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• W2113206388 abstract "OBJECTIVES To examine the distribution of striatal dopaminergic function in humans with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to determine if there is a caudate-putamen gradient as is seen in idiopathic Parkinson's disease. METHODS We scanned nine humans exposed to MPTP with parkinsonism ranging from minimal to severe using [18F]fluorodopa (FD) and high resolution PET. The results were compared with those of 10 patients with Parkinson's disease and six normal subjects. RESULTS In the MPTP group there was an equal degree of reduction of dopaminergic function in the caudate and putamen. This was different from the greater putaminal than caudate loss in Parkinson's disease (p<0.001). CONCLUSIONS Parkinson's disease is not caused by transient exposure to MPTP." @default.
• W2113206388 created "2016-06-24" @default.
• W2113206388 creator A5015382924 @default.
• W2113206388 date "2000-03-01" @default.
• W2113206388 modified "2023-10-17" @default.
• W2113206388 title "Pattern of dopaminergic loss in the striatum of humans with MPTP induced parkinsonism" @default.
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• W2113206388 doi "https://doi.org/10.1136/jnnp.68.3.313" @default.
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