Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113226502> ?p ?o ?g. }
- W2113226502 endingPage "1765" @default.
- W2113226502 startingPage "1756" @default.
- W2113226502 abstract "A burst of action potentials in hippocampal neurons is followed by a slow afterhyperpolarization (sAHP) that serves to limit subsequent firing. A reduction in the sAHP accompanies acquisition of several types of learning, whereas increases in the sAHP are correlated with cognitive impairment. The present study demonstrates in vitro that activity-dependent bidirectional plasticity of the sAHP does not require synaptic activation, and depends on the pattern of action potential firing. Whole-cell current-clamp recordings from CA1 pyramidal neurons in hippocampal slices from young rats (postnatal days 14-24) were performed in blockers of synaptic transmission. The sAHP was evoked by action potential firing at gamma-related (50 Hz, gamma-AHP) or theta frequencies (5 Hz, theta-AHP), two firing frequencies implicated in attention and memory. Interestingly, when the gamma-AHP and theta-AHP were evoked in the same cell, a gradual potentiation of the gamma-AHP (186 ± 31%) was observed that was blocked using Ca(2+) channel blockers nimodipine (10 μm) or ω-conotoxin MVIIC (1 μm). In experiments that exclusively evoked the sAHP with 50 Hz firing, the gamma-AHP was similarly potentiated (198 ± 44%). However, theta-burst firing pattern alone resulted in a decrease (65 ± 19%) of the sAHP. In these experiments, application of the h-channel blocker ZD7288 (25 μm) selectively prevented enhancement of the gamma-AHP. These data demonstrate that induction requirements for bidirectional AHP plasticity depend on the pattern of action potential firing, and result from distinct mechanisms. The identification of novel mechanisms underlying AHP plasticity in vitro provides additional insight into the dynamic processes that may regulate neuronal excitability during learning in vivo." @default.
- W2113226502 created "2016-06-24" @default.
- W2113226502 creator A5073164917 @default.
- W2113226502 date "2011-11-20" @default.
- W2113226502 modified "2023-10-09" @default.
- W2113226502 title "Bidirectional pattern-specific plasticity of the slow afterhyperpolarization in rats: role for high-voltage activated Ca2+ channels and Ih" @default.
- W2113226502 cites W1568903867 @default.
- W2113226502 cites W1570612396 @default.
- W2113226502 cites W1900667823 @default.
- W2113226502 cites W1953977319 @default.
- W2113226502 cites W1955958386 @default.
- W2113226502 cites W1969727132 @default.
- W2113226502 cites W1970542265 @default.
- W2113226502 cites W1970747055 @default.
- W2113226502 cites W1972628506 @default.
- W2113226502 cites W1979411530 @default.
- W2113226502 cites W1980833896 @default.
- W2113226502 cites W1987369275 @default.
- W2113226502 cites W1987593629 @default.
- W2113226502 cites W1989712467 @default.
- W2113226502 cites W1991904093 @default.
- W2113226502 cites W2000562722 @default.
- W2113226502 cites W2001851169 @default.
- W2113226502 cites W2002478276 @default.
- W2113226502 cites W2003922862 @default.
- W2113226502 cites W2025206376 @default.
- W2113226502 cites W2031822869 @default.
- W2113226502 cites W2032006598 @default.
- W2113226502 cites W2032193977 @default.
- W2113226502 cites W2035845442 @default.
- W2113226502 cites W2037008204 @default.
- W2113226502 cites W2048528277 @default.
- W2113226502 cites W2048685634 @default.
- W2113226502 cites W2050658976 @default.
- W2113226502 cites W2052103464 @default.
- W2113226502 cites W2055568369 @default.
- W2113226502 cites W2057717270 @default.
- W2113226502 cites W2057888375 @default.
- W2113226502 cites W2058491602 @default.
- W2113226502 cites W2061830467 @default.
- W2113226502 cites W2065067025 @default.
- W2113226502 cites W2068235536 @default.
- W2113226502 cites W2070212214 @default.
- W2113226502 cites W2074004398 @default.
- W2113226502 cites W2077624336 @default.
- W2113226502 cites W2078156825 @default.
- W2113226502 cites W2078665021 @default.
- W2113226502 cites W2084385675 @default.
- W2113226502 cites W2084890935 @default.
- W2113226502 cites W2092346891 @default.
- W2113226502 cites W2093446419 @default.
- W2113226502 cites W2096081604 @default.
- W2113226502 cites W2103156942 @default.
- W2113226502 cites W2105148858 @default.
- W2113226502 cites W2105735040 @default.
- W2113226502 cites W2106548361 @default.
- W2113226502 cites W2109545010 @default.
- W2113226502 cites W2112196515 @default.
- W2113226502 cites W2114488287 @default.
- W2113226502 cites W2118974644 @default.
- W2113226502 cites W2120349779 @default.
- W2113226502 cites W2123849072 @default.
- W2113226502 cites W2125737923 @default.
- W2113226502 cites W2127236564 @default.
- W2113226502 cites W2130139021 @default.
- W2113226502 cites W2131141854 @default.
- W2113226502 cites W2132785335 @default.
- W2113226502 cites W2136040261 @default.
- W2113226502 cites W2152032577 @default.
- W2113226502 cites W2160559898 @default.
- W2113226502 cites W2162634566 @default.
- W2113226502 cites W2163301650 @default.
- W2113226502 cites W2171668474 @default.
- W2113226502 cites W2173794755 @default.
- W2113226502 cites W2194182520 @default.
- W2113226502 cites W2261590581 @default.
- W2113226502 cites W2396331417 @default.
- W2113226502 cites W2406582924 @default.
- W2113226502 cites W2410542938 @default.
- W2113226502 cites W2417468215 @default.
- W2113226502 cites W2467847652 @default.
- W2113226502 cites W2472213757 @default.
- W2113226502 cites W299532404 @default.
- W2113226502 cites W4241263431 @default.
- W2113226502 cites W4243516215 @default.
- W2113226502 doi "https://doi.org/10.1111/j.1460-9568.2011.07899.x" @default.
- W2113226502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3228416" @default.
- W2113226502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22098477" @default.
- W2113226502 hasPublicationYear "2011" @default.
- W2113226502 type Work @default.
- W2113226502 sameAs 2113226502 @default.
- W2113226502 citedByCount "19" @default.
- W2113226502 countsByYear W21132265022014 @default.
- W2113226502 countsByYear W21132265022015 @default.
- W2113226502 countsByYear W21132265022016 @default.
- W2113226502 countsByYear W21132265022017 @default.
- W2113226502 countsByYear W21132265022018 @default.
- W2113226502 countsByYear W21132265022019 @default.