Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113179285> ?p ?o ?g. }
- W2113179285 endingPage "217" @default.
- W2113179285 startingPage "209" @default.
- W2113179285 abstract "Abstract Objective To design a new class of selective neuronal nitric oxide synthase (NOS) inhibitors, and demonstrate that administration in a rabbit model for cerebral palsy (CP) prevents hypoxia‐ischemia–induced deaths and reduces the number of newborn kits exhibiting signs of CP. Methods We used a novel computer‐based drug design method called fragment hopping to identify new chemical entities, synthesized them, and conducted in vitro enzyme inhibition studies with the three isozymes of NOS and in vivo experiments to monitor cardiovascular effects on pregnant rabbit dams, NOS activity, and NO x (NO and NO 2 ) concentration in fetal brain, and assess neurobehavioral effects on kits born to saline‐ and compound treated dams. Results The computer‐based design led to the development of powerful and highly selective compounds for inhibition of neuronal NOS over the other isozymes. After maternal administration in a rabbit model of CP, these compounds were found to distribute to fetal brain, to be nontoxic, without cardiovascular effects, inhibit fetal brain NOS activity in vivo, reduce NO concentration in fetal brain, and dramatically ameliorate deaths and number of newborn kits exhibiting signs of CP. Interpretation This approach may lead to new preventive strategies for CP. Ann Neurol 2008" @default.
- W2113179285 created "2016-06-24" @default.
- W2113179285 creator A5001723877 @default.
- W2113179285 creator A5002189428 @default.
- W2113179285 creator A5015585351 @default.
- W2113179285 creator A5015794500 @default.
- W2113179285 creator A5036064752 @default.
- W2113179285 creator A5040519455 @default.
- W2113179285 creator A5046305551 @default.
- W2113179285 creator A5064582120 @default.
- W2113179285 creator A5067253674 @default.
- W2113179285 creator A5068072087 @default.
- W2113179285 date "2009-02-01" @default.
- W2113179285 modified "2023-10-17" @default.
- W2113179285 title "Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy" @default.
- W2113179285 cites W1509196567 @default.
- W2113179285 cites W1667686291 @default.
- W2113179285 cites W1964421276 @default.
- W2113179285 cites W1966617758 @default.
- W2113179285 cites W1968659399 @default.
- W2113179285 cites W1972550441 @default.
- W2113179285 cites W1975941571 @default.
- W2113179285 cites W1979046104 @default.
- W2113179285 cites W1979589777 @default.
- W2113179285 cites W1979966800 @default.
- W2113179285 cites W1983401069 @default.
- W2113179285 cites W1989190357 @default.
- W2113179285 cites W1991484350 @default.
- W2113179285 cites W1998700502 @default.
- W2113179285 cites W1999466346 @default.
- W2113179285 cites W1999873010 @default.
- W2113179285 cites W2008517160 @default.
- W2113179285 cites W2012142152 @default.
- W2113179285 cites W2013083986 @default.
- W2113179285 cites W2014546878 @default.
- W2113179285 cites W2023078187 @default.
- W2113179285 cites W2026797052 @default.
- W2113179285 cites W2033495141 @default.
- W2113179285 cites W2036287757 @default.
- W2113179285 cites W2041124764 @default.
- W2113179285 cites W2044137193 @default.
- W2113179285 cites W2046258407 @default.
- W2113179285 cites W2054131864 @default.
- W2113179285 cites W2059577837 @default.
- W2113179285 cites W2064514012 @default.
- W2113179285 cites W2072975371 @default.
- W2113179285 cites W2075453410 @default.
- W2113179285 cites W2080653934 @default.
- W2113179285 cites W2085082260 @default.
- W2113179285 cites W2093517656 @default.
- W2113179285 cites W2094425038 @default.
- W2113179285 cites W2107424063 @default.
- W2113179285 cites W2126305917 @default.
- W2113179285 cites W2133126891 @default.
- W2113179285 cites W2135821537 @default.
- W2113179285 cites W2158534713 @default.
- W2113179285 cites W2164447377 @default.
- W2113179285 cites W2335544852 @default.
- W2113179285 cites W2599057497 @default.
- W2113179285 cites W4211262191 @default.
- W2113179285 doi "https://doi.org/10.1002/ana.21555" @default.
- W2113179285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2658647" @default.
- W2113179285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19235180" @default.
- W2113179285 hasPublicationYear "2009" @default.
- W2113179285 type Work @default.
- W2113179285 sameAs 2113179285 @default.
- W2113179285 citedByCount "68" @default.
- W2113179285 countsByYear W21131792852012 @default.
- W2113179285 countsByYear W21131792852013 @default.
- W2113179285 countsByYear W21131792852014 @default.
- W2113179285 countsByYear W21131792852015 @default.
- W2113179285 countsByYear W21131792852016 @default.
- W2113179285 countsByYear W21131792852017 @default.
- W2113179285 countsByYear W21131792852018 @default.
- W2113179285 countsByYear W21131792852019 @default.
- W2113179285 countsByYear W21131792852020 @default.
- W2113179285 countsByYear W21131792852021 @default.
- W2113179285 countsByYear W21131792852022 @default.
- W2113179285 countsByYear W21131792852023 @default.
- W2113179285 crossrefType "journal-article" @default.
- W2113179285 hasAuthorship W2113179285A5001723877 @default.
- W2113179285 hasAuthorship W2113179285A5002189428 @default.
- W2113179285 hasAuthorship W2113179285A5015585351 @default.
- W2113179285 hasAuthorship W2113179285A5015794500 @default.
- W2113179285 hasAuthorship W2113179285A5036064752 @default.
- W2113179285 hasAuthorship W2113179285A5040519455 @default.
- W2113179285 hasAuthorship W2113179285A5046305551 @default.
- W2113179285 hasAuthorship W2113179285A5064582120 @default.
- W2113179285 hasAuthorship W2113179285A5067253674 @default.
- W2113179285 hasAuthorship W2113179285A5068072087 @default.
- W2113179285 hasBestOaLocation W21131792852 @default.
- W2113179285 hasConcept C118552586 @default.
- W2113179285 hasConcept C126322002 @default.
- W2113179285 hasConcept C150903083 @default.
- W2113179285 hasConcept C172680121 @default.
- W2113179285 hasConcept C178790620 @default.
- W2113179285 hasConcept C185592680 @default.
- W2113179285 hasConcept C207001950 @default.