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• W2113183222 abstract "P reeclampsia continues to represent a significant problem for both the obstetrician and the anesthesiologist. It affects 2% to 7% of all pregnancies in the United States and is likely to occur at both extremes of age [1]. A practitioner working in labor and delivery will be confronted with decisions regarding the management of these patients. Preeclampsia is a disorder that presents typically after 20 weeks gestation, most usually after 24 weeks, except when associated with a hydatidiform mole. Preeclampsia is currently diagnosed based on the classic triad of raised blood pressure, edema, and proteinuria. Of these symptoms, edema is the least specific. Proteinuria is defined as 30 mg/dL measured with a urine dipstick on two or more samples, or a total protein content of 300 mg or greater on a 24-hour urine collection [2]. The American College of Obstetricians and Gynecologists clinically defined preeclampsia as a sustained systolic blood pressure of at least 140 mm Hg or sustained diastolic blood pressure of 90 mm Hg [3]. Maternal and perinatal outcomes are good in patients who have mild preeclampsia developing after 36 weeks gestation. When preeclampsia develops before 33 weeks or in patients who have preexisting medical disorders, the outcome is less favorable [4]. Preeclampsia usually abates within 48 hours of pregnancy termination. Eclampsia is defined as preeclampsia with central nervous system involvement leading to seizures not related to other cerebral conditions. Severe preeclampsia involves end-organ damage. It is defined by the presence of preeclampsia and any one of the manifestations listed in Box 1. A parturient who has severe preeclampsia will be delivered regardless of the gestational age. Of preeclamptic parturients, only 1% will develop eclampsia. Given the risks associated with seizures, most parturients who have preeclampsia will be treated with magnesium to prevent seizures. In a multicenter trial comparing 5055 patients randomized to magnesium with 5055 treated with placebo, magnesium was the superior medication for preventing seizures [5]. Although patients treated with magnesium sulfate showed a greater" @default.
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• W2113183222 date "2008-10-01" @default.
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• W2113183222 title "Preeclampsia: What's New?" @default.
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• W2113183222 doi "https://doi.org/10.1016/j.aan.2008.07.002" @default.
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