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• W2113164975 abstract "Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI = 500 ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model." @default.
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• W2113164975 date "2012-01-01" @default.
• W2113164975 modified "2023-09-26" @default.
• W2113164975 title "Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease" @default.
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• W2113164975 doi "https://doi.org/10.1016/j.neulet.2011.10.071" @default.
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