FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113191519> ?p ?o ?g. }

• W2113191519 endingPage "2467" @default.
• W2113191519 startingPage "2457" @default.
• W2113191519 abstract "Human cytomegalovirus (HCMV) infection results in endothelial dysfunction, typically known as dysregulated apoptosis, and aberrant expression and sub-cellular localization of p53, a tumor suppressor that accumulates at the late stage of infection. In this study, we examined three hypotheses that could be responsible for HCMV-induced cytoplasmic p53 accumulation at the later stage of infection: hyperactive nuclear export, cytoplasmic p53 tethering and delayed p53 degradation. Leptomycin B treatment, a nuclear export inhibitor, was unable to reduce cytoplasmic p53, thereby eliminating the hyperactive nuclear export mechanism. The findings that nascent p53 still entered nuclei after the nuclear export inhibition indicated that cytoplasmic tethering may play a minor role. Cytoplasmic p53 was still observed after the translation activities were blocked by cycloheximide. There was more than an eight-fold increase in the cytoplasmic p53 half-life with abnormal p53 ubiquitination. Taken together, these results suggest that delayed degradation could be responsible for the cytoplasmic p53 accumulation. The general slow-down of the proteasomal activity and the dysregulated p53 ubiquitination process at the later stage of infection could contribute to the reduced cytoplasmic p53 degradation and might be relevant to dysregulated endothelial apoptosis. The HCMV-induced changes in p53 dynamics could contribute to endothelial dysfunction." @default.
• W2113191519 created "2016-06-24" @default.
• W2113191519 creator A5005107318 @default.
• W2113191519 creator A5011440708 @default.
• W2113191519 creator A5017789225 @default.
• W2113191519 creator A5022675390 @default.
• W2113191519 creator A5026397262 @default.
• W2113191519 creator A5031400282 @default.
• W2113191519 creator A5032764121 @default.
• W2113191519 creator A5034632006 @default.
• W2113191519 creator A5036682185 @default.
• W2113191519 creator A5040245597 @default.
• W2113191519 creator A5049679614 @default.
• W2113191519 creator A5051727574 @default.
• W2113191519 creator A5071421730 @default.
• W2113191519 creator A5073333321 @default.
• W2113191519 creator A5083005456 @default.
• W2113191519 date "2006-06-15" @default.
• W2113191519 modified "2023-09-23" @default.
• W2113191519 title "Mechanisms for human cytomegalovirus-induced cytoplasmic p53 sequestration in endothelial cells" @default.
• W2113191519 cites W1611060217 @default.
• W2113191519 cites W1616121322 @default.
• W2113191519 cites W1623819487 @default.
• W2113191519 cites W1650797637 @default.
• W2113191519 cites W1856360008 @default.
• W2113191519 cites W1978518304 @default.
• W2113191519 cites W1982930031 @default.
• W2113191519 cites W1986179131 @default.
• W2113191519 cites W1993678833 @default.
• W2113191519 cites W2001124416 @default.
• W2113191519 cites W2012236491 @default.
• W2113191519 cites W2029317616 @default.
• W2113191519 cites W2030283142 @default.
• W2113191519 cites W2047317358 @default.
• W2113191519 cites W2048410022 @default.
• W2113191519 cites W2050745715 @default.
• W2113191519 cites W2051056834 @default.
• W2113191519 cites W2061404129 @default.
• W2113191519 cites W2073936529 @default.
• W2113191519 cites W2082979850 @default.
• W2113191519 cites W2083977776 @default.
• W2113191519 cites W2091025707 @default.
• W2113191519 cites W2094653142 @default.
• W2113191519 cites W2095402954 @default.
• W2113191519 cites W2095424116 @default.
• W2113191519 cites W2095732342 @default.
• W2113191519 cites W2103487477 @default.
• W2113191519 cites W2104398672 @default.
• W2113191519 cites W2107617257 @default.
• W2113191519 cites W2110942624 @default.
• W2113191519 cites W2114261502 @default.
• W2113191519 cites W2116265039 @default.
• W2113191519 cites W2117313136 @default.
• W2113191519 cites W2129954874 @default.
• W2113191519 cites W2133623775 @default.
• W2113191519 cites W2134907726 @default.
• W2113191519 cites W2134983040 @default.
• W2113191519 cites W2142299476 @default.
• W2113191519 cites W2143006836 @default.
• W2113191519 cites W2143206501 @default.
• W2113191519 cites W2153385610 @default.
• W2113191519 cites W2153728253 @default.
• W2113191519 cites W2154154520 @default.
• W2113191519 cites W2157952439 @default.
• W2113191519 cites W2160233843 @default.
• W2113191519 cites W2160345685 @default.
• W2113191519 cites W2167184679 @default.
• W2113191519 cites W2171258458 @default.
• W2113191519 cites W2171821593 @default.
• W2113191519 cites W2314987435 @default.
• W2113191519 doi "https://doi.org/10.1242/jcs.02974" @default.
• W2113191519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16720642" @default.
• W2113191519 hasPublicationYear "2006" @default.
• W2113191519 type Work @default.
• W2113191519 sameAs 2113191519 @default.
• W2113191519 citedByCount "17" @default.
• W2113191519 countsByYear W21131915192012 @default.
• W2113191519 countsByYear W21131915192013 @default.
• W2113191519 countsByYear W21131915192014 @default.
• W2113191519 countsByYear W21131915192016 @default.
• W2113191519 countsByYear W21131915192020 @default.
• W2113191519 countsByYear W21131915192022 @default.
• W2113191519 crossrefType "journal-article" @default.
• W2113191519 hasAuthorship W2113191519A5005107318 @default.
• W2113191519 hasAuthorship W2113191519A5011440708 @default.
• W2113191519 hasAuthorship W2113191519A5017789225 @default.
• W2113191519 hasAuthorship W2113191519A5022675390 @default.
• W2113191519 hasAuthorship W2113191519A5026397262 @default.
• W2113191519 hasAuthorship W2113191519A5031400282 @default.
• W2113191519 hasAuthorship W2113191519A5032764121 @default.
• W2113191519 hasAuthorship W2113191519A5034632006 @default.
• W2113191519 hasAuthorship W2113191519A5036682185 @default.
• W2113191519 hasAuthorship W2113191519A5040245597 @default.
• W2113191519 hasAuthorship W2113191519A5049679614 @default.
• W2113191519 hasAuthorship W2113191519A5051727574 @default.
• W2113191519 hasAuthorship W2113191519A5071421730 @default.
• W2113191519 hasAuthorship W2113191519A5073333321 @default.
• W2113191519 hasAuthorship W2113191519A5083005456 @default.

• next