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- W2113193872 abstract "The gastrointestinal microbiota is a major source of immune stimulation. The interaction between host pattern-recognition receptors and conserved microbial ligands profoundly influences infection dynamics. Identifying and understanding the nature of these interactions is a key step towards obtaining a clearer picture of microbial pathogenesis. These interactions underpin a complex interplay between microbe and host that has far reaching consequences for both. Here, we review the role of pattern recognition receptors in three prototype diseases affecting the stomach, the small intestine, and large intestine, respectively (Helicobacter pylori infection, Salmonella infection, and inflammatory bowel disease). Specifically, we review the nature and impact of pathogen:receptor interactions, their impact upon pathogenesis, and address the relevance of pattern recognition receptors in the development of therapies for gastrointestinal diseases." @default.
- W2113193872 created "2016-06-24" @default.
- W2113193872 creator A5058258257 @default.
- W2113193872 creator A5069439831 @default.
- W2113193872 creator A5088609553 @default.
- W2113193872 date "2011-01-01" @default.
- W2113193872 modified "2023-10-18" @default.
- W2113193872 title "Innate Immune Sensors and Gastrointestinal Bacterial Infections" @default.
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- W2113193872 doi "https://doi.org/10.1155/2011/579650" @default.
- W2113193872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3102448" @default.
- W2113193872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21647408" @default.
- W2113193872 hasPublicationYear "2011" @default.
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