FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113207830> ?p ?o ?g. }

• W2113207830 endingPage "108" @default.
• W2113207830 startingPage "97" @default.
• W2113207830 abstract "Despite the claim in the published literature, the introduction of proton therapy for children is not analogous to the evolution of conformal photon irradiation relying on the understanding of the impact of altered dose distributions. The differences in radiobiological effect when comparing photons with protons mean that we are comparing a known entity with an unknown entity: the dose-volume histogram for proton therapy might mean something substantially different from the dose-volume histogram for photon therapy. The multifaceted difference between the 2 modalities supports the argument for careful evaluation, follow-up, and clinical trials with adverse event monitoring when using proton therapy in children. We review the current data on the outcome of proton therapy in a range of pediatric tumors and compare them with the often excellent results of photon therapy in the setting of multidisciplinary management of childhood cancer. It is hoped that the apparent dosimetric advantage of proton therapy over photons will lead to improved indications for therapy, disease control, and functional outcomes. Although physical dose distribution is of clear importance, the multimodality management of children by an expert pediatric oncology team and the availability of ancillary measures that improve the quality of treatment delivery may be more important than the actual beam. In addition, current estimates of the benefit of proton therapy over photon therapy based on toxicity reduction will only be realized when survivorship has been achieved. Once substantive proton therapy data become available, it will be necessary to demonstrate benefit in clinically relevant outcome measures in comparison with best existing photon outcome data. Such an effort will require improved funding and appreciation for late effects research. Only real clinical outcome data combined with better understanding of the radiobiological differences between protons and photons will help us to further reduce side effects in children and exploit the full curative potential of this relatively new modality." @default.
• W2113207830 created "2016-06-24" @default.
• W2113207830 creator A5006930070 @default.
• W2113207830 date "2013-04-01" @default.
• W2113207830 modified "2023-09-25" @default.
• W2113207830 title "Clinical Controversies: Proton Therapy for Pediatric Tumors" @default.
• W2113207830 cites W1518853687 @default.
• W2113207830 cites W1843771850 @default.
• W2113207830 cites W1971742491 @default.
• W2113207830 cites W1974021394 @default.
• W2113207830 cites W1977017369 @default.
• W2113207830 cites W1980879738 @default.
• W2113207830 cites W1982362383 @default.
• W2113207830 cites W1982541720 @default.
• W2113207830 cites W1983805637 @default.
• W2113207830 cites W2004381237 @default.
• W2113207830 cites W2006730908 @default.
• W2113207830 cites W2007015638 @default.
• W2113207830 cites W2008084546 @default.
• W2113207830 cites W2009174295 @default.
• W2113207830 cites W2009347508 @default.
• W2113207830 cites W2013862573 @default.
• W2113207830 cites W2014084887 @default.
• W2113207830 cites W2015773555 @default.
• W2113207830 cites W2016494784 @default.
• W2113207830 cites W2017872025 @default.
• W2113207830 cites W2030980212 @default.
• W2113207830 cites W2034914406 @default.
• W2113207830 cites W2036167723 @default.
• W2113207830 cites W2037154100 @default.
• W2113207830 cites W2068079626 @default.
• W2113207830 cites W2071052715 @default.
• W2113207830 cites W2071155486 @default.
• W2113207830 cites W2072087143 @default.
• W2113207830 cites W2073632607 @default.
• W2113207830 cites W2075635563 @default.
• W2113207830 cites W2077331155 @default.
• W2113207830 cites W2077506633 @default.
• W2113207830 cites W2078028017 @default.
• W2113207830 cites W2079126085 @default.
• W2113207830 cites W2104484857 @default.
• W2113207830 cites W2106921779 @default.
• W2113207830 cites W2123759275 @default.
• W2113207830 cites W2124143747 @default.
• W2113207830 cites W2124232983 @default.
• W2113207830 cites W2127148395 @default.
• W2113207830 cites W2132875097 @default.
• W2113207830 cites W2136533499 @default.
• W2113207830 cites W2138575100 @default.
• W2113207830 cites W2141969313 @default.
• W2113207830 cites W2143861595 @default.
• W2113207830 cites W2151545367 @default.
• W2113207830 cites W2152329005 @default.
• W2113207830 cites W2152371035 @default.
• W2113207830 cites W2154650708 @default.
• W2113207830 cites W2160979741 @default.
• W2113207830 cites W2162695324 @default.
• W2113207830 cites W2165948908 @default.
• W2113207830 doi "https://doi.org/10.1016/j.semradonc.2012.11.008" @default.
• W2113207830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3595134" @default.
• W2113207830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23473686" @default.
• W2113207830 hasPublicationYear "2013" @default.
• W2113207830 type Work @default.
• W2113207830 sameAs 2113207830 @default.
• W2113207830 citedByCount "67" @default.
• W2113207830 countsByYear W21132078302013 @default.
• W2113207830 countsByYear W21132078302014 @default.
• W2113207830 countsByYear W21132078302015 @default.
• W2113207830 countsByYear W21132078302016 @default.
• W2113207830 countsByYear W21132078302017 @default.
• W2113207830 countsByYear W21132078302018 @default.
• W2113207830 countsByYear W21132078302019 @default.
• W2113207830 countsByYear W21132078302020 @default.
• W2113207830 countsByYear W21132078302021 @default.
• W2113207830 countsByYear W21132078302022 @default.
• W2113207830 countsByYear W21132078302023 @default.
• W2113207830 crossrefType "journal-article" @default.
• W2113207830 hasAuthorship W2113207830A5006930070 @default.
• W2113207830 hasBestOaLocation W21132078302 @default.
• W2113207830 hasConcept C126838900 @default.
• W2113207830 hasConcept C177713679 @default.
• W2113207830 hasConcept C19527891 @default.
• W2113207830 hasConcept C2778418280 @default.
• W2113207830 hasConcept C2779244869 @default.
• W2113207830 hasConcept C509974204 @default.
• W2113207830 hasConcept C71924100 @default.
• W2113207830 hasConceptScore W2113207830C126838900 @default.
• W2113207830 hasConceptScore W2113207830C177713679 @default.
• W2113207830 hasConceptScore W2113207830C19527891 @default.
• W2113207830 hasConceptScore W2113207830C2778418280 @default.
• W2113207830 hasConceptScore W2113207830C2779244869 @default.
• W2113207830 hasConceptScore W2113207830C509974204 @default.
• W2113207830 hasConceptScore W2113207830C71924100 @default.
• W2113207830 hasIssue "2" @default.
• W2113207830 hasLocation W21132078301 @default.
• W2113207830 hasLocation W21132078302 @default.
• W2113207830 hasLocation W21132078303 @default.
• W2113207830 hasLocation W21132078304 @default.

• next