Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113207478> ?p ?o ?g. }
- W2113207478 endingPage "187" @default.
- W2113207478 startingPage "181" @default.
- W2113207478 abstract "Although mortality from colorectal cancer (CRC) is decreasing, CRC is still the second highest cause of cancer-related deaths in America. Chemotherapy and radiation therapy now have central roles in our strategies to fight cancer, although we continue to lack novel strategies overcoming therapeutic resistance. Molecular mechanisms of therapeutic resistance in CRC continue to be under intense investigation. In this review, we highlight the recent evidence linking epithelial-to-mesenchymal transition (EMT) with aggressive tumor biology as well as with the cancer stem cells (CSCs) across multiple organ systems including colon cancer. Furthermore, in the era of neo-adjuvant treatment, the clinical implications are concerning that our treatments may have the potential to induce more aggressive cancer cells through EMT, perhaps even generating CSCs more capable of metastasis and further resistant to treatment. This concern and potential reality highlights the critical need for further understanding the impact of clinical therapy on the pathobiology of cancer and further supports the need to therapeutically target the CSC. Besides serving as potential biomarkers for aggressive tumor biology and therapeutic resistance, EMT and CSC molecular pathways may highlight novel therapeutic targets as strategies for improving the response to conventional anti-neoplastic agents translating into improved oncologic outcomes." @default.
- W2113207478 created "2016-06-24" @default.
- W2113207478 creator A5000527734 @default.
- W2113207478 creator A5022537592 @default.
- W2113207478 creator A5033762927 @default.
- W2113207478 creator A5055880560 @default.
- W2113207478 date "2014-05-01" @default.
- W2113207478 modified "2023-10-14" @default.
- W2113207478 title "Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer" @default.
- W2113207478 cites W1607272355 @default.
- W2113207478 cites W1964405387 @default.
- W2113207478 cites W1965822047 @default.
- W2113207478 cites W1969671165 @default.
- W2113207478 cites W1971624340 @default.
- W2113207478 cites W1973101195 @default.
- W2113207478 cites W1975916185 @default.
- W2113207478 cites W1976324983 @default.
- W2113207478 cites W1979421565 @default.
- W2113207478 cites W1983961550 @default.
- W2113207478 cites W1983991097 @default.
- W2113207478 cites W1988218110 @default.
- W2113207478 cites W1998166198 @default.
- W2113207478 cites W2001031858 @default.
- W2113207478 cites W2001258296 @default.
- W2113207478 cites W2001544973 @default.
- W2113207478 cites W2002695314 @default.
- W2113207478 cites W2003003147 @default.
- W2113207478 cites W2003727125 @default.
- W2113207478 cites W2008555392 @default.
- W2113207478 cites W2009886857 @default.
- W2113207478 cites W2010980929 @default.
- W2113207478 cites W2012063336 @default.
- W2113207478 cites W2014691022 @default.
- W2113207478 cites W2018263869 @default.
- W2113207478 cites W2019264784 @default.
- W2113207478 cites W2023427658 @default.
- W2113207478 cites W2023560061 @default.
- W2113207478 cites W2026084555 @default.
- W2113207478 cites W2029231546 @default.
- W2113207478 cites W2031210616 @default.
- W2113207478 cites W2031621381 @default.
- W2113207478 cites W2031770999 @default.
- W2113207478 cites W2040660199 @default.
- W2113207478 cites W2042198997 @default.
- W2113207478 cites W2043046186 @default.
- W2113207478 cites W2045755466 @default.
- W2113207478 cites W2047992261 @default.
- W2113207478 cites W2050212958 @default.
- W2113207478 cites W2050300062 @default.
- W2113207478 cites W2051055358 @default.
- W2113207478 cites W2053720936 @default.
- W2113207478 cites W2056041663 @default.
- W2113207478 cites W2056302937 @default.
- W2113207478 cites W2060551076 @default.
- W2113207478 cites W2061876263 @default.
- W2113207478 cites W2064387879 @default.
- W2113207478 cites W2066633590 @default.
- W2113207478 cites W2068910226 @default.
- W2113207478 cites W2069009920 @default.
- W2113207478 cites W2069831652 @default.
- W2113207478 cites W2073759231 @default.
- W2113207478 cites W2074664629 @default.
- W2113207478 cites W2074679319 @default.
- W2113207478 cites W2077580185 @default.
- W2113207478 cites W2081447858 @default.
- W2113207478 cites W2083381199 @default.
- W2113207478 cites W2087367170 @default.
- W2113207478 cites W2088153666 @default.
- W2113207478 cites W2094572856 @default.
- W2113207478 cites W2097308038 @default.
- W2113207478 cites W2099692224 @default.
- W2113207478 cites W2103033566 @default.
- W2113207478 cites W2109998353 @default.
- W2113207478 cites W2110610232 @default.
- W2113207478 cites W2110937119 @default.
- W2113207478 cites W2111599976 @default.
- W2113207478 cites W2111783800 @default.
- W2113207478 cites W2112420045 @default.
- W2113207478 cites W2118758371 @default.
- W2113207478 cites W2118983280 @default.
- W2113207478 cites W2119492915 @default.
- W2113207478 cites W2120622571 @default.
- W2113207478 cites W2120656656 @default.
- W2113207478 cites W2123027432 @default.
- W2113207478 cites W2125292576 @default.
- W2113207478 cites W2125452425 @default.
- W2113207478 cites W2125747634 @default.
- W2113207478 cites W2125987139 @default.
- W2113207478 cites W2126002765 @default.
- W2113207478 cites W2129355962 @default.
- W2113207478 cites W2137048052 @default.
- W2113207478 cites W2139151018 @default.
- W2113207478 cites W2139544398 @default.
- W2113207478 cites W2140551998 @default.
- W2113207478 cites W2141448895 @default.
- W2113207478 cites W2142807621 @default.
- W2113207478 cites W2143655828 @default.
- W2113207478 cites W2147787153 @default.