Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113165796> ?p ?o ?g. }
- W2113165796 endingPage "4647" @default.
- W2113165796 startingPage "4641" @default.
- W2113165796 abstract "Abstract Monosomy 7 (−7) and deletion 7q del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and −7 or del(7q) with or without other cytogenetic aberrations ± other]. Karyotypes included −7 (n = 90), −7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with −7 ± other compared with del(7q) ± other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) ± other compared with −7 ± other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with −7 and inv(3),−5/del(5q), or + 21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification." @default.
- W2113165796 created "2016-06-24" @default.
- W2113165796 creator A5003366137 @default.
- W2113165796 creator A5004202875 @default.
- W2113165796 creator A5007262193 @default.
- W2113165796 creator A5007738420 @default.
- W2113165796 creator A5008517987 @default.
- W2113165796 creator A5012776569 @default.
- W2113165796 creator A5017647313 @default.
- W2113165796 creator A5021059238 @default.
- W2113165796 creator A5022712318 @default.
- W2113165796 creator A5027364145 @default.
- W2113165796 creator A5032384303 @default.
- W2113165796 creator A5035945818 @default.
- W2113165796 creator A5036667713 @default.
- W2113165796 creator A5036837883 @default.
- W2113165796 creator A5037374709 @default.
- W2113165796 creator A5043037950 @default.
- W2113165796 creator A5046857875 @default.
- W2113165796 creator A5051123172 @default.
- W2113165796 creator A5053271583 @default.
- W2113165796 creator A5062366315 @default.
- W2113165796 creator A5066861312 @default.
- W2113165796 creator A5073788325 @default.
- W2113165796 creator A5075049442 @default.
- W2113165796 creator A5075968682 @default.
- W2113165796 creator A5076457958 @default.
- W2113165796 creator A5076502958 @default.
- W2113165796 creator A5079852624 @default.
- W2113165796 creator A5082401017 @default.
- W2113165796 creator A5084785590 @default.
- W2113165796 creator A5088303415 @default.
- W2113165796 creator A5090678844 @default.
- W2113165796 date "2007-06-01" @default.
- W2113165796 modified "2023-10-01" @default.
- W2113165796 title "Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study" @default.
- W2113165796 cites W138215329 @default.
- W2113165796 cites W1534965621 @default.
- W2113165796 cites W170068962 @default.
- W2113165796 cites W1702313568 @default.
- W2113165796 cites W1935926025 @default.
- W2113165796 cites W1972978214 @default.
- W2113165796 cites W2001979268 @default.
- W2113165796 cites W2013900672 @default.
- W2113165796 cites W2017666957 @default.
- W2113165796 cites W2018895375 @default.
- W2113165796 cites W2018925795 @default.
- W2113165796 cites W2026330020 @default.
- W2113165796 cites W2039757121 @default.
- W2113165796 cites W2041282815 @default.
- W2113165796 cites W2045825346 @default.
- W2113165796 cites W2051683956 @default.
- W2113165796 cites W2060201878 @default.
- W2113165796 cites W2061549613 @default.
- W2113165796 cites W2074681027 @default.
- W2113165796 cites W2078025015 @default.
- W2113165796 cites W2087644365 @default.
- W2113165796 cites W2097198718 @default.
- W2113165796 cites W2102189087 @default.
- W2113165796 cites W2106194243 @default.
- W2113165796 cites W2116464033 @default.
- W2113165796 cites W2139813696 @default.
- W2113165796 cites W2140196635 @default.
- W2113165796 cites W2148774731 @default.
- W2113165796 cites W2151848256 @default.
- W2113165796 cites W2155891710 @default.
- W2113165796 cites W2177773249 @default.
- W2113165796 cites W228303033 @default.
- W2113165796 cites W4293241248 @default.
- W2113165796 cites W4474461 @default.
- W2113165796 cites W97477215 @default.
- W2113165796 doi "https://doi.org/10.1182/blood-2006-10-051342" @default.
- W2113165796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17299091" @default.
- W2113165796 hasPublicationYear "2007" @default.
- W2113165796 type Work @default.
- W2113165796 sameAs 2113165796 @default.
- W2113165796 citedByCount "126" @default.
- W2113165796 countsByYear W21131657962012 @default.
- W2113165796 countsByYear W21131657962013 @default.
- W2113165796 countsByYear W21131657962014 @default.
- W2113165796 countsByYear W21131657962015 @default.
- W2113165796 countsByYear W21131657962016 @default.
- W2113165796 countsByYear W21131657962017 @default.
- W2113165796 countsByYear W21131657962018 @default.
- W2113165796 countsByYear W21131657962019 @default.
- W2113165796 countsByYear W21131657962020 @default.
- W2113165796 countsByYear W21131657962021 @default.
- W2113165796 countsByYear W21131657962022 @default.
- W2113165796 countsByYear W21131657962023 @default.
- W2113165796 crossrefType "journal-article" @default.
- W2113165796 hasAuthorship W2113165796A5003366137 @default.
- W2113165796 hasAuthorship W2113165796A5004202875 @default.
- W2113165796 hasAuthorship W2113165796A5007262193 @default.
- W2113165796 hasAuthorship W2113165796A5007738420 @default.
- W2113165796 hasAuthorship W2113165796A5008517987 @default.
- W2113165796 hasAuthorship W2113165796A5012776569 @default.
- W2113165796 hasAuthorship W2113165796A5017647313 @default.
- W2113165796 hasAuthorship W2113165796A5021059238 @default.