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- W2113161868 abstract "We examined whether xanthine oxidase (XO)-derived reactive oxygen species (ROS) contribute to the development of d-galactosamine (d-GaIN)-induced liver injury in rats. In rats treated with d-GaIN (500 mg/kg), liver injury appeared 6 h after treatment and developed until 24 h. Hepatic XO and myeloperoxidase activities increased 12 and 6 h, respectively, after d-GalN treatment and continued to increase until 24 h. d-GalN-treated rats had increased hepatic lipid peroxide (LPO) content and decreased hepatic reduced glutathione (GSH) and ascorbic acid contents and superoxide dismutase (SOD), catalase and Se-glutathione peroxidase (Se-GSHpx) activities at 24 h, but not 6 h, after treatment. Allopurinol (10, 25 or 50 mg/kg) administered at 6 h after d-GalN treatment attenuated not only the advanced liver injury and increased hepatic XO activity but also all other changes observed at 24 h after the treatment dose-dependently. These results suggest that XO-derived ROS contribute to the development of d-GaIN-induced liver injury in rats." @default.
- W2113161868 created "2016-06-24" @default.
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- W2113161868 date "2007-01-01" @default.
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- W2113161868 title "Xanthine oxidase-derived reactive oxygen species contribute to the development of<scp>d</scp>-galactosamine-induced liver injury in rats" @default.
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- W2113161868 doi "https://doi.org/10.1080/10715760600953842" @default.
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