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• W2113187612 abstract "A novel transdermal formulation of fentanyl‐containing dipropylene glycol droplets dispersed in a silicone matrix with a rate‐controlling membrane was developed. Healthy male subjects (n = 24) received repeated 72‐hour applications of fentanyl (50 μg/h) as the novel matrix and the conventional reservoir formulations in a randomized, 2‐way crossover study. Blood samples were collected, and serum concentrations of fentanyl were assayed using liquid chromatography with mass spectrometry detection. The mean area under the curve (AUCτ) and peak concentrations (C max ) of the matrix formulation were 84 838 pg·h/mL and 1680 pg/mL, respectively. Ratio and 90% confidence intervals of AUCτ and C max between the 2 formulations were within 80% to 125%. Adherence of the matrix formulation was higher than the reservoir formulation (62.5 vs 56.2%, P < .0001), without affecting skin irritation. Vital signs and adverse events of the 2 formulations were similar in nature and frequency. The novel matrix formulation displayed enhanced adherence and resulted in similar pharmacokinetics and tolerability as the reservoir formulation." @default.
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• W2113187612 date "2006-06-01" @default.
• W2113187612 modified "2023-10-17" @default.
• W2113187612 title "Pharmacokinetics, Tolerability, and Performance of a Novel Matrix Transdermal Delivery System of Fentanyl Relative to the Commercially Available Reservoir Formulation in Healthy Subjects" @default.
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• W2113187612 doi "https://doi.org/10.1177/0091270006286901" @default.
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