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- W2113200425 abstract "Objective: We pharmacologically characterized pituitary adenylate cyclase–activating polypeptides (PACAPs), vasoactive intestinal peptide (VIP) and the VPAC 1 , VPAC 2 and PAC 1 receptors in human meningeal (for their role in migraine) and coronary (for potential side effects) arteries. Methods: Concentration response curves to PACAP38, PACAP27, VIP and the VPAC 1 receptor agonist ([Lys15,Arg16,Leu27]-VIP[1-7]-GRF[8-27]) were constructed in the absence or presence of the PAC 1 receptor antagonist PACAP6-38 or the VPAC 1 receptor antagonist, PG97269. mRNA expression was measured using qPCR. Results: PACAP38 was less potent than VIP in both arteries. Both peptides had lower potency and efficacy in meningeal than in coronary arteries, while mRNA expression of VPAC 1 receptor was more pronounced in meningeal arteries. PACAP6-38 reduced the E max of PACAP27, while PG97269 right-shifted the VIP-induced relaxation curve only in the coronary arteries. Conclusion: The direct vasodilatory effect of VIP and PACAP might be less relevant than the central effect of this compound in migraine pathogenesis." @default.
- W2113200425 created "2016-06-24" @default.
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- W2113200425 date "2010-07-05" @default.
- W2113200425 modified "2023-10-16" @default.
- W2113200425 title "Pharmacological characterization of VIP and PACAP receptors in the human meningeal and coronary artery" @default.
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- W2113200425 doi "https://doi.org/10.1177/0333102410375624" @default.
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