FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113207934> ?p ?o ?g. }

• W2113207934 endingPage "287" @default.
• W2113207934 startingPage "282" @default.
• W2113207934 abstract "Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of matrix metalloproteinases. In this study, we have characterized lipocyte expression and release of tissue inhibitor of metalloproteinases-1 (TIMP-1), an important inhibitor of metalloproteinase activity, whose role in liver has not previously been examined. TIMP-1 was immunolocalized to human lipocytes, and secretion of TIMP-1 was confirmed by ELISA of culture media; (mean +/- SD) 159 +/- 79 ng of TIMP-1/10(6) cells per 24 h. Evidence for functional inhibitory activity of released TIMP-1 was obtained by (a) reverse zymography that demonstrated a single inhibitor band, M(r) 28 kD, that co-migrated with a TIMP-1-positive control sample; and (b) unmasking of inhibited gelatinase activity in lipocyte medium by separating it from TIMP-1 using gelatin sepharose chromatography; gelatinase activity in chromatographed medium increased more than 20-fold, compared with unfractionated medium, and could be reinhibited by adding back fractions that contained inhibitor. By Northern analysis, freshly isolated human lipocytes exhibited low levels of mRNA expression for TIMP-1, but this increased markedly relative to beta-actin expression with lipocyte activation during cell culture. We conclude that human hepatic lipocytes synthesize TIMP-1, a potent metalloproteinase inhibitor, and that TIMP-1 expression increases with lipocyte activation. These data indicate that hepatic lipocytes can regulate matrix degradation in the liver, and suggest that expression of TIMP-1 by activated lipocytes may contribute to the progression of liver fibrosis." @default.
• W2113207934 created "2016-06-24" @default.
• W2113207934 creator A5005005761 @default.
• W2113207934 creator A5016235541 @default.
• W2113207934 creator A5040740891 @default.
• W2113207934 creator A5048755383 @default.
• W2113207934 creator A5076560982 @default.
• W2113207934 date "1992-07-01" @default.
• W2113207934 modified "2023-09-26" @default.
• W2113207934 title "Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver." @default.
• W2113207934 cites W1461140577 @default.
• W2113207934 cites W1510586846 @default.
• W2113207934 cites W1520141791 @default.
• W2113207934 cites W1530150767 @default.
• W2113207934 cites W1537193766 @default.
• W2113207934 cites W1598270217 @default.
• W2113207934 cites W1600831053 @default.
• W2113207934 cites W1784780697 @default.
• W2113207934 cites W2000903132 @default.
• W2113207934 cites W2008391092 @default.
• W2113207934 cites W2010846405 @default.
• W2113207934 cites W2012050910 @default.
• W2113207934 cites W2012349920 @default.
• W2113207934 cites W2017521887 @default.
• W2113207934 cites W2030770727 @default.
• W2113207934 cites W2031717125 @default.
• W2113207934 cites W205278663 @default.
• W2113207934 cites W2084164842 @default.
• W2113207934 cites W2088071075 @default.
• W2113207934 cites W2112426232 @default.
• W2113207934 cites W2129984889 @default.
• W2113207934 cites W2134812217 @default.
• W2113207934 cites W2136002823 @default.
• W2113207934 cites W2136873073 @default.
• W2113207934 cites W2138954731 @default.
• W2113207934 cites W2149139187 @default.
• W2113207934 cites W2320355698 @default.
• W2113207934 cites W2409948780 @default.
• W2113207934 cites W2429128221 @default.
• W2113207934 cites W2432056437 @default.
• W2113207934 cites W67171789 @default.
• W2113207934 cites W83654762 @default.
• W2113207934 doi "https://doi.org/10.1172/jci115850" @default.
• W2113207934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/443094" @default.
• W2113207934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1634616" @default.
• W2113207934 hasPublicationYear "1992" @default.
• W2113207934 type Work @default.
• W2113207934 sameAs 2113207934 @default.
• W2113207934 citedByCount "198" @default.
• W2113207934 countsByYear W21132079342012 @default.
• W2113207934 countsByYear W21132079342013 @default.
• W2113207934 countsByYear W21132079342014 @default.
• W2113207934 countsByYear W21132079342016 @default.
• W2113207934 countsByYear W21132079342017 @default.
• W2113207934 countsByYear W21132079342018 @default.
• W2113207934 countsByYear W21132079342020 @default.
• W2113207934 countsByYear W21132079342021 @default.
• W2113207934 countsByYear W21132079342022 @default.
• W2113207934 countsByYear W21132079342023 @default.
• W2113207934 crossrefType "journal-article" @default.
• W2113207934 hasAuthorship W2113207934A5005005761 @default.
• W2113207934 hasAuthorship W2113207934A5016235541 @default.
• W2113207934 hasAuthorship W2113207934A5040740891 @default.
• W2113207934 hasAuthorship W2113207934A5048755383 @default.
• W2113207934 hasAuthorship W2113207934A5076560982 @default.
• W2113207934 hasBestOaLocation W21132079341 @default.
• W2113207934 hasConcept C109523444 @default.
• W2113207934 hasConcept C126322002 @default.
• W2113207934 hasConcept C134018914 @default.
• W2113207934 hasConcept C153911025 @default.
• W2113207934 hasConcept C176891718 @default.
• W2113207934 hasConcept C177430391 @default.
• W2113207934 hasConcept C181199279 @default.
• W2113207934 hasConcept C185592680 @default.
• W2113207934 hasConcept C189165786 @default.
• W2113207934 hasConcept C2775965246 @default.
• W2113207934 hasConcept C2776223131 @default.
• W2113207934 hasConcept C2776232661 @default.
• W2113207934 hasConcept C2776747403 @default.
• W2113207934 hasConcept C2778394429 @default.
• W2113207934 hasConcept C2780381497 @default.
• W2113207934 hasConcept C2780559512 @default.
• W2113207934 hasConcept C54355233 @default.
• W2113207934 hasConcept C55493867 @default.
• W2113207934 hasConcept C71924100 @default.
• W2113207934 hasConcept C81885089 @default.
• W2113207934 hasConcept C86803240 @default.
• W2113207934 hasConceptScore W2113207934C109523444 @default.
• W2113207934 hasConceptScore W2113207934C126322002 @default.
• W2113207934 hasConceptScore W2113207934C134018914 @default.
• W2113207934 hasConceptScore W2113207934C153911025 @default.
• W2113207934 hasConceptScore W2113207934C176891718 @default.
• W2113207934 hasConceptScore W2113207934C177430391 @default.
• W2113207934 hasConceptScore W2113207934C181199279 @default.
• W2113207934 hasConceptScore W2113207934C185592680 @default.
• W2113207934 hasConceptScore W2113207934C189165786 @default.
• W2113207934 hasConceptScore W2113207934C2775965246 @default.
• W2113207934 hasConceptScore W2113207934C2776223131 @default.

• next