Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113178587> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2113178587 endingPage "S194" @default.
- W2113178587 startingPage "S194" @default.
- W2113178587 abstract "Febuxostat, a non-purine xanthine oxidase inhibitor, has been reported to have a stronger effect and more safety on hyperuricemia than allopurinol. However, there is not available on the effect of febuxostat in hypertensive patients with chronic heart failure (CHF) and chronic kidney disease (CKD). (Methods) The aim of this study is to examine the efficacy and safety of febuxostat in hypertensive patients with CHF and CKD for treating hyperuricemia. Twenty hyperuricemic patients with hypertension(HT), CHF and CKD were enrolled and treated with febuxostat(10-20mg/day). Serum uric acid concentrations and serum estimated GFR levels in the 3 months before and after the start of febuxostat treatment were collected for HT, CHF and CKD patients switched from allopurinol after failing to achieve serum uric acid concentrations <6.0mg/dl. Evaluable data were available for 20 patients, 20% of whom had advanced CKD (eGFR<30ml/min/1.73m2). Mean dose of febuxostat was 11 (±3.7)mg/day. By using febuxostat, mean serum uric acid concentration decreased from 7.6 (±1.2) mg/dl at baseline to 6.2 (±0.9)&mg/dL at 3 months(p<0.001) 35% of patients achieved a level <6.0mg/dL. No serious adverse reactions were noted with febuxostat, and there were no significant changes in blood pressure, heart rate, total cholesterol, triglyceride, hemoglobin A1c, and hepatic and renal function. Febuxostat was effective for hyperuricemia in patients with HT, CHF and CKD without severe side effects." @default.
- W2113178587 created "2016-06-24" @default.
- W2113178587 creator A5020771892 @default.
- W2113178587 creator A5025153902 @default.
- W2113178587 creator A5046119742 @default.
- W2113178587 date "2014-10-01" @default.
- W2113178587 modified "2023-10-02" @default.
- W2113178587 title "The Efficacy and Safety of Febuxostat for Hyperuricemia in Hypertensive Patients with Chronic Heart Failure and Chronic Kidney Disease" @default.
- W2113178587 doi "https://doi.org/10.1016/j.cardfail.2014.07.345" @default.
- W2113178587 hasPublicationYear "2014" @default.
- W2113178587 type Work @default.
- W2113178587 sameAs 2113178587 @default.
- W2113178587 citedByCount "0" @default.
- W2113178587 crossrefType "journal-article" @default.
- W2113178587 hasAuthorship W2113178587A5020771892 @default.
- W2113178587 hasAuthorship W2113178587A5025153902 @default.
- W2113178587 hasAuthorship W2113178587A5046119742 @default.
- W2113178587 hasBestOaLocation W21131785871 @default.
- W2113178587 hasConcept C126322002 @default.
- W2113178587 hasConcept C126894567 @default.
- W2113178587 hasConcept C159641895 @default.
- W2113178587 hasConcept C164705383 @default.
- W2113178587 hasConcept C181199279 @default.
- W2113178587 hasConcept C185592680 @default.
- W2113178587 hasConcept C2777820942 @default.
- W2113178587 hasConcept C2778102346 @default.
- W2113178587 hasConcept C2778198053 @default.
- W2113178587 hasConcept C2778653478 @default.
- W2113178587 hasConcept C2779721657 @default.
- W2113178587 hasConcept C2779881121 @default.
- W2113178587 hasConcept C2780261098 @default.
- W2113178587 hasConcept C2780402116 @default.
- W2113178587 hasConcept C2780932893 @default.
- W2113178587 hasConcept C55493867 @default.
- W2113178587 hasConcept C71924100 @default.
- W2113178587 hasConcept C90924648 @default.
- W2113178587 hasConceptScore W2113178587C126322002 @default.
- W2113178587 hasConceptScore W2113178587C126894567 @default.
- W2113178587 hasConceptScore W2113178587C159641895 @default.
- W2113178587 hasConceptScore W2113178587C164705383 @default.
- W2113178587 hasConceptScore W2113178587C181199279 @default.
- W2113178587 hasConceptScore W2113178587C185592680 @default.
- W2113178587 hasConceptScore W2113178587C2777820942 @default.
- W2113178587 hasConceptScore W2113178587C2778102346 @default.
- W2113178587 hasConceptScore W2113178587C2778198053 @default.
- W2113178587 hasConceptScore W2113178587C2778653478 @default.
- W2113178587 hasConceptScore W2113178587C2779721657 @default.
- W2113178587 hasConceptScore W2113178587C2779881121 @default.
- W2113178587 hasConceptScore W2113178587C2780261098 @default.
- W2113178587 hasConceptScore W2113178587C2780402116 @default.
- W2113178587 hasConceptScore W2113178587C2780932893 @default.
- W2113178587 hasConceptScore W2113178587C55493867 @default.
- W2113178587 hasConceptScore W2113178587C71924100 @default.
- W2113178587 hasConceptScore W2113178587C90924648 @default.
- W2113178587 hasIssue "10" @default.
- W2113178587 hasLocation W21131785871 @default.
- W2113178587 hasOpenAccess W2113178587 @default.
- W2113178587 hasPrimaryLocation W21131785871 @default.
- W2113178587 hasRelatedWork W192509142 @default.
- W2113178587 hasRelatedWork W1966731608 @default.
- W2113178587 hasRelatedWork W2016825263 @default.
- W2113178587 hasRelatedWork W2171230117 @default.
- W2113178587 hasRelatedWork W2185490382 @default.
- W2113178587 hasRelatedWork W2394470303 @default.
- W2113178587 hasRelatedWork W2423434425 @default.
- W2113178587 hasRelatedWork W2538925267 @default.
- W2113178587 hasRelatedWork W3041980498 @default.
- W2113178587 hasRelatedWork W3116844873 @default.
- W2113178587 hasVolume "20" @default.
- W2113178587 isParatext "false" @default.
- W2113178587 isRetracted "false" @default.
- W2113178587 magId "2113178587" @default.
- W2113178587 workType "article" @default.