Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113181839> ?p ?o ?g. }
- W2113181839 endingPage "707" @default.
- W2113181839 startingPage "700" @default.
- W2113181839 abstract "Abstract . The presence of plasma proteins in the tubular lumen has variety of adverse effects on the tubular cells. Among various plasma proteins filtered through glomerular barrier, complement has been proven as the possible candidate inducing tubulointerstitial injury. To study the role of intratubular complement activation in proteinuric patients, complement activation products (CAP) at C3 level (iC3b and Bb) and C9 level (membrane attack complex) were measured in both plasma and urine of patients with minimal change nephrotic syndrome (MCNS), focal glomerular sclerosis, IgA nephropathy, membranous nephropathy, and diabetic nephropathy. For evaluation of the effect of metabolic acidosis on the intratubular complement activation, urinary CAP were measured before and after sodium bicarbonate administration in patients with renal insufficiency. The following results were obtained: ( 1 ) Patients with focal glomerular sclerosis and diabetic nephropathy showed the highest level of urinary CAP excretion rate (unit/creatinine), while MCNS revealed no increase. ( 2 ) Patients with membranous nephropathy showed a unique finding, i.e. , isolated increase of membrane attack complex excretion. ( 3 ) There was no significant correlation between urine and plasma levels of CAP. ( 4 ) Except for MCNS patients, the urinary excretion rate of CAP significantly increased when the level of proteinuria exceeded the nephrotic range, and it was significantly correlated with the serum creatinine level. ( 5 ) Urinary CAP excretion rate significantly decreased 2 wk after sodium bicarbonate administration without affecting the level of proteinuria or plasma CAP. These results suggest that the degree of intratubular complement activation correlates with the level of proteinuria, type of glomerular disease, impairment of renal function, and metabolic acidosis." @default.
- W2113181839 created "2016-06-24" @default.
- W2113181839 creator A5022137602 @default.
- W2113181839 creator A5025722039 @default.
- W2113181839 creator A5035166714 @default.
- W2113181839 creator A5045969631 @default.
- W2113181839 creator A5063678885 @default.
- W2113181839 creator A5073532773 @default.
- W2113181839 date "2000-04-01" @default.
- W2113181839 modified "2023-10-09" @default.
- W2113181839 title "Complement Activation Products in the Urine from Proteinuric Patients" @default.
- W2113181839 cites W1552888107 @default.
- W2113181839 cites W1964920299 @default.
- W2113181839 cites W1968303653 @default.
- W2113181839 cites W1976256121 @default.
- W2113181839 cites W1976367987 @default.
- W2113181839 cites W1981951415 @default.
- W2113181839 cites W1984419522 @default.
- W2113181839 cites W1987979328 @default.
- W2113181839 cites W1991446794 @default.
- W2113181839 cites W1992661118 @default.
- W2113181839 cites W1999572767 @default.
- W2113181839 cites W2008622887 @default.
- W2113181839 cites W2012231609 @default.
- W2113181839 cites W2018394477 @default.
- W2113181839 cites W2027931280 @default.
- W2113181839 cites W2035810126 @default.
- W2113181839 cites W2039312335 @default.
- W2113181839 cites W2041622229 @default.
- W2113181839 cites W2042063432 @default.
- W2113181839 cites W2048960863 @default.
- W2113181839 cites W2058669050 @default.
- W2113181839 cites W2071177681 @default.
- W2113181839 cites W2074563683 @default.
- W2113181839 cites W2075391935 @default.
- W2113181839 cites W2076406226 @default.
- W2113181839 cites W2081210113 @default.
- W2113181839 cites W2087151000 @default.
- W2113181839 cites W2092168816 @default.
- W2113181839 cites W2139335975 @default.
- W2113181839 cites W2142023207 @default.
- W2113181839 cites W2257503229 @default.
- W2113181839 cites W2286727159 @default.
- W2113181839 cites W2334279733 @default.
- W2113181839 cites W271729629 @default.
- W2113181839 cites W4299584742 @default.
- W2113181839 doi "https://doi.org/10.1681/asn.v114700" @default.
- W2113181839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10752529" @default.
- W2113181839 hasPublicationYear "2000" @default.
- W2113181839 type Work @default.
- W2113181839 sameAs 2113181839 @default.
- W2113181839 citedByCount "143" @default.
- W2113181839 countsByYear W21131818392012 @default.
- W2113181839 countsByYear W21131818392013 @default.
- W2113181839 countsByYear W21131818392014 @default.
- W2113181839 countsByYear W21131818392015 @default.
- W2113181839 countsByYear W21131818392016 @default.
- W2113181839 countsByYear W21131818392017 @default.
- W2113181839 countsByYear W21131818392018 @default.
- W2113181839 countsByYear W21131818392019 @default.
- W2113181839 countsByYear W21131818392020 @default.
- W2113181839 countsByYear W21131818392021 @default.
- W2113181839 countsByYear W21131818392022 @default.
- W2113181839 countsByYear W21131818392023 @default.
- W2113181839 crossrefType "journal-article" @default.
- W2113181839 hasAuthorship W2113181839A5022137602 @default.
- W2113181839 hasAuthorship W2113181839A5025722039 @default.
- W2113181839 hasAuthorship W2113181839A5035166714 @default.
- W2113181839 hasAuthorship W2113181839A5045969631 @default.
- W2113181839 hasAuthorship W2113181839A5063678885 @default.
- W2113181839 hasAuthorship W2113181839A5073532773 @default.
- W2113181839 hasBestOaLocation W21131818391 @default.
- W2113181839 hasConcept C104317684 @default.
- W2113181839 hasConcept C111684460 @default.
- W2113181839 hasConcept C112313634 @default.
- W2113181839 hasConcept C126322002 @default.
- W2113181839 hasConcept C126894567 @default.
- W2113181839 hasConcept C127716648 @default.
- W2113181839 hasConcept C159654299 @default.
- W2113181839 hasConcept C185592680 @default.
- W2113181839 hasConcept C188082640 @default.
- W2113181839 hasConcept C203014093 @default.
- W2113181839 hasConcept C2780026642 @default.
- W2113181839 hasConcept C55493867 @default.
- W2113181839 hasConcept C71924100 @default.
- W2113181839 hasConceptScore W2113181839C104317684 @default.
- W2113181839 hasConceptScore W2113181839C111684460 @default.
- W2113181839 hasConceptScore W2113181839C112313634 @default.
- W2113181839 hasConceptScore W2113181839C126322002 @default.
- W2113181839 hasConceptScore W2113181839C126894567 @default.
- W2113181839 hasConceptScore W2113181839C127716648 @default.
- W2113181839 hasConceptScore W2113181839C159654299 @default.
- W2113181839 hasConceptScore W2113181839C185592680 @default.
- W2113181839 hasConceptScore W2113181839C188082640 @default.
- W2113181839 hasConceptScore W2113181839C203014093 @default.
- W2113181839 hasConceptScore W2113181839C2780026642 @default.
- W2113181839 hasConceptScore W2113181839C55493867 @default.
- W2113181839 hasConceptScore W2113181839C71924100 @default.