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• W2113208497 abstract "Objectives: The current analysis investigated the onset of antidepressant effect of olanzapine/fluoxetine combination. Methods: Data for these post hoc analyses were obtained from a clinical trial comparing olanzapine, placebo, and olanzapine/fluoxetine combination in bipolar depression (BD). Subjects were 833 patients with a DSM‐IV diagnosis of bipolar I disorder, depressed. The Montgomery–Åsberg Depression Rating Scale measured depressive symptoms. Multiple analytic methods were applied, including traditional (mean differences) analysis, pattern analysis, survival analysis of sustained response, mixed‐effects regression, and area‐under‐the‐curve analysis. Results: Traditional analysis showed significantly greater improvement in depression scores at week 1 for olanzapine/fluoxetine combination versus placebo (−9.55 versus −5.08, p < 0.001) and for olanzapine versus placebo (−8.31 versus −5.08, p < 0.001). Pattern analysis revealed olanzapine/fluoxetine combination had a significantly greater percentage of early persistent responders than placebo or olanzapine (32.4% versus 12.7%, p < 0.001; and 18.3%, p < 0.05, respectively). Survival analysis showed a significantly shorter time to sustained response for the combination versus placebo (p < 0.001), for olanzapine versus placebo (p = 0.04), and for the combination versus olanzapine (p = 0.03). Mixed‐effects regression analysis revealed a significant therapy‐by‐time interaction (p < 0.001). Early area‐under‐the‐curve analysis revealed a significantly greater percentage of improvement for the combination versus placebo (26.7% versus 13.9%, p < 0.001) and for olanzapine versus placebo (22.0% versus 13.9%, p < 0.001). Conclusions: Based on consistent results from related methods of measuring onset, olanzapine/fluoxetine combination demonstrated rapid onset of antidepressant effect (within 7 days) compared to placebo that was sustained over 8 weeks of treatment in a sample of BD patients. Using multiple statistical techniques may help profile a drug's onset of effect." @default.
• W2113208497 created "2016-06-24" @default.
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• W2113208497 date "2007-09-01" @default.
• W2113208497 modified "2023-10-11" @default.
• W2113208497 title "Onset of antidepressant effect of olanzapine and olanzapine/fluoxetine combination in bipolar depression" @default.
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• W2113208497 doi "https://doi.org/10.1111/j.1399-5618.2007.00491.x" @default.
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