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• W2113201856 startingPage "319" @default.
• W2113201856 abstract "Polarized cells such as epithelial cells and neurons have distinct endosomal compartments associated with different plasma membrane domains. The endosomes of the neuronal cell body and the basolateral cytoplasm of epithelial cells are thought to perform cellular housekeeping functions such as the uptake of nutrients and metabolites, while the endosomes in the apical cytoplasm or axons are thought to be specialized for the sorting and transcytosis of cell type-specific ligands and receptors. However, it is not known if nonpolarized cells such as fibroblasts contain a specialized endosomal compartment analogous to the specialized endosomes found in neurons and epithelia. We have expressed a protein that is normally found in the apical early endosomes of developing intestinal epithelial cells in normal rat kidney fibroblasts. This apical endosomal marker, called endotubin, is targeted to early endosomes in transfected fibroblasts, and is present in peripheral as well as perinuclear endosomes. The peripheral endosomes that contain endotubin appear to exclude transferrin, fluid phase markers, and the mannose-6-phosphate receptor, although in the perinuclear region colocalization of endotubin and these markers is present. In addition, endotubin positive structures do not tubulate in response to brefeldin A and instead redistribute to a diffuse perinuclear location. Since this endosomal compartment has many of the characteristics of an apical or axonal endosomal compartment, our results indicate that nonpolarized cells also contain a specialized early endosomal compartment." @default.
• W2113201856 created "2016-06-24" @default.
• W2113201856 creator A5000573702 @default.
• W2113201856 creator A5055646523 @default.
• W2113201856 date "1997-01-27" @default.
• W2113201856 modified "2023-09-27" @default.
• W2113201856 title "Targeting of an Intestinal Apical Endosomal Protein to Endosomes in Nonpolarized Cells" @default.
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• W2113201856 doi "https://doi.org/10.1083/jcb.136.2.319" @default.
• W2113201856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2134826" @default.
• W2113201856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9015303" @default.
• W2113201856 hasPublicationYear "1997" @default.
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