W2113160480C162324750 @default.
• W2113160480 hasConceptScore W2113160480C166957645 @default.
• W2113160480 hasConceptScore W2113160480C185592680 @default.
• W2113160480 hasConceptScore W2113160480C187736073 @default.
• W2113160480 hasConceptScore W2113160480C191988596 @default.
• W2113160480 hasConceptScore W2113160480C198531522 @default.
• W2113160480 hasConceptScore W2113160480C2776957806 @default.
• W2113160480 hasConceptScore W2113160480C33923547 @default.
• W2113160480 hasConceptScore W2113160480C40696583 @default.

• next