Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113229059> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2113229059 endingPage "39" @default.
- W2113229059 startingPage "35" @default.
- W2113229059 abstract "Problem statement: Dihydrofolate Reductase (DHFR) and Thymidylate Synthase (TS) exist as bifunctional enzymes coded into unique polypeptide chain in protozoans. Bifunctional DHFR-TS is associated with an increase in the enzymatic activity by channeling the substrate between the active sites. In some bacteria, DHFR and TS genes are neighbors in the genome, whereas in others, they are located millions of base pairs apart. Gene neighboring gained importance in evolution because it was found to promote the interaction between expressed proteins in gene clusters. Co-expression of neighboring genes might favor protein associations, increasing the enzymatic efficiency. The basis of genomic evolution that leads to gene ordering is not totally understood; however, one could suppose that increasing the efficiency of metabolic pathways could work as an evolutionary pressure to get genes together in the genome of an organism. Approach: In this study, phylogenetic analysis of DHFR and TS sequences and the genomic distance between these genes in bacteria were measured. Results: No significant correlation was found between genomic distances, in base pairs, of DHFR and TS genes and phylogenetic distance among the studied bacteria. Conclusion/Recommendations: This suggested that DHFR and TS enzymes clusters, even if they are coexpressed, might not exert a pivotal role in natural selection of bacteria." @default.
- W2113229059 created "2016-06-24" @default.
- W2113229059 creator A5017188735 @default.
- W2113229059 date "2010-01-01" @default.
- W2113229059 modified "2023-09-29" @default.
- W2113229059 title "Genomic Distance between Thymidylate Synthase and Dihydrofolate Reductase Genes Does Not Correlate With Phylogenetic Evolution in Bacteria" @default.
- W2113229059 cites W1598176384 @default.
- W2113229059 cites W1974303275 @default.
- W2113229059 cites W1994345692 @default.
- W2113229059 cites W2009966494 @default.
- W2113229059 cites W2033832729 @default.
- W2113229059 cites W2053501576 @default.
- W2113229059 cites W2084902262 @default.
- W2113229059 cites W2106882534 @default.
- W2113229059 cites W2107424557 @default.
- W2113229059 cites W2121862891 @default.
- W2113229059 cites W2162407342 @default.
- W2113229059 doi "https://doi.org/10.3844/ajbbsp.2010.35.39" @default.
- W2113229059 hasPublicationYear "2010" @default.
- W2113229059 type Work @default.
- W2113229059 sameAs 2113229059 @default.
- W2113229059 citedByCount "1" @default.
- W2113229059 crossrefType "journal-article" @default.
- W2113229059 hasAuthorship W2113229059A5017188735 @default.
- W2113229059 hasBestOaLocation W21132290591 @default.
- W2113229059 hasConcept C104317684 @default.
- W2113229059 hasConcept C123321153 @default.
- W2113229059 hasConcept C141231307 @default.
- W2113229059 hasConcept C193252679 @default.
- W2113229059 hasConcept C2776694085 @default.
- W2113229059 hasConcept C2780456651 @default.
- W2113229059 hasConcept C2781320022 @default.
- W2113229059 hasConcept C54355233 @default.
- W2113229059 hasConcept C58431802 @default.
- W2113229059 hasConcept C86803240 @default.
- W2113229059 hasConceptScore W2113229059C104317684 @default.
- W2113229059 hasConceptScore W2113229059C123321153 @default.
- W2113229059 hasConceptScore W2113229059C141231307 @default.
- W2113229059 hasConceptScore W2113229059C193252679 @default.
- W2113229059 hasConceptScore W2113229059C2776694085 @default.
- W2113229059 hasConceptScore W2113229059C2780456651 @default.
- W2113229059 hasConceptScore W2113229059C2781320022 @default.
- W2113229059 hasConceptScore W2113229059C54355233 @default.
- W2113229059 hasConceptScore W2113229059C58431802 @default.
- W2113229059 hasConceptScore W2113229059C86803240 @default.
- W2113229059 hasIssue "1" @default.
- W2113229059 hasLocation W21132290591 @default.
- W2113229059 hasOpenAccess W2113229059 @default.
- W2113229059 hasPrimaryLocation W21132290591 @default.
- W2113229059 hasRelatedWork W1789563679 @default.
- W2113229059 hasRelatedWork W1974303275 @default.
- W2113229059 hasRelatedWork W1983111672 @default.
- W2113229059 hasRelatedWork W1994345692 @default.
- W2113229059 hasRelatedWork W2035454360 @default.
- W2113229059 hasRelatedWork W2059020601 @default.
- W2113229059 hasRelatedWork W2081200472 @default.
- W2113229059 hasRelatedWork W2113229059 @default.
- W2113229059 hasRelatedWork W2412736912 @default.
- W2113229059 hasRelatedWork W4240687535 @default.
- W2113229059 hasVolume "6" @default.
- W2113229059 isParatext "false" @default.
- W2113229059 isRetracted "false" @default.
- W2113229059 magId "2113229059" @default.
- W2113229059 workType "article" @default.