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- W2113219792 abstract "To review recent clinical pharmacokinetic and pharmacodynamic data to optimize dosing regimens for polymyxin B and colistin for treatment of infections due to A. baumannii.A literature search was performed using the search terms Acinetobacter, polymyxin, colistin, polymyxin B on MEDLINE. Additional references were identified from the resulting citations.Increasing the dose of polymyxin B or colistin and using either in combination with other antibiotic agents demonstrates improved antimicrobial activity against Acinetobacter spp. Polymyxin B, unlike colistin, is available as an active drug and appears to be relatively unaffected by renal function. This is advantageous both for patients with renal impairment and for those with intact renal function. Achieving therapeutic serum concentrations of colistin may be difficult for those with intact renal function due to rapid clearance of the prodrug, colistimethate sodium (CMS). Clinical data are still lacking for polymyxin B, and it remains to be seen whether advantages demonstrated in PK/PD analyses will persist in the larger scale of patient care and safety.The use of higher doses of either colistin or polymyxin B, as well as combination with other antibiotics, may prevent emerging resistance and preserve the activity of polymyxins against A. baumannii." @default.
- W2113219792 created "2016-06-24" @default.
- W2113219792 creator A5049621560 @default.
- W2113219792 creator A5081146250 @default.
- W2113219792 creator A5088761587 @default.
- W2113219792 date "2015-01-01" @default.
- W2113219792 modified "2023-10-18" @default.
- W2113219792 title "An Update on the arsenal for multidrug-resistant Acinetobacter infections: Polymyxin antibiotics" @default.
- W2113219792 cites W1602597014 @default.
- W2113219792 cites W1773649478 @default.
- W2113219792 cites W1920812949 @default.
- W2113219792 cites W1966419284 @default.
- W2113219792 cites W1967253673 @default.
- W2113219792 cites W1971252925 @default.
- W2113219792 cites W1985567596 @default.
- W2113219792 cites W1988549330 @default.
- W2113219792 cites W1993397663 @default.
- W2113219792 cites W2000167748 @default.
- W2113219792 cites W2002423253 @default.
- W2113219792 cites W2010825345 @default.
- W2113219792 cites W2012828336 @default.
- W2113219792 cites W2026698060 @default.
- W2113219792 cites W2027813901 @default.
- W2113219792 cites W2043209435 @default.
- W2113219792 cites W2045228130 @default.
- W2113219792 cites W2046993354 @default.
- W2113219792 cites W2058603740 @default.
- W2113219792 cites W2058835846 @default.
- W2113219792 cites W2062595051 @default.
- W2113219792 cites W2063448964 @default.
- W2113219792 cites W2070752040 @default.
- W2113219792 cites W2071812276 @default.
- W2113219792 cites W2074644957 @default.
- W2113219792 cites W2084542918 @default.
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- W2113219792 cites W2095325172 @default.
- W2113219792 cites W2096864263 @default.
- W2113219792 cites W2098161344 @default.
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- W2113219792 cites W2116660179 @default.
- W2113219792 cites W2118734761 @default.
- W2113219792 cites W2118975078 @default.
- W2113219792 cites W2119596752 @default.
- W2113219792 cites W2120229303 @default.
- W2113219792 cites W2120292666 @default.
- W2113219792 cites W2123353572 @default.
- W2113219792 cites W2123800213 @default.
- W2113219792 cites W2124996394 @default.
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- W2113219792 cites W2134377638 @default.
- W2113219792 cites W2134744238 @default.
- W2113219792 cites W2134747733 @default.
- W2113219792 cites W2135373868 @default.
- W2113219792 cites W2142212618 @default.
- W2113219792 cites W2143794235 @default.
- W2113219792 cites W2144931844 @default.
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- W2113219792 cites W2159622766 @default.
- W2113219792 cites W2160900386 @default.
- W2113219792 cites W2161069049 @default.
- W2113219792 cites W2162107182 @default.
- W2113219792 cites W2162268639 @default.
- W2113219792 cites W2162661622 @default.
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- W2113219792 cites W2164470790 @default.
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- W2113219792 cites W2167117360 @default.
- W2113219792 cites W2168223549 @default.
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- W2113219792 cites W2222055922 @default.
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- W2113219792 doi "https://doi.org/10.1016/j.ijid.2014.10.014" @default.
- W2113219792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25461655" @default.
- W2113219792 hasPublicationYear "2015" @default.
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