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• W2113215524 startingPage "361" @default.
• W2113215524 abstract "Normal trophoblast function, including implantation, hormone production, and formation of the selectively permeable maternofetal barrier, is essential for the establishment and maintenance of the fetoplacental unit and proper fetal development. Maternal cytotoxicant exposure causes the destruction of these cells, especially the terminally differentiated syncytiotrophoblasts, and results in a myriad of poor pregnancy outcomes. These outcomes range from intrauterine growth retardation and malformation to spontaneous abortion or stillbirth. There is recent evidence that the metal-binding protein, metallothionein, is involved in the protection of human trophoblastic cells from heavy metal-induced and severe oxidative stress-induced apoptosis. Metallothionein, with its unique biochemical structure, can both bind essential metal ions, such as the transcription modulator zinc, and yet allow their ready displacement by toxic nonessential metal ions or damaging free radicals. These properties suggest that metallothionein may be responsible not only for sequestering the cytotoxic agents, but also for altering signal transduction in the affected cells. Here, we review several identified causes of adverse pregnancy outcomes (specifically, prenatal exposure to cigarette smoke and alcohol, gestational infection, and exposure to environmental contaminants), discuss the role of zinc in modulating the cellular response to these toxic insults, and then propose how metallothionein may function to mediate this protective response." @default.
• W2113215524 created "2016-06-24" @default.
• W2113215524 creator A5057499766 @default.
• W2113215524 creator A5090115592 @default.
• W2113215524 date "2004-12-01" @default.
• W2113215524 modified "2023-09-23" @default.
• W2113215524 title "Cytotoxicant-induced trophoblast dysfunction and abnormal pregnancy outcomes: Role of zinc and metallothionein" @default.
• W2113215524 cites W145109048 @default.
• W2113215524 cites W1531684593 @default.
• W2113215524 cites W15555732 @default.
• W2113215524 cites W1756010385 @default.
• W2113215524 cites W1855528635 @default.
• W2113215524 cites W1899550789 @default.
• W2113215524 cites W1911913279 @default.
• W2113215524 cites W1930588251 @default.
• W2113215524 cites W1943607432 @default.
• W2113215524 cites W1949591994 @default.
• W2113215524 cites W1964775097 @default.
• W2113215524 cites W1966090719 @default.
• W2113215524 cites W1966260518 @default.
• W2113215524 cites W1967602315 @default.
• W2113215524 cites W1969510769 @default.
• W2113215524 cites W1971332145 @default.
• W2113215524 cites W1972260601 @default.
• W2113215524 cites W1972556926 @default.
• W2113215524 cites W1975193879 @default.
• W2113215524 cites W1975230225 @default.
• W2113215524 cites W1975896097 @default.
• W2113215524 cites W1976872798 @default.
• W2113215524 cites W1982031557 @default.
• W2113215524 cites W1982140125 @default.
• W2113215524 cites W1984597733 @default.
• W2113215524 cites W1987046470 @default.
• W2113215524 cites W1987595762 @default.
• W2113215524 cites W1987774863 @default.
• W2113215524 cites W1991127027 @default.
• W2113215524 cites W1992392860 @default.
• W2113215524 cites W1996732248 @default.
• W2113215524 cites W1996980778 @default.
• W2113215524 cites W1999610370 @default.
• W2113215524 cites W2003718814 @default.
• W2113215524 cites W2004912053 @default.
• W2113215524 cites W2005180922 @default.
• W2113215524 cites W2008573133 @default.
• W2113215524 cites W2010347552 @default.
• W2113215524 cites W2015946435 @default.
• W2113215524 cites W2017501152 @default.
• W2113215524 cites W2017598440 @default.
• W2113215524 cites W2019379404 @default.
• W2113215524 cites W2020226114 @default.
• W2113215524 cites W2020802597 @default.
• W2113215524 cites W2022438517 @default.
• W2113215524 cites W2023089610 @default.
• W2113215524 cites W2023582210 @default.
• W2113215524 cites W2023704290 @default.
• W2113215524 cites W2024457154 @default.
• W2113215524 cites W2026852036 @default.
• W2113215524 cites W2029639276 @default.
• W2113215524 cites W2029932272 @default.
• W2113215524 cites W2031161936 @default.
• W2113215524 cites W2035919643 @default.
• W2113215524 cites W2043045196 @default.
• W2113215524 cites W2043513258 @default.
• W2113215524 cites W2044267161 @default.
• W2113215524 cites W2045658860 @default.
• W2113215524 cites W2046646032 @default.
• W2113215524 cites W2049698438 @default.
• W2113215524 cites W2049967634 @default.
• W2113215524 cites W2050386532 @default.
• W2113215524 cites W2051089000 @default.
• W2113215524 cites W2051730775 @default.
• W2113215524 cites W2051836136 @default.
• W2113215524 cites W2053449483 @default.
• W2113215524 cites W2054843429 @default.
• W2113215524 cites W2057226779 @default.
• W2113215524 cites W2058203708 @default.
• W2113215524 cites W2059888781 @default.
• W2113215524 cites W2061152334 @default.
• W2113215524 cites W2062352608 @default.
• W2113215524 cites W2063803756 @default.
• W2113215524 cites W2068028252 @default.
• W2113215524 cites W2068823390 @default.
• W2113215524 cites W2073869550 @default.
• W2113215524 cites W2075187399 @default.
• W2113215524 cites W2076092368 @default.
• W2113215524 cites W2078193113 @default.
• W2113215524 cites W2080164857 @default.
• W2113215524 cites W2084155274 @default.
• W2113215524 cites W2085885091 @default.
• W2113215524 cites W2086809297 @default.
• W2113215524 cites W2087009270 @default.
• W2113215524 cites W2088527624 @default.
• W2113215524 cites W2089920011 @default.
• W2113215524 cites W2090064924 @default.
• W2113215524 cites W2097650481 @default.
• W2113215524 cites W2097883014 @default.
• W2113215524 cites W2105767263 @default.
• W2113215524 cites W2110292482 @default.

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