FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113196818> ?p ?o ?g. }

• W2113196818 endingPage "479" @default.
• W2113196818 startingPage "468" @default.
• W2113196818 abstract "Genetic instability in relation to clinical behavior was studied in 52 cases of giant cell tumor of bone (GCTB). Ploidy was determined in the mononuclear cell population by using native cell smears and image cytometry. A relocalization technique allowed fluorescent in situ hybridization (FISH) analysis of CD68-negative neoplastic cells for numerical changes of chromosomes X, 3, 4, 6, 11, and telomeric association on 11p. Genome-wide alterations were tested using array comparative genomic hybridization (array-CGH) on magnetically separated CD68-negative tumor cells. CTNNB1, TP53, and BCL2 protein expression was also analyzed in formol-paraffin sections to see if their pathways are involved in the development of chromosomal instability. CD68-positive histiocytes showed no significant numerical chromosome and telomeric alterations. Based on ploidy values and clinical outcome, we could distinguish five groups as follows: diploid nonrecurrent (n = 20), tetraploid nonrecurrent (n = 6), diploid recurrent (n = 5), tetraploid and/or aneuploid recurrent (n = 14), and malignant cases (n = 7). Random individual-cell aneusomy was significantly (P < 0.001) more frequent in the recurrent groups (36.01 +/- 11.94%) than in the benign nonrecurrent cases (10.65 +/- 3.66%). The diploid recurrent group showed significantly (P < 0.001) increased balanced aneusomy compared with the diploid nonrecurrent group and the tetraploid nonrecurrent group represented eusomic polysomy. Array-CGH and FISH showed clonal aberrations almost exclusively in the malignant group. None of the protein markers tested showed significant correlation with elevated aneuploidy/polysomy (P = 0.56). Our results show that ploidy determination combined with FISH analysis may help predicting recurrence potential of GCTB and suggest that chromosomal abnormalities superimposed on telomeric associations could be responsible for an aggressive clinical course." @default.
• W2113196818 created "2016-06-24" @default.
• W2113196818 creator A5000144279 @default.
• W2113196818 creator A5003014435 @default.
• W2113196818 creator A5007028954 @default.
• W2113196818 creator A5011260122 @default.
• W2113196818 creator A5026089232 @default.
• W2113196818 creator A5048389934 @default.
• W2113196818 creator A5054757986 @default.
• W2113196818 creator A5070042273 @default.
• W2113196818 creator A5074366700 @default.
• W2113196818 date "2009-06-01" @default.
• W2113196818 modified "2023-10-16" @default.
• W2113196818 title "Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysis" @default.
• W2113196818 cites W1492065342 @default.
• W2113196818 cites W1944595112 @default.
• W2113196818 cites W1966815833 @default.
• W2113196818 cites W1967722049 @default.
• W2113196818 cites W1967985607 @default.
• W2113196818 cites W1969998785 @default.
• W2113196818 cites W1979036766 @default.
• W2113196818 cites W1979895440 @default.
• W2113196818 cites W1985010884 @default.
• W2113196818 cites W1993639393 @default.
• W2113196818 cites W2002628909 @default.
• W2113196818 cites W2012769053 @default.
• W2113196818 cites W2014646304 @default.
• W2113196818 cites W2015525292 @default.
• W2113196818 cites W2019614016 @default.
• W2113196818 cites W2022227305 @default.
• W2113196818 cites W2026522691 @default.
• W2113196818 cites W2029691061 @default.
• W2113196818 cites W2033107345 @default.
• W2113196818 cites W2044229396 @default.
• W2113196818 cites W2055615740 @default.
• W2113196818 cites W2057197190 @default.
• W2113196818 cites W2067953553 @default.
• W2113196818 cites W2082485483 @default.
• W2113196818 cites W2084198694 @default.
• W2113196818 cites W2088090766 @default.
• W2113196818 cites W2090769281 @default.
• W2113196818 cites W2091316799 @default.
• W2113196818 cites W2092858940 @default.
• W2113196818 cites W2100693390 @default.
• W2113196818 cites W2102680196 @default.
• W2113196818 cites W2112483686 @default.
• W2113196818 cites W2125554546 @default.
• W2113196818 cites W2128672071 @default.
• W2113196818 cites W2152044258 @default.
• W2113196818 cites W2155485025 @default.
• W2113196818 cites W2292974346 @default.
• W2113196818 cites W2989258869 @default.
• W2113196818 cites W4292542148 @default.
• W2113196818 cites W4322695778 @default.
• W2113196818 doi "https://doi.org/10.1002/gcc.20656" @default.
• W2113196818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19242928" @default.
• W2113196818 hasPublicationYear "2009" @default.
• W2113196818 type Work @default.
• W2113196818 sameAs 2113196818 @default.
• W2113196818 citedByCount "46" @default.
• W2113196818 countsByYear W21131968182012 @default.
• W2113196818 countsByYear W21131968182013 @default.
• W2113196818 countsByYear W21131968182014 @default.
• W2113196818 countsByYear W21131968182015 @default.
• W2113196818 countsByYear W21131968182016 @default.
• W2113196818 countsByYear W21131968182017 @default.
• W2113196818 countsByYear W21131968182018 @default.
• W2113196818 countsByYear W21131968182019 @default.
• W2113196818 countsByYear W21131968182020 @default.
• W2113196818 countsByYear W21131968182021 @default.
• W2113196818 countsByYear W21131968182022 @default.
• W2113196818 crossrefType "journal-article" @default.
• W2113196818 hasAuthorship W2113196818A5000144279 @default.
• W2113196818 hasAuthorship W2113196818A5003014435 @default.
• W2113196818 hasAuthorship W2113196818A5007028954 @default.
• W2113196818 hasAuthorship W2113196818A5011260122 @default.
• W2113196818 hasAuthorship W2113196818A5026089232 @default.
• W2113196818 hasAuthorship W2113196818A5048389934 @default.
• W2113196818 hasAuthorship W2113196818A5054757986 @default.
• W2113196818 hasAuthorship W2113196818A5070042273 @default.
• W2113196818 hasAuthorship W2113196818A5074366700 @default.
• W2113196818 hasConcept C104317684 @default.
• W2113196818 hasConcept C124942203 @default.
• W2113196818 hasConcept C140752955 @default.
• W2113196818 hasConcept C142724271 @default.
• W2113196818 hasConcept C143191323 @default.
• W2113196818 hasConcept C143425029 @default.
• W2113196818 hasConcept C153911025 @default.
• W2113196818 hasConcept C178169997 @default.
• W2113196818 hasConcept C2777542201 @default.
• W2113196818 hasConcept C2779672484 @default.
• W2113196818 hasConcept C2781303241 @default.
• W2113196818 hasConcept C30481170 @default.
• W2113196818 hasConcept C54355233 @default.
• W2113196818 hasConcept C552990157 @default.
• W2113196818 hasConcept C71924100 @default.
• W2113196818 hasConcept C86803240 @default.
• W2113196818 hasConceptScore W2113196818C104317684 @default.

• next