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• W2113206822 startingPage "615" @default.
• W2113206822 abstract "Infectious Diseases Society of America guidelines state that uncomplicated urinary tract infections (UTIs) should be treated empirically with trimethoprim-sulfamethoxazole (TMP-SMZ), unless the community resistance among uropathogens exceeds 10%-20%, in which case a fluoroquinolone (FQ) should be used. However, the data to support this threshold are limited. We performed a cost-minimization and sensitivity analysis to determine what level of TMP-SMZ resistance in a community should trigger FQ use. The mean cost of empirical treatment with TMP-SMZ was US$92 when the proportion of resistant Escherichia coli was 0%, $106 when it was 20%, and $120 when it was 40%. The mean cost of empirical FQ treatment was $107 at current levels of FQ resistance. When >22% of E. coli in a community are TMP-SMZ-resistant, empirical FQ therapy becomes less costly than TMP-SMZ therapy. Treatment guidelines for empirical treatment of UTIs may need modification, and the threshold trigger for empirical FQ use should be raised to >20% TMP-SMZ resistance." @default.
• W2113206822 created "2016-06-24" @default.
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• W2113206822 creator A5047313316 @default.
• W2113206822 date "2001-09-01" @default.
• W2113206822 modified "2023-09-27" @default.
• W2113206822 title "Empirical Therapy for Uncomplicated Urinary Tract Infections in an Era of Increasing Antimicrobial Resistance: A Decision and Cost Analysis" @default.
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• W2113206822 doi "https://doi.org/10.1086/322603" @default.
• W2113206822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11486284" @default.
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