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• W2113200857 abstract "I Ks , the slowly activating component of the delayed rectifier current, plays a major role in repolarization of the cardiac action potential (AP). Genetic mutations in the α- ( KCNQ1 ) and β- ( KCNE1 ) subunits of I Ks underlie Long QT Syndrome type 1 and 5 (LQT-1 and LQT-5), respectively, and predispose carriers to the development of polymorphic ventricular arrhythmias and sudden cardiac death. β-adrenergic stimulation increases I Ks and results in rate dependent AP shortening, a control system that can be disrupted by some mutations linked to LQT-1 and LQT-5. The mechanisms by which I Ks regulates action potential duration (APD) during β-adrenergic stimulation at different heart rates are not known, nor are the consequences of mutation induced disruption of this regulation. Here we develop a complementary experimental and theoretical approach to address these questions. We reconstituted I Ks in CHO cells (ie, KCNQ1 coexpressed with KCNE1 and the adaptator protein Yotiao) and quantitatively examined the effects of β-adrenergic stimulation on channel kinetics. We then developed theoretical models of I Ks in the absence and presence of β-adrenergic stimulation. We simulated the effects of sympathetic stimulation on channel activation (speeding) and deactivation (slowing) kinetics on the whole cell action potential under different pacing conditions. The model suggests these kinetic effects are critically important in rate-dependent control of action potential duration. We also investigate the effects of two LQT-5 mutations that alter kinetics and impair sympathetic stimulation of I Ks and show the likely mechanism by which they lead to tachyarrhythmias and indicate a distinct role of I KS kinetics in this electrical dysfunction. The full text of this article is available online at http://circres.ahajournals.org." @default.
• W2113200857 created "2016-06-24" @default.
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• W2113200857 date "2005-03-18" @default.
• W2113200857 modified "2023-10-14" @default.
• W2113200857 title "Autonomic Control of Cardiac Action Potentials" @default.
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• W2113200857 doi "https://doi.org/10.1161/01.res.0000160555.58046.9a" @default.
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