FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113163706> ?p ?o ?g. }

• W2113163706 endingPage "8" @default.
• W2113163706 startingPage "4922" @default.
• W2113163706 abstract "2-Methyl-1,4-naphthoquinone, vitamin K(3) (menadione), which is frequently used as a model quinone in cell culture and in vivo studies, was tested for its effects on gap-junctional intercellular communication (GJC). Exposure of WB-F344 rat liver epithelial cells to menadione (50-100 micro M) led to a 50-75% decrease in GJIC. Different from the phorbol ester 12-O-tetradecanoylphorbol 13-acetate, menadione did not induce internalization of gap junctions. Rather, the decreased GJIC was found to be because of phosphorylation of connexin 43, the major connexin in the used cell line, which was mediated by MAPK/ERK kinase (MEK) 1 and MEK 2 as well as by activation of their direct substrates, extracellular signal-regulated kinase (ERK) 1 and ERK 2. Activation of ERK 1/2 was demonstrated to be independent of NAD(P)H:quinone oxidoreductase using the inhibitor dicoumarol, thus excluding redox cycling as the major mechanism causing these menadione effects. A substantial increase in tyrosine phosphorylation was detected in the cell membrane immunocytochemically upon exposure to menadione, consistent with arylation by menadione bearing the responsibility for the signaling events induced and consistent with the fact that protein tyrosine phosphatases are known targets of arylation reactions. ERK activation was attenuated using specific inhibitors of the epidermal growth factor receptor tyrosine kinase. Similarly, these inhibitors as well as inhibitors of MEK 1/2 counteracted the loss in gap-junctional communication elicited by menadione. This is of interest for chemotherapeutic approaches exploiting the bystander-effect, which is based upon intact GJIC." @default.
• W2113163706 created "2016-06-24" @default.
• W2113163706 creator A5009185911 @default.
• W2113163706 creator A5035738242 @default.
• W2113163706 creator A5042578131 @default.
• W2113163706 creator A5056542379 @default.
• W2113163706 creator A5064301050 @default.
• W2113163706 creator A5065167900 @default.
• W2113163706 creator A5079958902 @default.
• W2113163706 creator A5091525666 @default.
• W2113163706 date "2002-09-01" @default.
• W2113163706 modified "2023-09-23" @default.
• W2113163706 title "2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade." @default.
• W2113163706 cites W1553504149 @default.
• W2113163706 cites W1619161113 @default.
• W2113163706 cites W168276155 @default.
• W2113163706 cites W1966260349 @default.
• W2113163706 cites W1966401658 @default.
• W2113163706 cites W1968617653 @default.
• W2113163706 cites W1977909863 @default.
• W2113163706 cites W1982730855 @default.
• W2113163706 cites W1996272414 @default.
• W2113163706 cites W1997307819 @default.
• W2113163706 cites W2004356154 @default.
• W2113163706 cites W2013878898 @default.
• W2113163706 cites W2016665408 @default.
• W2113163706 cites W2023563217 @default.
• W2113163706 cites W2028754422 @default.
• W2113163706 cites W2051382273 @default.
• W2113163706 cites W2061730206 @default.
• W2113163706 cites W2075497030 @default.
• W2113163706 cites W2080135307 @default.
• W2113163706 cites W2080518716 @default.
• W2113163706 cites W2083605118 @default.
• W2113163706 cites W2086262311 @default.
• W2113163706 cites W2086317499 @default.
• W2113163706 cites W2090990681 @default.
• W2113163706 cites W2095274664 @default.
• W2113163706 cites W2119081695 @default.
• W2113163706 cites W2144933756 @default.
• W2113163706 cites W2160469994 @default.
• W2113163706 cites W2792659630 @default.
• W2113163706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12208742" @default.
• W2113163706 hasPublicationYear "2002" @default.
• W2113163706 type Work @default.
• W2113163706 sameAs 2113163706 @default.
• W2113163706 citedByCount "11" @default.
• W2113163706 countsByYear W21131637062015 @default.
• W2113163706 countsByYear W21131637062018 @default.
• W2113163706 crossrefType "journal-article" @default.
• W2113163706 hasAuthorship W2113163706A5009185911 @default.
• W2113163706 hasAuthorship W2113163706A5035738242 @default.
• W2113163706 hasAuthorship W2113163706A5042578131 @default.
• W2113163706 hasAuthorship W2113163706A5056542379 @default.
• W2113163706 hasAuthorship W2113163706A5064301050 @default.
• W2113163706 hasAuthorship W2113163706A5065167900 @default.
• W2113163706 hasAuthorship W2113163706A5079958902 @default.
• W2113163706 hasAuthorship W2113163706A5091525666 @default.
• W2113163706 hasConcept C11960822 @default.
• W2113163706 hasConcept C153911025 @default.
• W2113163706 hasConcept C170493617 @default.
• W2113163706 hasConcept C181199279 @default.
• W2113163706 hasConcept C184235292 @default.
• W2113163706 hasConcept C185592680 @default.
• W2113163706 hasConcept C2776362946 @default.
• W2113163706 hasConcept C2777553839 @default.
• W2113163706 hasConcept C2777990912 @default.
• W2113163706 hasConcept C2781095387 @default.
• W2113163706 hasConcept C42362537 @default.
• W2113163706 hasConcept C55493867 @default.
• W2113163706 hasConcept C57074206 @default.
• W2113163706 hasConcept C62478195 @default.
• W2113163706 hasConcept C75520062 @default.
• W2113163706 hasConcept C86803240 @default.
• W2113163706 hasConcept C95444343 @default.
• W2113163706 hasConceptScore W2113163706C11960822 @default.
• W2113163706 hasConceptScore W2113163706C153911025 @default.
• W2113163706 hasConceptScore W2113163706C170493617 @default.
• W2113163706 hasConceptScore W2113163706C181199279 @default.
• W2113163706 hasConceptScore W2113163706C184235292 @default.
• W2113163706 hasConceptScore W2113163706C185592680 @default.
• W2113163706 hasConceptScore W2113163706C2776362946 @default.
• W2113163706 hasConceptScore W2113163706C2777553839 @default.
• W2113163706 hasConceptScore W2113163706C2777990912 @default.
• W2113163706 hasConceptScore W2113163706C2781095387 @default.
• W2113163706 hasConceptScore W2113163706C42362537 @default.
• W2113163706 hasConceptScore W2113163706C55493867 @default.
• W2113163706 hasConceptScore W2113163706C57074206 @default.
• W2113163706 hasConceptScore W2113163706C62478195 @default.
• W2113163706 hasConceptScore W2113163706C75520062 @default.
• W2113163706 hasConceptScore W2113163706C86803240 @default.
• W2113163706 hasConceptScore W2113163706C95444343 @default.
• W2113163706 hasIssue "17" @default.
• W2113163706 hasLocation W21131637061 @default.
• W2113163706 hasOpenAccess W2113163706 @default.
• W2113163706 hasPrimaryLocation W21131637061 @default.
• W2113163706 hasRelatedWork W1565481119 @default.
• W2113163706 hasRelatedWork W1994051962 @default.

• next