FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113227373> ?p ?o ?g. }

• W2113227373 endingPage "771" @default.
• W2113227373 startingPage "764" @default.
• W2113227373 abstract "β,β-Dimethylacrylshikonin is one of the most abundant naphthoquinones in the root extracts of Lithospermum erythrorhizon Sieb. et Zucc. (Boraginaceae), which have been reported to have antitumor effects. This study evaluated the antiproliferative activity of β,β-dimethylacrylshikonin on human hepatocellular carcinoma (HCC) cells both in vitro and in vivo. In vitro, the MTT assay showed that β,β-dimethylacrylshikonin inhibited the proliferation of SMMC-7721 cells in both dose- and time-dependent manners with its 50% inhibitory concentration (IC50) at 48 h being 15.01 ± 0.76 µg/mL. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) and Hoechst staining detected the characteristics of cell apoptosis in β,β-dimethylacrylshikonin-treated cells and the apoptotic rates of treated groups were increased in a dose-dependent manner. Flow cytometric analysis revealed that β,β-dimethylacrylshikonin could block the cell cycle arrest at G2 phase. Furthermore, β,β-dimethylacrylshikonin down-regulated the mRNA and protein expression of Bcl-2 but up-regulated that of Bax. The cleaved caspase-3 protein was also detected in treated cells. The experiment in vivo showed that β,β-dimethylacrylshikonin significantly suppressed the growth of H22 transplantable hepatoma, and induced the activation of caspase-3 determined by immunohistochemistry. The results indicate that β,β-dimethylacrylshikonin has significant antitumor effects on hepatocellular carcinoma both in vitro and in vivo. Copyright © 2011 John Wiley & Sons, Ltd." @default.
• W2113227373 created "2016-06-24" @default.
• W2113227373 creator A5018263002 @default.
• W2113227373 creator A5019145813 @default.
• W2113227373 creator A5022913770 @default.
• W2113227373 creator A5041848190 @default.
• W2113227373 creator A5045375528 @default.
• W2113227373 creator A5047028881 @default.
• W2113227373 creator A5053727718 @default.
• W2113227373 creator A5062823224 @default.
• W2113227373 creator A5075282134 @default.
• W2113227373 creator A5081730656 @default.
• W2113227373 date "2011-11-23" @default.
• W2113227373 modified "2023-09-27" @default.
• W2113227373 title "Inhibitory Effects of β,β-Dimethylacrylshikonin on Hepatocellular Carcinoma <i>In Vitro</i> and <i>In Vivo</i>" @default.
• W2113227373 cites W1968329380 @default.
• W2113227373 cites W1975352836 @default.
• W2113227373 cites W2001177851 @default.
• W2113227373 cites W2007057690 @default.
• W2113227373 cites W2016034696 @default.
• W2113227373 cites W2026211921 @default.
• W2113227373 cites W2030356635 @default.
• W2113227373 cites W2047389902 @default.
• W2113227373 cites W2064251865 @default.
• W2113227373 cites W2069625630 @default.
• W2113227373 cites W2072078413 @default.
• W2113227373 cites W2072588646 @default.
• W2113227373 cites W2079931546 @default.
• W2113227373 cites W2088282111 @default.
• W2113227373 cites W2095326001 @default.
• W2113227373 cites W2102912467 @default.
• W2113227373 cites W2105222502 @default.
• W2113227373 cites W2121823387 @default.
• W2113227373 cites W2132101256 @default.
• W2113227373 cites W2143089914 @default.
• W2113227373 cites W2165805342 @default.
• W2113227373 cites W2750896950 @default.
• W2113227373 doi "https://doi.org/10.1002/ptr.3623" @default.
• W2113227373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22109831" @default.
• W2113227373 hasPublicationYear "2011" @default.
• W2113227373 type Work @default.
• W2113227373 sameAs 2113227373 @default.
• W2113227373 citedByCount "19" @default.
• W2113227373 countsByYear W21132273732012 @default.
• W2113227373 countsByYear W21132273732013 @default.
• W2113227373 countsByYear W21132273732014 @default.
• W2113227373 countsByYear W21132273732016 @default.
• W2113227373 countsByYear W21132273732017 @default.
• W2113227373 countsByYear W21132273732018 @default.
• W2113227373 countsByYear W21132273732020 @default.
• W2113227373 countsByYear W21132273732021 @default.
• W2113227373 countsByYear W21132273732022 @default.
• W2113227373 countsByYear W21132273732023 @default.
• W2113227373 crossrefType "journal-article" @default.
• W2113227373 hasAuthorship W2113227373A5018263002 @default.
• W2113227373 hasAuthorship W2113227373A5019145813 @default.
• W2113227373 hasAuthorship W2113227373A5022913770 @default.
• W2113227373 hasAuthorship W2113227373A5041848190 @default.
• W2113227373 hasAuthorship W2113227373A5045375528 @default.
• W2113227373 hasAuthorship W2113227373A5047028881 @default.
• W2113227373 hasAuthorship W2113227373A5053727718 @default.
• W2113227373 hasAuthorship W2113227373A5062823224 @default.
• W2113227373 hasAuthorship W2113227373A5075282134 @default.
• W2113227373 hasAuthorship W2113227373A5081730656 @default.
• W2113227373 hasConcept C150903083 @default.
• W2113227373 hasConcept C153911025 @default.
• W2113227373 hasConcept C154113507 @default.
• W2113227373 hasConcept C185592680 @default.
• W2113227373 hasConcept C190283241 @default.
• W2113227373 hasConcept C196795494 @default.
• W2113227373 hasConcept C202751555 @default.
• W2113227373 hasConcept C207001950 @default.
• W2113227373 hasConcept C2775948271 @default.
• W2113227373 hasConcept C2778019345 @default.
• W2113227373 hasConcept C2780783641 @default.
• W2113227373 hasConcept C29537977 @default.
• W2113227373 hasConcept C502942594 @default.
• W2113227373 hasConcept C55493867 @default.
• W2113227373 hasConcept C59822182 @default.
• W2113227373 hasConcept C62112901 @default.
• W2113227373 hasConcept C86803240 @default.
• W2113227373 hasConceptScore W2113227373C150903083 @default.
• W2113227373 hasConceptScore W2113227373C153911025 @default.
• W2113227373 hasConceptScore W2113227373C154113507 @default.
• W2113227373 hasConceptScore W2113227373C185592680 @default.
• W2113227373 hasConceptScore W2113227373C190283241 @default.
• W2113227373 hasConceptScore W2113227373C196795494 @default.
• W2113227373 hasConceptScore W2113227373C202751555 @default.
• W2113227373 hasConceptScore W2113227373C207001950 @default.
• W2113227373 hasConceptScore W2113227373C2775948271 @default.
• W2113227373 hasConceptScore W2113227373C2778019345 @default.
• W2113227373 hasConceptScore W2113227373C2780783641 @default.
• W2113227373 hasConceptScore W2113227373C29537977 @default.
• W2113227373 hasConceptScore W2113227373C502942594 @default.
• W2113227373 hasConceptScore W2113227373C55493867 @default.
• W2113227373 hasConceptScore W2113227373C59822182 @default.
• W2113227373 hasConceptScore W2113227373C62112901 @default.
• W2113227373 hasConceptScore W2113227373C86803240 @default.

• next