FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113209997> ?p ?o ?g. }

• W2113209997 endingPage "855" @default.
• W2113209997 startingPage "849" @default.
• W2113209997 abstract "Recently, a debate has emerged on the use and necessity of standardization in experimental testing using animal subjects. The difficulties encountered when trying to reconcile standardization and generalization largely underlie this debate. The more specific the testing procedures are, the less one can generalize to more naturalistic situations, including to human clinical populations. If the goal of a study is to generalize to a larger population, there may be a higher risk attached to false-positive than false-negative results; thus the balance sways toward generalization. Heterogenization of housing conditions and of genetic makeup of experimental animals has been suggested as a possible method to increase the generalizability of results. It is important to remain cognizant, however, of situations in which false negatives can be counterproductive or even dangerous, such as when the goal is to elucidate a physiological mechanism, when expected effect sizes are small, in toxicological studies and in drug safety testing. In such cases, experiments based on standardization may provide more useful information. We pose that it is essential that the goal of the specific experiment conducted is clearly defined and that the decision to balance between standardization and generalization must be made based on the specific needs to meet the intended goal. In this light, we discuss a multi-tiered approach to animal experimentation, in which standardization and generalizability are each given precedence during different phases of a project, depending upon the goal of the experiment." @default.
• W2113209997 created "2016-06-24" @default.
• W2113209997 creator A5022063104 @default.
• W2113209997 creator A5044470441 @default.
• W2113209997 creator A5054761193 @default.
• W2113209997 date "2010-11-01" @default.
• W2113209997 modified "2023-10-06" @default.
• W2113209997 title "The standardization-generalization dilemma: a way out" @default.
• W2113209997 cites W1552728147 @default.
• W2113209997 cites W1964858687 @default.
• W2113209997 cites W1968492230 @default.
• W2113209997 cites W1976624377 @default.
• W2113209997 cites W1978444428 @default.
• W2113209997 cites W1980564630 @default.
• W2113209997 cites W1982790235 @default.
• W2113209997 cites W1983890419 @default.
• W2113209997 cites W1985359371 @default.
• W2113209997 cites W1987024617 @default.
• W2113209997 cites W2002752938 @default.
• W2113209997 cites W2021458971 @default.
• W2113209997 cites W2029707852 @default.
• W2113209997 cites W2030136684 @default.
• W2113209997 cites W2030299914 @default.
• W2113209997 cites W2060216174 @default.
• W2113209997 cites W2067733742 @default.
• W2113209997 cites W2071407374 @default.
• W2113209997 cites W2079797345 @default.
• W2113209997 cites W2085329742 @default.
• W2113209997 cites W2085830154 @default.
• W2113209997 cites W2087484885 @default.
• W2113209997 cites W2087568219 @default.
• W2113209997 cites W2090056437 @default.
• W2113209997 cites W2091763576 @default.
• W2113209997 cites W2093519059 @default.
• W2113209997 cites W2103752548 @default.
• W2113209997 cites W2123644333 @default.
• W2113209997 cites W2131405716 @default.
• W2113209997 cites W2132058857 @default.
• W2113209997 cites W2134561732 @default.
• W2113209997 cites W2143344601 @default.
• W2113209997 cites W2153153786 @default.
• W2113209997 cites W2154494913 @default.
• W2113209997 cites W2161147746 @default.
• W2113209997 cites W2166633909 @default.
• W2113209997 cites W2168400200 @default.
• W2113209997 cites W2168795031 @default.
• W2113209997 cites W4210989921 @default.
• W2113209997 cites W4232702928 @default.
• W2113209997 cites W2042901987 @default.
• W2113209997 doi "https://doi.org/10.1111/j.1601-183x.2010.00628.x" @default.
• W2113209997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20662940" @default.
• W2113209997 hasPublicationYear "2010" @default.
• W2113209997 type Work @default.
• W2113209997 sameAs 2113209997 @default.
• W2113209997 citedByCount "38" @default.
• W2113209997 countsByYear W21132099972012 @default.
• W2113209997 countsByYear W21132099972013 @default.
• W2113209997 countsByYear W21132099972014 @default.
• W2113209997 countsByYear W21132099972015 @default.
• W2113209997 countsByYear W21132099972016 @default.
• W2113209997 countsByYear W21132099972017 @default.
• W2113209997 countsByYear W21132099972018 @default.
• W2113209997 countsByYear W21132099972019 @default.
• W2113209997 countsByYear W21132099972020 @default.
• W2113209997 countsByYear W21132099972021 @default.
• W2113209997 countsByYear W21132099972022 @default.
• W2113209997 countsByYear W21132099972023 @default.
• W2113209997 crossrefType "journal-article" @default.
• W2113209997 hasAuthorship W2113209997A5022063104 @default.
• W2113209997 hasAuthorship W2113209997A5044470441 @default.
• W2113209997 hasAuthorship W2113209997A5054761193 @default.
• W2113209997 hasConcept C111472728 @default.
• W2113209997 hasConcept C111919701 @default.
• W2113209997 hasConcept C112930515 @default.
• W2113209997 hasConcept C134306372 @default.
• W2113209997 hasConcept C138496976 @default.
• W2113209997 hasConcept C138885662 @default.
• W2113209997 hasConcept C15744967 @default.
• W2113209997 hasConcept C177148314 @default.
• W2113209997 hasConcept C188087704 @default.
• W2113209997 hasConcept C2524010 @default.
• W2113209997 hasConcept C27158222 @default.
• W2113209997 hasConcept C2778496695 @default.
• W2113209997 hasConcept C33923547 @default.
• W2113209997 hasConcept C41008148 @default.
• W2113209997 hasConcept C71924100 @default.
• W2113209997 hasConcept C89611455 @default.
• W2113209997 hasConceptScore W2113209997C111472728 @default.
• W2113209997 hasConceptScore W2113209997C111919701 @default.
• W2113209997 hasConceptScore W2113209997C112930515 @default.
• W2113209997 hasConceptScore W2113209997C134306372 @default.
• W2113209997 hasConceptScore W2113209997C138496976 @default.
• W2113209997 hasConceptScore W2113209997C138885662 @default.
• W2113209997 hasConceptScore W2113209997C15744967 @default.
• W2113209997 hasConceptScore W2113209997C177148314 @default.
• W2113209997 hasConceptScore W2113209997C188087704 @default.
• W2113209997 hasConceptScore W2113209997C2524010 @default.
• W2113209997 hasConceptScore W2113209997C27158222 @default.

• next