FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113229788> ?p ?o ?g. }

• W2113229788 endingPage "1112" @default.
• W2113229788 startingPage "1107" @default.
• W2113229788 abstract "The Strand-seq method independently sequences each parental strand of template DNA from single proliferating cells. It can be used to detect sister chromatid exchange and other chromosomal abnormalities at high resolution and to correct contig misorientations in genome assemblies, with potential for strand-inheritance and haplotyping studies. DNA rearrangements such as sister chromatid exchanges (SCEs) are sensitive indicators of genomic stress and instability, but they are typically masked by single-cell sequencing techniques. We developed Strand-seq to independently sequence parental DNA template strands from single cells, making it possible to map SCEs at orders-of-magnitude greater resolution than was previously possible. On average, murine embryonic stem (mES) cells exhibit eight SCEs, which are detected at a resolution of up to 23 bp. Strikingly, Strand-seq of 62 single mES cells predicts that the mm9 mouse reference genome assembly contains at least 17 incorrectly oriented segments totaling nearly 1% of the genome. These misoriented contigs and fragments have persisted through several iterations of the mouse reference genome and have been difficult to detect using conventional sequencing techniques. The ability to map SCE events at high resolution and fine-tune reference genomes by Strand-seq dramatically expands the scope of single-cell sequencing." @default.
• W2113229788 created "2016-06-24" @default.
• W2113229788 creator A5011681314 @default.
• W2113229788 creator A5023799679 @default.
• W2113229788 creator A5044232354 @default.
• W2113229788 creator A5044705149 @default.
• W2113229788 creator A5056104532 @default.
• W2113229788 creator A5066428428 @default.
• W2113229788 creator A5072313250 @default.
• W2113229788 creator A5078017283 @default.
• W2113229788 creator A5079350808 @default.
• W2113229788 date "2012-10-07" @default.
• W2113229788 modified "2023-10-18" @default.
• W2113229788 title "DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution" @default.
• W2113229788 cites W1964079648 @default.
• W2113229788 cites W1969112301 @default.
• W2113229788 cites W1971439600 @default.
• W2113229788 cites W1972603676 @default.
• W2113229788 cites W1986154799 @default.
• W2113229788 cites W1992118324 @default.
• W2113229788 cites W1996435746 @default.
• W2113229788 cites W2023560061 @default.
• W2113229788 cites W2027732925 @default.
• W2113229788 cites W2028069515 @default.
• W2113229788 cites W2030993769 @default.
• W2113229788 cites W2032518018 @default.
• W2113229788 cites W2037334278 @default.
• W2113229788 cites W2046463062 @default.
• W2113229788 cites W2049171639 @default.
• W2113229788 cites W2067466498 @default.
• W2113229788 cites W2073031672 @default.
• W2113229788 cites W2087242711 @default.
• W2113229788 cites W2095340238 @default.
• W2113229788 cites W2098152017 @default.
• W2113229788 cites W2100771513 @default.
• W2113229788 cites W2102619694 @default.
• W2113229788 cites W2103441770 @default.
• W2113229788 cites W2106897784 @default.
• W2113229788 cites W2108234281 @default.
• W2113229788 cites W2108698786 @default.
• W2113229788 cites W2109948920 @default.
• W2113229788 cites W2119440700 @default.
• W2113229788 cites W2128377922 @default.
• W2113229788 cites W2138041459 @default.
• W2113229788 cites W2140869203 @default.
• W2113229788 cites W2145968044 @default.
• W2113229788 cites W2153200875 @default.
• W2113229788 cites W2171053853 @default.
• W2113229788 doi "https://doi.org/10.1038/nmeth.2206" @default.
• W2113229788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3580294" @default.
• W2113229788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23042453" @default.
• W2113229788 hasPublicationYear "2012" @default.
• W2113229788 type Work @default.
• W2113229788 sameAs 2113229788 @default.
• W2113229788 citedByCount "155" @default.
• W2113229788 countsByYear W21132297882012 @default.
• W2113229788 countsByYear W21132297882013 @default.
• W2113229788 countsByYear W21132297882014 @default.
• W2113229788 countsByYear W21132297882015 @default.
• W2113229788 countsByYear W21132297882016 @default.
• W2113229788 countsByYear W21132297882017 @default.
• W2113229788 countsByYear W21132297882018 @default.
• W2113229788 countsByYear W21132297882019 @default.
• W2113229788 countsByYear W21132297882020 @default.
• W2113229788 countsByYear W21132297882021 @default.
• W2113229788 countsByYear W21132297882022 @default.
• W2113229788 countsByYear W21132297882023 @default.
• W2113229788 crossrefType "journal-article" @default.
• W2113229788 hasAuthorship W2113229788A5011681314 @default.
• W2113229788 hasAuthorship W2113229788A5023799679 @default.
• W2113229788 hasAuthorship W2113229788A5044232354 @default.
• W2113229788 hasAuthorship W2113229788A5044705149 @default.
• W2113229788 hasAuthorship W2113229788A5056104532 @default.
• W2113229788 hasAuthorship W2113229788A5066428428 @default.
• W2113229788 hasAuthorship W2113229788A5072313250 @default.
• W2113229788 hasAuthorship W2113229788A5078017283 @default.
• W2113229788 hasAuthorship W2113229788A5079350808 @default.
• W2113229788 hasBestOaLocation W21132297882 @default.
• W2113229788 hasConcept C104317684 @default.
• W2113229788 hasConcept C13575015 @default.
• W2113229788 hasConcept C141231307 @default.
• W2113229788 hasConcept C143425029 @default.
• W2113229788 hasConcept C178169997 @default.
• W2113229788 hasConcept C192953774 @default.
• W2113229788 hasConcept C2779071816 @default.
• W2113229788 hasConcept C3017666073 @default.
• W2113229788 hasConcept C30481170 @default.
• W2113229788 hasConcept C51679486 @default.
• W2113229788 hasConcept C54355233 @default.
• W2113229788 hasConcept C54887055 @default.
• W2113229788 hasConcept C552990157 @default.
• W2113229788 hasConcept C59582021 @default.
• W2113229788 hasConcept C70721500 @default.
• W2113229788 hasConcept C8502773 @default.
• W2113229788 hasConcept C86803240 @default.
• W2113229788 hasConceptScore W2113229788C104317684 @default.
• W2113229788 hasConceptScore W2113229788C13575015 @default.
• W2113229788 hasConceptScore W2113229788C141231307 @default.

• next