Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113177406> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2113177406 abstract "Objectives: Gross residual disease (RD) following primary cytoreduction is the best predictor of overall survival in patients with high-grade serous ovarian cancer (HGSOC). Accurate identification of patients who will have RD has been elusive, prompting many to undergo unnecessary surgical exploration. Our goal was to identify and validate molecular markers associated with high rates of RD. Methods: We interrogated two publicly available genomic datasets of primary HGSOC for genes consistently differentially expressed in RD and no residual disease (R0) cohorts and significant at a false-discovery rate (FDR) of 10%. Genomic expression was further validated in an independent cohort (chemonaive ovarian tumor tissues) using quantitative reverse-transcriptase polymerase chain reaction followed by a blinded prediction of RD. A one-sided Fisher’s exact test was used to compare RD rates in predicted highand low-risk groups. Results: In the TCGA and Tothill datasets, 491 and 189 patients, respectively, met the criteria for inclusion. As expected, survival was significantly better for patients with R0 resection compared to those with any RD. We identified 47 probesets, representing 38 different genes, significant in both datasets at 10% FDR. These included probesets for FABP4 and ADH1B, which tracked tightly and showed dynamic ranges N16-fold. For these genes, there is a level of expression above which nearly all patients have RD; the distribution of expression values is roughly bimodal. In the validation cohort, using the top quartile of FABP4 polymerase chain reaction values as a prespecified cutoff, we found 30/35 RD cases in the high-expression group and 54/104 in the low-expression group (P= 0.0002). Our predictive method based on FABP4, therefore, correctly identified a cohort of patients with significantly increased rates of RD in an independent test set. Further examination of the ADH1B results showed that predictions using either ADH1B alone or in combination with FABP4 would have produced similar results. Examining the reasons for RD in the high-risk cohort suggests a preponderance of cases with either innumerable sites of disease or unresectable disease involving vital regions. Conclusions: High FABP4 and ADH1B expression are associated with significantly higher risk of RD in HGSOC patients. Patients with high tumoral FABP4 levels may be candidates for neoadjuvant chemotherapy." @default.
- W2113177406 created "2016-06-24" @default.
- W2113177406 creator A5008801459 @default.
- W2113177406 creator A5009234043 @default.
- W2113177406 creator A5009442045 @default.
- W2113177406 creator A5016393418 @default.
- W2113177406 creator A5038095941 @default.
- W2113177406 creator A5048829568 @default.
- W2113177406 creator A5054033791 @default.
- W2113177406 creator A5066564517 @default.
- W2113177406 creator A5080528785 @default.
- W2113177406 creator A5085700191 @default.
- W2113177406 date "2014-06-01" @default.
- W2113177406 modified "2023-10-02" @default.
- W2113177406 title "Molecular predictors of residual disease in patients with ovarian cancer" @default.
- W2113177406 doi "https://doi.org/10.1016/j.ygyno.2014.03.081" @default.
- W2113177406 hasPublicationYear "2014" @default.
- W2113177406 type Work @default.
- W2113177406 sameAs 2113177406 @default.
- W2113177406 citedByCount "0" @default.
- W2113177406 crossrefType "journal-article" @default.
- W2113177406 hasAuthorship W2113177406A5008801459 @default.
- W2113177406 hasAuthorship W2113177406A5009234043 @default.
- W2113177406 hasAuthorship W2113177406A5009442045 @default.
- W2113177406 hasAuthorship W2113177406A5016393418 @default.
- W2113177406 hasAuthorship W2113177406A5038095941 @default.
- W2113177406 hasAuthorship W2113177406A5048829568 @default.
- W2113177406 hasAuthorship W2113177406A5054033791 @default.
- W2113177406 hasAuthorship W2113177406A5066564517 @default.
- W2113177406 hasAuthorship W2113177406A5080528785 @default.
- W2113177406 hasAuthorship W2113177406A5085700191 @default.
- W2113177406 hasConcept C104317684 @default.
- W2113177406 hasConcept C121608353 @default.
- W2113177406 hasConcept C126322002 @default.
- W2113177406 hasConcept C142724271 @default.
- W2113177406 hasConcept C143998085 @default.
- W2113177406 hasConcept C150173356 @default.
- W2113177406 hasConcept C193244246 @default.
- W2113177406 hasConcept C2779134260 @default.
- W2113177406 hasConcept C2780427987 @default.
- W2113177406 hasConcept C44249647 @default.
- W2113177406 hasConcept C49105822 @default.
- W2113177406 hasConcept C54355233 @default.
- W2113177406 hasConcept C68443243 @default.
- W2113177406 hasConcept C71924100 @default.
- W2113177406 hasConcept C72563966 @default.
- W2113177406 hasConcept C86803240 @default.
- W2113177406 hasConceptScore W2113177406C104317684 @default.
- W2113177406 hasConceptScore W2113177406C121608353 @default.
- W2113177406 hasConceptScore W2113177406C126322002 @default.
- W2113177406 hasConceptScore W2113177406C142724271 @default.
- W2113177406 hasConceptScore W2113177406C143998085 @default.
- W2113177406 hasConceptScore W2113177406C150173356 @default.
- W2113177406 hasConceptScore W2113177406C193244246 @default.
- W2113177406 hasConceptScore W2113177406C2779134260 @default.
- W2113177406 hasConceptScore W2113177406C2780427987 @default.
- W2113177406 hasConceptScore W2113177406C44249647 @default.
- W2113177406 hasConceptScore W2113177406C49105822 @default.
- W2113177406 hasConceptScore W2113177406C54355233 @default.
- W2113177406 hasConceptScore W2113177406C68443243 @default.
- W2113177406 hasConceptScore W2113177406C71924100 @default.
- W2113177406 hasConceptScore W2113177406C72563966 @default.
- W2113177406 hasConceptScore W2113177406C86803240 @default.
- W2113177406 hasLocation W21131774061 @default.
- W2113177406 hasOpenAccess W2113177406 @default.
- W2113177406 hasPrimaryLocation W21131774061 @default.
- W2113177406 hasRelatedWork W1493845281 @default.
- W2113177406 hasRelatedWork W1981379144 @default.
- W2113177406 hasRelatedWork W1988692919 @default.
- W2113177406 hasRelatedWork W2000771269 @default.
- W2113177406 hasRelatedWork W2030847230 @default.
- W2113177406 hasRelatedWork W2114509775 @default.
- W2113177406 hasRelatedWork W2167963368 @default.
- W2113177406 hasRelatedWork W2309047380 @default.
- W2113177406 hasRelatedWork W2317044271 @default.
- W2113177406 hasRelatedWork W2326398359 @default.
- W2113177406 hasRelatedWork W2407118725 @default.
- W2113177406 hasRelatedWork W2534823704 @default.
- W2113177406 hasRelatedWork W2569908248 @default.
- W2113177406 hasRelatedWork W2612849471 @default.
- W2113177406 hasRelatedWork W2774162881 @default.
- W2113177406 hasRelatedWork W2887479062 @default.
- W2113177406 hasRelatedWork W2980939722 @default.
- W2113177406 hasRelatedWork W2982515585 @default.
- W2113177406 hasRelatedWork W3102984263 @default.
- W2113177406 hasRelatedWork W3199992871 @default.
- W2113177406 isParatext "false" @default.
- W2113177406 isRetracted "false" @default.
- W2113177406 magId "2113177406" @default.
- W2113177406 workType "article" @default.