FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113224591> ?p ?o ?g. }

• W2113224591 endingPage "191" @default.
• W2113224591 startingPage "179" @default.
• W2113224591 abstract "The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than cholesterol (IC50 values of 8 mu M and 142 mu M for 27-hydroxycholesterol and cholesterol, respectively) when the sterols were delivered to cells from 2-hydroxypropyl-beta-cyclodextrin (beta-CD)-solubilized solutions. Cyclosporin, an immunosuppressant which has been shown to inhibit the 27-hydroxylation of sterols, was used to assess whether the formation of endogenous 27-hydroxycholesterol was required for the cholesterol-induced suppression of LDL receptor activity. Cyclosporin dose-dependently inhibited the 27-hydroxylation of cholesterol by HepG2 mitochondria (Ki = 0.25 mu M) and HepG2 cell cultures (IC50 = 1 mu M). At 1 mu M, cyclosporin had no effect on LDL receptor activity, and did not prevent the suppression of LDL receptor activity caused by: 1) the addition of beta-CD-solubilized cholesterol, 2) the receptor-mediated uptake of beta-VLDL, or 3) the inhibition of cholesterol esterification. In contrast, 10 mu M cyclosporin was found to inhibit the esterification of cholesterol and to increase the cellular level of free cholesterol resulting in suppression of LDL receptor activity. These results suggest that if mitochondrial sterol 27-hydroxylase plays a role in the regulation of LDL receptor activity, it is not through the formation of potent regulatory oxysterols, but through its effects on the availability and/or size of the free cholesterol pool regulating LDL receptor activity." @default.
• W2113224591 created "2016-06-24" @default.
• W2113224591 creator A5010453470 @default.
• W2113224591 creator A5037619967 @default.
• W2113224591 creator A5043108668 @default.
• W2113224591 creator A5088514884 @default.
• W2113224591 date "1996-01-01" @default.
• W2113224591 modified "2023-10-12" @default.
• W2113224591 title "Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells." @default.
• W2113224591 cites W1482432683 @default.
• W2113224591 cites W1484508453 @default.
• W2113224591 cites W1494702528 @default.
• W2113224591 cites W1496814847 @default.
• W2113224591 cites W1509346516 @default.
• W2113224591 cites W1522459970 @default.
• W2113224591 cites W1550638578 @default.
• W2113224591 cites W1555538371 @default.
• W2113224591 cites W1557519226 @default.
• W2113224591 cites W1575051768 @default.
• W2113224591 cites W1597768999 @default.
• W2113224591 cites W1664014775 @default.
• W2113224591 cites W1902852842 @default.
• W2113224591 cites W1962029512 @default.
• W2113224591 cites W1968317051 @default.
• W2113224591 cites W1979846275 @default.
• W2113224591 cites W1980419912 @default.
• W2113224591 cites W1986849641 @default.
• W2113224591 cites W1997167574 @default.
• W2113224591 cites W1998281943 @default.
• W2113224591 cites W2004152365 @default.
• W2113224591 cites W2012414997 @default.
• W2113224591 cites W2013031778 @default.
• W2113224591 cites W2021632088 @default.
• W2113224591 cites W2026393575 @default.
• W2113224591 cites W2026640792 @default.
• W2113224591 cites W2040641918 @default.
• W2113224591 cites W2049018326 @default.
• W2113224591 cites W2053533328 @default.
• W2113224591 cites W2071124826 @default.
• W2113224591 cites W2072958806 @default.
• W2113224591 cites W2084744450 @default.
• W2113224591 cites W2086831301 @default.
• W2113224591 cites W2091914091 @default.
• W2113224591 cites W2101690193 @default.
• W2113224591 cites W2118535904 @default.
• W2113224591 cites W2132332858 @default.
• W2113224591 cites W2136685915 @default.
• W2113224591 cites W2146768805 @default.
• W2113224591 cites W2152945072 @default.
• W2113224591 cites W2154133061 @default.
• W2113224591 cites W2156799866 @default.
• W2113224591 cites W2158259814 @default.
• W2113224591 cites W2171904028 @default.
• W2113224591 cites W2173653136 @default.
• W2113224591 cites W2188171721 @default.
• W2113224591 cites W2328429989 @default.
• W2113224591 cites W2343549517 @default.
• W2113224591 cites W2345918639 @default.
• W2113224591 cites W2396267007 @default.
• W2113224591 cites W2397797320 @default.
• W2113224591 cites W2403690283 @default.
• W2113224591 cites W2413579708 @default.
• W2113224591 cites W4232534952 @default.
• W2113224591 doi "https://doi.org/10.1016/s0022-2275(20)37646-x" @default.
• W2113224591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8820113" @default.
• W2113224591 hasPublicationYear "1996" @default.
• W2113224591 type Work @default.
• W2113224591 sameAs 2113224591 @default.
• W2113224591 citedByCount "47" @default.
• W2113224591 countsByYear W21132245912012 @default.
• W2113224591 countsByYear W21132245912013 @default.
• W2113224591 countsByYear W21132245912014 @default.
• W2113224591 countsByYear W21132245912015 @default.
• W2113224591 countsByYear W21132245912016 @default.
• W2113224591 countsByYear W21132245912019 @default.
• W2113224591 countsByYear W21132245912020 @default.
• W2113224591 countsByYear W21132245912021 @default.
• W2113224591 countsByYear W21132245912023 @default.
• W2113224591 crossrefType "journal-article" @default.
• W2113224591 hasAuthorship W2113224591A5010453470 @default.
• W2113224591 hasAuthorship W2113224591A5037619967 @default.
• W2113224591 hasAuthorship W2113224591A5043108668 @default.
• W2113224591 hasAuthorship W2113224591A5088514884 @default.
• W2113224591 hasBestOaLocation W21132245911 @default.
• W2113224591 hasConcept C126322002 @default.
• W2113224591 hasConcept C181199279 @default.
• W2113224591 hasConcept C185592680 @default.
• W2113224591 hasConcept C2778163477 @default.
• W2113224591 hasConcept C2781109383 @default.
• W2113224591 hasConcept C55493867 @default.
• W2113224591 hasConcept C71924100 @default.
• W2113224591 hasConcept C86803240 @default.
• W2113224591 hasConcept C98274493 @default.
• W2113224591 hasConceptScore W2113224591C126322002 @default.
• W2113224591 hasConceptScore W2113224591C181199279 @default.
• W2113224591 hasConceptScore W2113224591C185592680 @default.
• W2113224591 hasConceptScore W2113224591C2778163477 @default.
• W2113224591 hasConceptScore W2113224591C2781109383 @default.

• next