Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113219230> ?p ?o ?g. }
- W2113219230 endingPage "662" @default.
- W2113219230 startingPage "653" @default.
- W2113219230 abstract "Apathy, defined as a primary deficit in motivation and manifested by the simultaneous diminution in the cognitive and emotional concomitants of goal-directed behavior, is a common and debilitating non-motor symptom of Parkinson's disease (PD). Despite the high prevalence and clinical significance of apathy, little is known about its pathophysiology, and in particular how apathy relates to alterations in the neural circuitry underpinning the cognitive and emotional components of goal-directed behavior. Here, we examined the neural coding of reward cues in patients with PD, with or without clinically significant levels of apathy, during performance of a spatial search task during H2 15O PET (positron emission tomography) functional neuroimaging. By manipulating search outcome (money reward vs valueless token), while keeping the actions of the participants constant, we examined the influence of apathy on the neural coding of money reward cues. We found that apathy was associated with a blunted response to money in the ventromedial prefrontal cortex, amygdala, striatum, and midbrain, all part of a distributed neural circuit integral to the representation of the reward value of stimuli and actions, and the influence of reward cues on behavior. Disruption of this circuitry potentially underpins the expression of the various manifestations of apathy in PD, including reduced cognitive, emotional, and behavioral facets of goal-directed behavior." @default.
- W2113219230 created "2016-06-24" @default.
- W2113219230 creator A5001621228 @default.
- W2113219230 creator A5045336469 @default.
- W2113219230 creator A5086392680 @default.
- W2113219230 date "2011-10-01" @default.
- W2113219230 modified "2023-09-27" @default.
- W2113219230 title "Apathy blunts neural response to money in Parkinson's disease" @default.
- W2113219230 cites W1556623372 @default.
- W2113219230 cites W1575101351 @default.
- W2113219230 cites W1974266613 @default.
- W2113219230 cites W1983230739 @default.
- W2113219230 cites W1989615119 @default.
- W2113219230 cites W1992562869 @default.
- W2113219230 cites W1997659839 @default.
- W2113219230 cites W2001948633 @default.
- W2113219230 cites W2002961865 @default.
- W2113219230 cites W2003398171 @default.
- W2113219230 cites W2005962945 @default.
- W2113219230 cites W2006412233 @default.
- W2113219230 cites W2008145253 @default.
- W2113219230 cites W2014025757 @default.
- W2113219230 cites W2018353688 @default.
- W2113219230 cites W2019778340 @default.
- W2113219230 cites W2020628123 @default.
- W2113219230 cites W2023785308 @default.
- W2113219230 cites W2025866298 @default.
- W2113219230 cites W2027368063 @default.
- W2113219230 cites W2036883721 @default.
- W2113219230 cites W2037643842 @default.
- W2113219230 cites W2047620643 @default.
- W2113219230 cites W2054184505 @default.
- W2113219230 cites W2054368817 @default.
- W2113219230 cites W2056225668 @default.
- W2113219230 cites W2056448794 @default.
- W2113219230 cites W2056765716 @default.
- W2113219230 cites W2057001461 @default.
- W2113219230 cites W2057657406 @default.
- W2113219230 cites W2057778345 @default.
- W2113219230 cites W2058046532 @default.
- W2113219230 cites W2060476465 @default.
- W2113219230 cites W2062391269 @default.
- W2113219230 cites W2067441472 @default.
- W2113219230 cites W2070182265 @default.
- W2113219230 cites W2070972521 @default.
- W2113219230 cites W2071294744 @default.
- W2113219230 cites W2076256116 @default.
- W2113219230 cites W2078045231 @default.
- W2113219230 cites W2080839667 @default.
- W2113219230 cites W2082402452 @default.
- W2113219230 cites W2085647841 @default.
- W2113219230 cites W2085971650 @default.
- W2113219230 cites W2088135927 @default.
- W2113219230 cites W2088475596 @default.
- W2113219230 cites W2098354188 @default.
- W2113219230 cites W2100991928 @default.
- W2113219230 cites W2102875030 @default.
- W2113219230 cites W2103315959 @default.
- W2113219230 cites W2110345880 @default.
- W2113219230 cites W2111107077 @default.
- W2113219230 cites W2114278153 @default.
- W2113219230 cites W2116649573 @default.
- W2113219230 cites W2120803928 @default.
- W2113219230 cites W2121291149 @default.
- W2113219230 cites W2124726460 @default.
- W2113219230 cites W2128472904 @default.
- W2113219230 cites W2131325619 @default.
- W2113219230 cites W2131402502 @default.
- W2113219230 cites W2133077504 @default.
- W2113219230 cites W2135556239 @default.
- W2113219230 cites W2136347166 @default.
- W2113219230 cites W2136519562 @default.
- W2113219230 cites W2140066975 @default.
- W2113219230 cites W2145286440 @default.
- W2113219230 cites W2145777576 @default.
- W2113219230 cites W2147385857 @default.
- W2113219230 cites W2149695930 @default.
- W2113219230 cites W2150409513 @default.
- W2113219230 cites W2150594880 @default.
- W2113219230 cites W2151865900 @default.
- W2113219230 cites W2152316935 @default.
- W2113219230 cites W2155225843 @default.
- W2113219230 cites W2161301235 @default.
- W2113219230 cites W2163805252 @default.
- W2113219230 cites W2166211493 @default.
- W2113219230 cites W2168132298 @default.
- W2113219230 cites W2171031585 @default.
- W2113219230 cites W2276751657 @default.
- W2113219230 cites W2330962946 @default.
- W2113219230 cites W4238669448 @default.
- W2113219230 cites W4251407708 @default.
- W2113219230 cites W4317926736 @default.
- W2113219230 cites W74099017 @default.
- W2113219230 doi "https://doi.org/10.1080/17470919.2011.556821" @default.
- W2113219230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21400357" @default.
- W2113219230 hasPublicationYear "2011" @default.
- W2113219230 type Work @default.
- W2113219230 sameAs 2113219230 @default.