Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113216488> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2113216488 endingPage "444" @default.
- W2113216488 startingPage "442" @default.
- W2113216488 abstract "The protective role of nitric oxide (NO) against hepatic ischemia-reperfusion (I/R) injury remains controversial. In this study we investigated the effect of tetrahydrobiopterin (BH4) on the survival of rats exposed to an hepatic I/R injury.The rats were subjected to 100 minutes of 70% hepatic ischemia 30 minutes after administration of BH4 or saline. A specific inducible NO synthase (iNOS) blocker, 1400W, was used to evaluate endogenous iNOS. NOS protein measured the histological appearance of the liver by Western blotting, and survival was evaluated after reperfusion.The 1-week survival rate was 60% among the BH4 group and 10% for the saline group. The serum ALT and bilirubin values in the BH4 group were significantly lower than the saline group. Histological examination of the liver revealed only a small necrotic area in the BH4 group as opposed to massive necrosis and cell infiltration in the saline group. Injection of 1400W significantly decreased the prolongation of survival produced by BH4.BH4 significantly improved the survival rate, the histological findings, and the liver function, thereby reducing liver failure. Western blotting showed a higher level of iNOS protein in the BH4 group than the saline group, 1400W suppressed this effect of BH4. Taken together, these observations suggest that NO derived from reactions driven by BH4-induced iNOS exerts a protective effect against reperfusion injury." @default.
- W2113216488 created "2016-06-24" @default.
- W2113216488 creator A5000856688 @default.
- W2113216488 creator A5015129597 @default.
- W2113216488 creator A5019200581 @default.
- W2113216488 creator A5020902533 @default.
- W2113216488 creator A5023396836 @default.
- W2113216488 creator A5031236297 @default.
- W2113216488 creator A5036838251 @default.
- W2113216488 creator A5058798362 @default.
- W2113216488 date "2005-01-01" @default.
- W2113216488 modified "2023-09-27" @default.
- W2113216488 title "Beneficial effect of tetrahydrobiopterin on the survival of rats exposed to hepatic ischemia-reperfusion injury" @default.
- W2113216488 cites W1237505467 @default.
- W2113216488 cites W1972089133 @default.
- W2113216488 cites W1986596262 @default.
- W2113216488 cites W1992242112 @default.
- W2113216488 cites W2117178669 @default.
- W2113216488 cites W2143796432 @default.
- W2113216488 cites W2150174968 @default.
- W2113216488 doi "https://doi.org/10.1016/j.transproceed.2004.12.051" @default.
- W2113216488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15808670" @default.
- W2113216488 hasPublicationYear "2005" @default.
- W2113216488 type Work @default.
- W2113216488 sameAs 2113216488 @default.
- W2113216488 citedByCount "12" @default.
- W2113216488 countsByYear W21132164882017 @default.
- W2113216488 countsByYear W21132164882022 @default.
- W2113216488 crossrefType "journal-article" @default.
- W2113216488 hasAuthorship W2113216488A5000856688 @default.
- W2113216488 hasAuthorship W2113216488A5015129597 @default.
- W2113216488 hasAuthorship W2113216488A5019200581 @default.
- W2113216488 hasAuthorship W2113216488A5020902533 @default.
- W2113216488 hasAuthorship W2113216488A5023396836 @default.
- W2113216488 hasAuthorship W2113216488A5031236297 @default.
- W2113216488 hasAuthorship W2113216488A5036838251 @default.
- W2113216488 hasAuthorship W2113216488A5058798362 @default.
- W2113216488 hasConcept C104317684 @default.
- W2113216488 hasConcept C126322002 @default.
- W2113216488 hasConcept C134018914 @default.
- W2113216488 hasConcept C142724271 @default.
- W2113216488 hasConcept C2776145790 @default.
- W2113216488 hasConcept C2777397205 @default.
- W2113216488 hasConcept C2777622882 @default.
- W2113216488 hasConcept C2780114680 @default.
- W2113216488 hasConcept C503630168 @default.
- W2113216488 hasConcept C519581460 @default.
- W2113216488 hasConcept C541997718 @default.
- W2113216488 hasConcept C55493867 @default.
- W2113216488 hasConcept C71924100 @default.
- W2113216488 hasConcept C85265743 @default.
- W2113216488 hasConcept C86803240 @default.
- W2113216488 hasConceptScore W2113216488C104317684 @default.
- W2113216488 hasConceptScore W2113216488C126322002 @default.
- W2113216488 hasConceptScore W2113216488C134018914 @default.
- W2113216488 hasConceptScore W2113216488C142724271 @default.
- W2113216488 hasConceptScore W2113216488C2776145790 @default.
- W2113216488 hasConceptScore W2113216488C2777397205 @default.
- W2113216488 hasConceptScore W2113216488C2777622882 @default.
- W2113216488 hasConceptScore W2113216488C2780114680 @default.
- W2113216488 hasConceptScore W2113216488C503630168 @default.
- W2113216488 hasConceptScore W2113216488C519581460 @default.
- W2113216488 hasConceptScore W2113216488C541997718 @default.
- W2113216488 hasConceptScore W2113216488C55493867 @default.
- W2113216488 hasConceptScore W2113216488C71924100 @default.
- W2113216488 hasConceptScore W2113216488C85265743 @default.
- W2113216488 hasConceptScore W2113216488C86803240 @default.
- W2113216488 hasIssue "1" @default.
- W2113216488 hasLocation W21132164881 @default.
- W2113216488 hasLocation W21132164882 @default.
- W2113216488 hasOpenAccess W2113216488 @default.
- W2113216488 hasPrimaryLocation W21132164881 @default.
- W2113216488 hasRelatedWork W1996343206 @default.
- W2113216488 hasRelatedWork W2062533504 @default.
- W2113216488 hasRelatedWork W2079776789 @default.
- W2113216488 hasRelatedWork W2090126574 @default.
- W2113216488 hasRelatedWork W2113216488 @default.
- W2113216488 hasRelatedWork W2319824260 @default.
- W2113216488 hasRelatedWork W2332886558 @default.
- W2113216488 hasRelatedWork W2353715290 @default.
- W2113216488 hasRelatedWork W2365533218 @default.
- W2113216488 hasRelatedWork W2389773480 @default.
- W2113216488 hasVolume "37" @default.
- W2113216488 isParatext "false" @default.
- W2113216488 isRetracted "false" @default.
- W2113216488 magId "2113216488" @default.
- W2113216488 workType "article" @default.