FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113165145> ?p ?o ?g. }

• W2113165145 endingPage "1434" @default.
• W2113165145 startingPage "1425" @default.
• W2113165145 abstract "ABSTRACT The pharmacodynamic profile of clarithromycin (CLR) was evaluated with a murine model of pneumonia. Eight Streptococcus pneumoniae isolates, including three macrolide-sensitive and five macrolide-resistant strains, were inoculated intratracheally into immunocompromised ICR mice as 10 8 -CFU bacterial suspensions. Orally administered CLR daily doses ranging from 5 to 600 mg/kg of body weight were given over 5 days, during which animal survival was monitored. The bacterial density in lung tissues was examined after 24 h of CLR treatment and in control groups. Pharmacokinetic analysis of CLR in mice demonstrated that the regimen of 150 mg/kg twice a day was representative of human pharmacokinetics and was used to compare the efficacy of CLR against sensitive and resistant S. pneumoniae strains. Immunocompetent CBA/J mice were also infected and treated as described above and evaluated for bacterial density and survival to assess the effect of the presence of leukocytes. All three pharmacodynamic parameters, the duration (percent) of the time that serum CLR concentrations remain above the MIC (%T>MIC), the ratio of the area under the concentration-time curve from 0 to 24 h (AUC 0-24 ) to the MIC, and the ratio of the maximum concentration of drug in serum to the MIC, were found to be closely correlated to CLR bacterial efficacy ( P < 0.001). Furthermore, all parameters had close correlation to bacterial density ( r 2 = 0.72 to 0.82), median survival ( r 2 = 0.93 to 0.94), and total percent survival ( r 2 = 0.91 to 0.92). These in vivo data suggest that the bacterial activity of CLR is closely correlated with all three parameters over a wide range of exposures and, as a consequence of parameter interdependency, AUC 0-24 /MIC is the most reasonable predictor of antibiotic efficacy. In this neutropenic pneumonia model, CLR was less efficacious against S. pneumoniae strains for which MICs were ≥4 μg/ml. However, the presence of leukocytes in the immunocompetent mice resulted in improved bactericidal activity, relative to that in the neutropenic animals, despite an MIC of 4 μg/ml." @default.
• W2113165145 created "2016-06-24" @default.
• W2113165145 creator A5026623381 @default.
• W2113165145 creator A5029583788 @default.
• W2113165145 creator A5033406031 @default.
• W2113165145 creator A5051703762 @default.
• W2113165145 creator A5061537073 @default.
• W2113165145 creator A5066849207 @default.
• W2113165145 creator A5069893180 @default.
• W2113165145 creator A5090740872 @default.
• W2113165145 date "2002-05-01" @default.
• W2113165145 modified "2023-09-30" @default.
• W2113165145 title "Pharmacodynamic Assessment of Clarithromycin in a Murine Model of Pneumococcal Pneumonia" @default.
• W2113165145 cites W1960496405 @default.
• W2113165145 cites W1986343942 @default.
• W2113165145 cites W1987566261 @default.
• W2113165145 cites W2033784172 @default.
• W2113165145 cites W2035262283 @default.
• W2113165145 cites W2048754709 @default.
• W2113165145 cites W2091351783 @default.
• W2113165145 cites W2110750635 @default.
• W2113165145 cites W2111376973 @default.
• W2113165145 cites W2118223675 @default.
• W2113165145 cites W2118307170 @default.
• W2113165145 cites W2129531532 @default.
• W2113165145 cites W2138445568 @default.
• W2113165145 cites W2144126572 @default.
• W2113165145 cites W2146539628 @default.
• W2113165145 cites W2153865884 @default.
• W2113165145 cites W2168310137 @default.
• W2113165145 cites W2168840524 @default.
• W2113165145 cites W2171076011 @default.
• W2113165145 cites W3129178518 @default.
• W2113165145 cites W55458275 @default.
• W2113165145 doi "https://doi.org/10.1128/aac.46.5.1425-1434.2002" @default.
• W2113165145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/127127" @default.
• W2113165145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11959578" @default.
• W2113165145 hasPublicationYear "2002" @default.
• W2113165145 type Work @default.
• W2113165145 sameAs 2113165145 @default.
• W2113165145 citedByCount "70" @default.
• W2113165145 countsByYear W21131651452012 @default.
• W2113165145 countsByYear W21131651452013 @default.
• W2113165145 countsByYear W21131651452015 @default.
• W2113165145 countsByYear W21131651452016 @default.
• W2113165145 countsByYear W21131651452017 @default.
• W2113165145 countsByYear W21131651452018 @default.
• W2113165145 countsByYear W21131651452019 @default.
• W2113165145 countsByYear W21131651452020 @default.
• W2113165145 countsByYear W21131651452021 @default.
• W2113165145 countsByYear W21131651452023 @default.
• W2113165145 crossrefType "journal-article" @default.
• W2113165145 hasAuthorship W2113165145A5026623381 @default.
• W2113165145 hasAuthorship W2113165145A5029583788 @default.
• W2113165145 hasAuthorship W2113165145A5033406031 @default.
• W2113165145 hasAuthorship W2113165145A5051703762 @default.
• W2113165145 hasAuthorship W2113165145A5061537073 @default.
• W2113165145 hasAuthorship W2113165145A5066849207 @default.
• W2113165145 hasAuthorship W2113165145A5069893180 @default.
• W2113165145 hasAuthorship W2113165145A5090740872 @default.
• W2113165145 hasBestOaLocation W21131651452 @default.
• W2113165145 hasConcept C111113717 @default.
• W2113165145 hasConcept C112705442 @default.
• W2113165145 hasConcept C126322002 @default.
• W2113165145 hasConcept C176947019 @default.
• W2113165145 hasConcept C2776345407 @default.
• W2113165145 hasConcept C2776962512 @default.
• W2113165145 hasConcept C2777914695 @default.
• W2113165145 hasConcept C2778276568 @default.
• W2113165145 hasConcept C2779892413 @default.
• W2113165145 hasConcept C2781253189 @default.
• W2113165145 hasConcept C2781413609 @default.
• W2113165145 hasConcept C3019249092 @default.
• W2113165145 hasConcept C501593827 @default.
• W2113165145 hasConcept C523546767 @default.
• W2113165145 hasConcept C54355233 @default.
• W2113165145 hasConcept C71924100 @default.
• W2113165145 hasConcept C86803240 @default.
• W2113165145 hasConcept C89423630 @default.
• W2113165145 hasConcept C98274493 @default.
• W2113165145 hasConceptScore W2113165145C111113717 @default.
• W2113165145 hasConceptScore W2113165145C112705442 @default.
• W2113165145 hasConceptScore W2113165145C126322002 @default.
• W2113165145 hasConceptScore W2113165145C176947019 @default.
• W2113165145 hasConceptScore W2113165145C2776345407 @default.
• W2113165145 hasConceptScore W2113165145C2776962512 @default.
• W2113165145 hasConceptScore W2113165145C2777914695 @default.
• W2113165145 hasConceptScore W2113165145C2778276568 @default.
• W2113165145 hasConceptScore W2113165145C2779892413 @default.
• W2113165145 hasConceptScore W2113165145C2781253189 @default.
• W2113165145 hasConceptScore W2113165145C2781413609 @default.
• W2113165145 hasConceptScore W2113165145C3019249092 @default.
• W2113165145 hasConceptScore W2113165145C501593827 @default.
• W2113165145 hasConceptScore W2113165145C523546767 @default.
• W2113165145 hasConceptScore W2113165145C54355233 @default.
• W2113165145 hasConceptScore W2113165145C71924100 @default.
• W2113165145 hasConceptScore W2113165145C86803240 @default.
• W2113165145 hasConceptScore W2113165145C89423630 @default.

• next