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• W2113166182 abstract "Asthma is a complex disease that is caused by genetic and environmental factors. The production of interleukin (IL)-4, which can influence mast cell responsiveness to immunoglobulin (Ig) E--mediated signaling, could be modified by genetic variants in the IL-4 promoter.To investigate the association between the IL-4 and IL-4RA promoter polymorphisms and asthma in a sample of Iranian patients.We used polymerase chain reaction with sequence-specific primers to investigate the allele and genotype frequencies of 2 polymorphic genes coding for IL-4 and IL-4RA in 59 Iranian patients with asthma and 139 healthy controls.The most frequent genotypes in the patient group were IL-4TC (-590), IL-4TC (-33), IL-4 GT (-1098), and IL-4RA GA (+1902). In contrast, the frequencies of IL-4 CC (-590), IL-4 CC (-33), IL-4TT (-1098), and IL-4RAAA (+1902) were significantly lower in the patient group than in the control group. The most frequent haplotypes in our patients were IL-4 TCT and GTC at positions -1098,-590,-33. The mean total serum IgE level in patients with the TTT/GCC genotype was 258.8 IU/mL, which was significantly higher than the 95.4 IU/mL observed for other genotypes.We showed a strong association between the polymorphisms of the IL-4 gene promoter at positions -590, -33 and -1098 and bronchial asthma. We also demonstrated an association between their haplotypes and serum total IgE." @default.
• W2113166182 created "2016-06-24" @default.
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• W2113166182 date "2009-01-01" @default.
• W2113166182 modified "2023-09-24" @default.
• W2113166182 title "Polymorphisms in IL4 and iLARA confer susceptibility to asthma." @default.
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• W2113166182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20128416" @default.
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