Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113166532> ?p ?o ?g. }
- W2113166532 endingPage "464" @default.
- W2113166532 startingPage "453" @default.
- W2113166532 abstract "In this study, I examined whether sperm hyperactivation in hamster is regulated by steroid hormones such as estrogen (estradiol, E(2)) and progesterone. Although sperm hyperactivation was enhanced by progesterone, 17beta-estradiol (17betaE(2)) itself did not affect sperm hyperactivation. However, 17betaE(2) suppressed progesterone-enhanced hyperactivation in a concentration-dependent manner through non-genomic pathways when spermatozoa were exposed to 17betaE(2) at the same time or before exposure to progesterone. When spermatozoa were exposed to 17betaE(2) after exposure to progesterone, 17betaE(2) did not suppress progesterone-enhanced hyperactivation. Moreover, 17alpha-estradiol, an inactive isomer of E(2), did not suppress progesterone-enhanced hyperactivation. Observations using a FITC-conjugated 17betaE(2) showed that it binds to the acrosome region of the sperm head. Binding of 17betaE(2) to spermatozoa was not inhibited by progesterone, although 17betaE(2) did not suppress progesterone-enhanced hyperactivation when spermatozoa were exposed to 17betaE(2) after exposure to progesterone. On the other hand, binding of progesterone to spermatozoa was also not inhibited by 17betaE(2) even if progesterone-enhanced hyperactivation was suppressed by 17betaE(2). Although tyrosine phosphorylations of sperm proteins were enhanced by progesterone, enhancement of tyrosine phosphorylations by progesterone was suppressed by 17betaE(2). Moreover, tyrosine phosphorylations were inhibited by 17betaE(2) when only 17betaE(2) was added to the medium. From these results, it is likely that 17betaE(2) competitively suppresses progesterone-enhanced hyperactivation through the inhibition of tyrosine phosphorylations via non-genomic pathways." @default.
- W2113166532 created "2016-06-24" @default.
- W2113166532 creator A5057514407 @default.
- W2113166532 date "2010-09-01" @default.
- W2113166532 modified "2023-10-13" @default.
- W2113166532 title "Suppression of progesterone-enhanced hyperactivation in hamster spermatozoa by estrogen" @default.
- W2113166532 cites W1570735806 @default.
- W2113166532 cites W1922120593 @default.
- W2113166532 cites W1974064016 @default.
- W2113166532 cites W1976872356 @default.
- W2113166532 cites W1988010283 @default.
- W2113166532 cites W1989159221 @default.
- W2113166532 cites W1990762193 @default.
- W2113166532 cites W1996703972 @default.
- W2113166532 cites W1998071991 @default.
- W2113166532 cites W2013991049 @default.
- W2113166532 cites W2023322314 @default.
- W2113166532 cites W2028102639 @default.
- W2113166532 cites W2029032935 @default.
- W2113166532 cites W2037494992 @default.
- W2113166532 cites W2037601841 @default.
- W2113166532 cites W2064069319 @default.
- W2113166532 cites W2074910744 @default.
- W2113166532 cites W2079154892 @default.
- W2113166532 cites W2081058055 @default.
- W2113166532 cites W2084163192 @default.
- W2113166532 cites W2090856555 @default.
- W2113166532 cites W2098931374 @default.
- W2113166532 cites W2100837269 @default.
- W2113166532 cites W2133265118 @default.
- W2113166532 cites W2134797808 @default.
- W2113166532 cites W2140439130 @default.
- W2113166532 cites W2152324796 @default.
- W2113166532 cites W2157744295 @default.
- W2113166532 cites W2158418709 @default.
- W2113166532 cites W2166856535 @default.
- W2113166532 cites W2372928330 @default.
- W2113166532 cites W2399801885 @default.
- W2113166532 cites W4235184415 @default.
- W2113166532 cites W4238550077 @default.
- W2113166532 doi "https://doi.org/10.1530/rep-10-0168" @default.
- W2113166532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20562298" @default.
- W2113166532 hasPublicationYear "2010" @default.
- W2113166532 type Work @default.
- W2113166532 sameAs 2113166532 @default.
- W2113166532 citedByCount "28" @default.
- W2113166532 countsByYear W21131665322012 @default.
- W2113166532 countsByYear W21131665322013 @default.
- W2113166532 countsByYear W21131665322014 @default.
- W2113166532 countsByYear W21131665322015 @default.
- W2113166532 countsByYear W21131665322016 @default.
- W2113166532 countsByYear W21131665322017 @default.
- W2113166532 countsByYear W21131665322018 @default.
- W2113166532 countsByYear W21131665322019 @default.
- W2113166532 countsByYear W21131665322020 @default.
- W2113166532 countsByYear W21131665322021 @default.
- W2113166532 countsByYear W21131665322022 @default.
- W2113166532 countsByYear W21131665322023 @default.
- W2113166532 crossrefType "journal-article" @default.
- W2113166532 hasAuthorship W2113166532A5057514407 @default.
- W2113166532 hasBestOaLocation W21131665321 @default.
- W2113166532 hasConcept C126322002 @default.
- W2113166532 hasConcept C134018914 @default.
- W2113166532 hasConcept C16685009 @default.
- W2113166532 hasConcept C185592680 @default.
- W2113166532 hasConcept C2776165026 @default.
- W2113166532 hasConcept C2777164284 @default.
- W2113166532 hasConcept C2778366672 @default.
- W2113166532 hasConcept C2778575167 @default.
- W2113166532 hasConcept C2781087480 @default.
- W2113166532 hasConcept C55493867 @default.
- W2113166532 hasConcept C71924100 @default.
- W2113166532 hasConcept C86803240 @default.
- W2113166532 hasConceptScore W2113166532C126322002 @default.
- W2113166532 hasConceptScore W2113166532C134018914 @default.
- W2113166532 hasConceptScore W2113166532C16685009 @default.
- W2113166532 hasConceptScore W2113166532C185592680 @default.
- W2113166532 hasConceptScore W2113166532C2776165026 @default.
- W2113166532 hasConceptScore W2113166532C2777164284 @default.
- W2113166532 hasConceptScore W2113166532C2778366672 @default.
- W2113166532 hasConceptScore W2113166532C2778575167 @default.
- W2113166532 hasConceptScore W2113166532C2781087480 @default.
- W2113166532 hasConceptScore W2113166532C55493867 @default.
- W2113166532 hasConceptScore W2113166532C71924100 @default.
- W2113166532 hasConceptScore W2113166532C86803240 @default.
- W2113166532 hasIssue "3" @default.
- W2113166532 hasLocation W21131665321 @default.
- W2113166532 hasLocation W21131665322 @default.
- W2113166532 hasOpenAccess W2113166532 @default.
- W2113166532 hasPrimaryLocation W21131665321 @default.
- W2113166532 hasRelatedWork W1539666633 @default.
- W2113166532 hasRelatedWork W2061225056 @default.
- W2113166532 hasRelatedWork W2063360877 @default.
- W2113166532 hasRelatedWork W2085202127 @default.
- W2113166532 hasRelatedWork W2150205541 @default.
- W2113166532 hasRelatedWork W2157969912 @default.
- W2113166532 hasRelatedWork W2549919366 @default.
- W2113166532 hasRelatedWork W265917890 @default.