FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113172016> ?p ?o ?g. }

• W2113172016 endingPage "2519" @default.
• W2113172016 startingPage "2510" @default.
• W2113172016 abstract "Aberrant expression of the T-box transcription factor brachyury in human carcinomas drives the phenomenon of epithelial-mesenchymal transition (EMT), a phenotypic modulation that facilitates tumor dissemination and resistance to conventional therapies, including chemotherapy and radiotherapy. By generating isogenic cancer cell lines with various levels of brachyury expression, we demonstrate that high levels of brachyury also significantly reduce the susceptibility of cancer cells to lysis by both antigen-specific T cells and natural killer cells. Our results indicated that resistance of brachyury-high tumor cells to immune-mediated attack was due to inefficient caspase-dependent apoptosis, manifested as inefficient nuclear lamin degradation in the presence of activated effector caspases. We correlated this phenomenon with loss of cell-cycle-dependent kinase 1 (CDK1), which mediates lamin phosphorylation. In support of a causal connection, pretreatment of tumor cells with a specific inhibitor of WEE1, a negative regulator kinase of CDK1, could counter the defective apoptosis of tumor cells expressing high levels of brachyury. Thus, our findings suggested that reconstituting CDK1 activity to threshold levels may be sufficient to restore immunosurveillance of mesenchymal-like cancer cells that have escaped previous immune detection or eradication." @default.
• W2113172016 created "2016-06-24" @default.
• W2113172016 creator A5018956979 @default.
• W2113172016 creator A5022840249 @default.
• W2113172016 creator A5025862962 @default.
• W2113172016 creator A5070191245 @default.
• W2113172016 creator A5081826448 @default.
• W2113172016 date "2014-04-30" @default.
• W2113172016 modified "2023-10-02" @default.
• W2113172016 title "WEE1 Inhibition Alleviates Resistance to Immune Attack of Tumor Cells Undergoing Epithelial–Mesenchymal Transition" @default.
• W2113172016 cites W1536311055 @default.
• W2113172016 cites W1951919070 @default.
• W2113172016 cites W1993640545 @default.
• W2113172016 cites W2006987944 @default.
• W2113172016 cites W2038143768 @default.
• W2113172016 cites W2043979562 @default.
• W2113172016 cites W2049491375 @default.
• W2113172016 cites W2054129665 @default.
• W2113172016 cites W2055498399 @default.
• W2113172016 cites W2063192133 @default.
• W2113172016 cites W2065634301 @default.
• W2113172016 cites W2070156993 @default.
• W2113172016 cites W2072245143 @default.
• W2113172016 cites W2074678011 @default.
• W2113172016 cites W2076575466 @default.
• W2113172016 cites W2094848889 @default.
• W2113172016 cites W2099439420 @default.
• W2113172016 cites W2102124205 @default.
• W2113172016 cites W2103514020 @default.
• W2113172016 cites W2104079620 @default.
• W2113172016 cites W2109998353 @default.
• W2113172016 cites W2110024452 @default.
• W2113172016 cites W2112680319 @default.
• W2113172016 cites W2114154136 @default.
• W2113172016 cites W2117692326 @default.
• W2113172016 cites W2120656656 @default.
• W2113172016 cites W2142300779 @default.
• W2113172016 cites W2142325694 @default.
• W2113172016 cites W2153935963 @default.
• W2113172016 cites W2154589460 @default.
• W2113172016 cites W2155892126 @default.
• W2113172016 cites W2157005857 @default.
• W2113172016 cites W2167479335 @default.
• W2113172016 cites W2168747781 @default.
• W2113172016 cites W2172044251 @default.
• W2113172016 cites W2340807121 @default.
• W2113172016 cites W4234181567 @default.
• W2113172016 doi "https://doi.org/10.1158/0008-5472.can-13-1894" @default.
• W2113172016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4011139" @default.
• W2113172016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24626094" @default.
• W2113172016 hasPublicationYear "2014" @default.
• W2113172016 type Work @default.
• W2113172016 sameAs 2113172016 @default.
• W2113172016 citedByCount "67" @default.
• W2113172016 countsByYear W21131720162014 @default.
• W2113172016 countsByYear W21131720162015 @default.
• W2113172016 countsByYear W21131720162016 @default.
• W2113172016 countsByYear W21131720162017 @default.
• W2113172016 countsByYear W21131720162018 @default.
• W2113172016 countsByYear W21131720162019 @default.
• W2113172016 countsByYear W21131720162020 @default.
• W2113172016 countsByYear W21131720162021 @default.
• W2113172016 countsByYear W21131720162022 @default.
• W2113172016 countsByYear W21131720162023 @default.
• W2113172016 crossrefType "journal-article" @default.
• W2113172016 hasAuthorship W2113172016A5018956979 @default.
• W2113172016 hasAuthorship W2113172016A5022840249 @default.
• W2113172016 hasAuthorship W2113172016A5025862962 @default.
• W2113172016 hasAuthorship W2113172016A5070191245 @default.
• W2113172016 hasAuthorship W2113172016A5081826448 @default.
• W2113172016 hasBestOaLocation W21131720161 @default.
• W2113172016 hasConcept C104317684 @default.
• W2113172016 hasConcept C120504264 @default.
• W2113172016 hasConcept C121608353 @default.
• W2113172016 hasConcept C145103041 @default.
• W2113172016 hasConcept C190283241 @default.
• W2113172016 hasConcept C2779013556 @default.
• W2113172016 hasConcept C2780915607 @default.
• W2113172016 hasConcept C29537977 @default.
• W2113172016 hasConcept C46122727 @default.
• W2113172016 hasConcept C502942594 @default.
• W2113172016 hasConcept C54355233 @default.
• W2113172016 hasConcept C55493867 @default.
• W2113172016 hasConcept C76419328 @default.
• W2113172016 hasConcept C86803240 @default.
• W2113172016 hasConcept C95444343 @default.
• W2113172016 hasConcept C96232424 @default.
• W2113172016 hasConceptScore W2113172016C104317684 @default.
• W2113172016 hasConceptScore W2113172016C120504264 @default.
• W2113172016 hasConceptScore W2113172016C121608353 @default.
• W2113172016 hasConceptScore W2113172016C145103041 @default.
• W2113172016 hasConceptScore W2113172016C190283241 @default.
• W2113172016 hasConceptScore W2113172016C2779013556 @default.
• W2113172016 hasConceptScore W2113172016C2780915607 @default.
• W2113172016 hasConceptScore W2113172016C29537977 @default.
• W2113172016 hasConceptScore W2113172016C46122727 @default.
• W2113172016 hasConceptScore W2113172016C502942594 @default.
• W2113172016 hasConceptScore W2113172016C54355233 @default.

• next