FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113219097> ?p ?o ?g. }

• W2113219097 endingPage "320" @default.
• W2113219097 startingPage "312" @default.
• W2113219097 abstract "Our previous study showed that small dosage of arginine vasopressin (AVP) had beneficial effect on shock by improving the shock-induced vascular hyporeactivity. But the mechanism is not clear. The objective of the present study is to investigate the role of V(1a) and V(2) receptors in AVP-mediated restoration of hemorrhage-induced vascular hyporesponsiveness and its relationship to protein kinase C (PKC), myosin light chain phosphatase (MLCP), and myosin light chain (MLC(20)) phosphorylation signal transduction pathway.We used isolated superior mesenteric artery (SMA) from hemorrhagic shock rats (40 mmHg for 2 hours) and 90 minutes hypoxia-treated vascular smooth muscle cell (VSMC) to study the effects of V(1a) and V(2) receptor inhibitors on AVP-mediated regulation of vascular reactivity and calcium sensitivity. Meanwhile the effects of AVP and V(1a) and V(2) receptor antagonists on the activity of MLCP and myosin light chain kinase (MLCK), and the phosphorylation of MLC(20), and the expression of PKC-alpha, delta, and epsilon isoforms were also studied.AVP significantly improved the reactivity of SMA to norepinephrine (NE) and Ca(2+) following hemorrhagic shock and increased the hypoxia-induced decrease of contractile response of VSMC to NE. The PKC-alpha and epsilon expression in particulate fractions of VSMC following hemorrhagic shock and hypoxia was also increased by treatment with AVP. V(1a) receptor inhibitor significantly antagonized these effects of AVP. AVP treatment resulted in a significant increase of MLC(20) phosphorylation in SMA and a significant decrease of MLCP activity in VSMC, which was also inhibited by V(1a) receptor inhibitor.V(1a) receptor, not V(2) receptor, played an important role in AVP-mediated regulation of vascular reactivity and calcium sensitivity following hemorrhagic shock. The mechanism is mainly through PKC-MLCP-MLC(20) phosphorylation calcium sensitivity pathway." @default.
• W2113219097 created "2016-06-24" @default.
• W2113219097 creator A5017069269 @default.
• W2113219097 creator A5017541508 @default.
• W2113219097 creator A5031335804 @default.
• W2113219097 creator A5045406516 @default.
• W2113219097 creator A5055987578 @default.
• W2113219097 creator A5091020799 @default.
• W2113219097 date "2010-06-01" @default.
• W2113219097 modified "2023-09-28" @default.
• W2113219097 title "Role of V1a Receptor in AVP-Induced Restoration of Vascular Hyporeactivity and Its Relationship to MLCP-MLC20 Phosphorylation Pathway" @default.
• W2113219097 cites W1582375112 @default.
• W2113219097 cites W1597787921 @default.
• W2113219097 cites W1977512348 @default.
• W2113219097 cites W1995716177 @default.
• W2113219097 cites W2000161513 @default.
• W2113219097 cites W2000410859 @default.
• W2113219097 cites W2006830036 @default.
• W2113219097 cites W2007513694 @default.
• W2113219097 cites W2018505115 @default.
• W2113219097 cites W2020547149 @default.
• W2113219097 cites W2029513164 @default.
• W2113219097 cites W2061481722 @default.
• W2113219097 cites W2081264354 @default.
• W2113219097 cites W2086524338 @default.
• W2113219097 cites W2092576934 @default.
• W2113219097 cites W2094038819 @default.
• W2113219097 cites W2100837269 @default.
• W2113219097 cites W2104793237 @default.
• W2113219097 cites W2108153775 @default.
• W2113219097 cites W2113316512 @default.
• W2113219097 cites W2114555592 @default.
• W2113219097 cites W2123328070 @default.
• W2113219097 cites W2123781391 @default.
• W2113219097 cites W2145797195 @default.
• W2113219097 cites W2153283433 @default.
• W2113219097 cites W2165073682 @default.
• W2113219097 doi "https://doi.org/10.1016/j.jss.2009.01.005" @default.
• W2113219097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19577256" @default.
• W2113219097 hasPublicationYear "2010" @default.
• W2113219097 type Work @default.
• W2113219097 sameAs 2113219097 @default.
• W2113219097 citedByCount "25" @default.
• W2113219097 countsByYear W21132190972012 @default.
• W2113219097 countsByYear W21132190972013 @default.
• W2113219097 countsByYear W21132190972014 @default.
• W2113219097 countsByYear W21132190972015 @default.
• W2113219097 countsByYear W21132190972016 @default.
• W2113219097 countsByYear W21132190972017 @default.
• W2113219097 countsByYear W21132190972019 @default.
• W2113219097 countsByYear W21132190972020 @default.
• W2113219097 countsByYear W21132190972021 @default.
• W2113219097 countsByYear W21132190972022 @default.
• W2113219097 crossrefType "journal-article" @default.
• W2113219097 hasAuthorship W2113219097A5017069269 @default.
• W2113219097 hasAuthorship W2113219097A5017541508 @default.
• W2113219097 hasAuthorship W2113219097A5031335804 @default.
• W2113219097 hasAuthorship W2113219097A5045406516 @default.
• W2113219097 hasAuthorship W2113219097A5055987578 @default.
• W2113219097 hasAuthorship W2113219097A5091020799 @default.
• W2113219097 hasConcept C11960822 @default.
• W2113219097 hasConcept C126322002 @default.
• W2113219097 hasConcept C134018914 @default.
• W2113219097 hasConcept C170493617 @default.
• W2113219097 hasConcept C195794163 @default.
• W2113219097 hasConcept C2776370428 @default.
• W2113219097 hasConcept C2779395532 @default.
• W2113219097 hasConcept C2779938346 @default.
• W2113219097 hasConcept C2992686903 @default.
• W2113219097 hasConcept C71924100 @default.
• W2113219097 hasConcept C8035138 @default.
• W2113219097 hasConcept C86803240 @default.
• W2113219097 hasConcept C95444343 @default.
• W2113219097 hasConceptScore W2113219097C11960822 @default.
• W2113219097 hasConceptScore W2113219097C126322002 @default.
• W2113219097 hasConceptScore W2113219097C134018914 @default.
• W2113219097 hasConceptScore W2113219097C170493617 @default.
• W2113219097 hasConceptScore W2113219097C195794163 @default.
• W2113219097 hasConceptScore W2113219097C2776370428 @default.
• W2113219097 hasConceptScore W2113219097C2779395532 @default.
• W2113219097 hasConceptScore W2113219097C2779938346 @default.
• W2113219097 hasConceptScore W2113219097C2992686903 @default.
• W2113219097 hasConceptScore W2113219097C71924100 @default.
• W2113219097 hasConceptScore W2113219097C8035138 @default.
• W2113219097 hasConceptScore W2113219097C86803240 @default.
• W2113219097 hasConceptScore W2113219097C95444343 @default.
• W2113219097 hasIssue "2" @default.
• W2113219097 hasLocation W21132190971 @default.
• W2113219097 hasLocation W21132190972 @default.
• W2113219097 hasOpenAccess W2113219097 @default.
• W2113219097 hasPrimaryLocation W21132190971 @default.
• W2113219097 hasRelatedWork W1964293580 @default.
• W2113219097 hasRelatedWork W1996846474 @default.
• W2113219097 hasRelatedWork W2040514438 @default.
• W2113219097 hasRelatedWork W2044402316 @default.
• W2113219097 hasRelatedWork W2101353144 @default.
• W2113219097 hasRelatedWork W2124380794 @default.
• W2113219097 hasRelatedWork W2129896811 @default.

• next