FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113229892> ?p ?o ?g. }

• W2113229892 endingPage "288" @default.
• W2113229892 startingPage "282" @default.
• W2113229892 abstract "Summary Background Cancer-testis antigens exemplify a growing number of tumour antigens which are expressed in a variety of malignancies, but not in normal tissues other than germ cells, primarily those of the testis. Objectives To investigate the humoral response to known cancer-testis antigens in melanoma patients. Methods We used phage clones coding for seven different melanoma antigens MAGE-A or LAGE-1A proteins. These clones were isolated using the newly developed DNA hybridization analysis of recombinantly expressed cDNA libraries (HYREX) approach. HYREX combines the advantage of a nonradioactive library screening method with the possibility of subsequently analysing the serological response to the recombinant proteins. We isolated clones coding for MAGE-A1, -A3, -A4b, -A6, -A9 and -A12, as well as LAGE-1A. Additionally, we correlated gene expression and seroreactivity. Results Between 13% and 27% of sera (n = 15) were reactive against individual tumour antigens. We found the presence of specific antibodies was, with only two exceptions, generally correlated with mRNA expression of the antigen within cell lines derived from the same patient. While cross-reactivity of patients' IgG might play a role in these cases, antibodies from patients' sera were able to distinguish even the closely related MAGE-A3 and -A6. In general, the mRNA expression frequency was higher than the detected IgG responses. Conclusions Antibody recognition of specific tumour antigens by patients' sera may be used for evaluating the possible immunogenicity of new antigens; serological tests could be used for tumour monitoring purposes." @default.
• W2113229892 created "2016-06-24" @default.
• W2113229892 creator A5023902940 @default.
• W2113229892 creator A5034365278 @default.
• W2113229892 creator A5051859452 @default.
• W2113229892 creator A5059121328 @default.
• W2113229892 date "2003-08-01" @default.
• W2113229892 modified "2023-09-28" @default.
• W2113229892 title "Seroreactivity against MAGE-A and LAGE-1 proteins in melanoma patients" @default.
• W2113229892 cites W1977297101 @default.
• W2113229892 cites W1984869659 @default.
• W2113229892 cites W1989150855 @default.
• W2113229892 cites W1992417360 @default.
• W2113229892 cites W2006987944 @default.
• W2113229892 cites W2007749743 @default.
• W2113229892 cites W2007865624 @default.
• W2113229892 cites W2010457947 @default.
• W2113229892 cites W2025309264 @default.
• W2113229892 cites W2026763255 @default.
• W2113229892 cites W2029778026 @default.
• W2113229892 cites W2032975856 @default.
• W2113229892 cites W2036392773 @default.
• W2113229892 cites W2037452525 @default.
• W2113229892 cites W2042174530 @default.
• W2113229892 cites W2056433735 @default.
• W2113229892 cites W2073252143 @default.
• W2113229892 cites W2074282467 @default.
• W2113229892 cites W2082732148 @default.
• W2113229892 cites W2096385955 @default.
• W2113229892 cites W2103990111 @default.
• W2113229892 cites W2124758160 @default.
• W2113229892 cites W2127468351 @default.
• W2113229892 cites W2130184077 @default.
• W2113229892 cites W2139894578 @default.
• W2113229892 cites W2141543852 @default.
• W2113229892 cites W2148564980 @default.
• W2113229892 cites W2161343890 @default.
• W2113229892 cites W2164658014 @default.
• W2113229892 cites W2165142928 @default.
• W2113229892 cites W4238811731 @default.
• W2113229892 cites W4241159546 @default.
• W2113229892 cites W4256534980 @default.
• W2113229892 doi "https://doi.org/10.1046/j.1365-2133.2003.05410.x" @default.
• W2113229892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12932233" @default.
• W2113229892 hasPublicationYear "2003" @default.
• W2113229892 type Work @default.
• W2113229892 sameAs 2113229892 @default.
• W2113229892 citedByCount "13" @default.
• W2113229892 countsByYear W21132298922013 @default.
• W2113229892 countsByYear W21132298922014 @default.
• W2113229892 countsByYear W21132298922017 @default.
• W2113229892 crossrefType "journal-article" @default.
• W2113229892 hasAuthorship W2113229892A5023902940 @default.
• W2113229892 hasAuthorship W2113229892A5034365278 @default.
• W2113229892 hasAuthorship W2113229892A5051859452 @default.
• W2113229892 hasAuthorship W2113229892A5059121328 @default.
• W2113229892 hasConcept C104317684 @default.
• W2113229892 hasConcept C147483822 @default.
• W2113229892 hasConcept C150194340 @default.
• W2113229892 hasConcept C153911025 @default.
• W2113229892 hasConcept C159047783 @default.
• W2113229892 hasConcept C159654299 @default.
• W2113229892 hasConcept C187882448 @default.
• W2113229892 hasConcept C189482833 @default.
• W2113229892 hasConcept C203014093 @default.
• W2113229892 hasConcept C2777658100 @default.
• W2113229892 hasConcept C2780868878 @default.
• W2113229892 hasConcept C40767141 @default.
• W2113229892 hasConcept C45189115 @default.
• W2113229892 hasConcept C502942594 @default.
• W2113229892 hasConcept C54355233 @default.
• W2113229892 hasConcept C86803240 @default.
• W2113229892 hasConceptScore W2113229892C104317684 @default.
• W2113229892 hasConceptScore W2113229892C147483822 @default.
• W2113229892 hasConceptScore W2113229892C150194340 @default.
• W2113229892 hasConceptScore W2113229892C153911025 @default.
• W2113229892 hasConceptScore W2113229892C159047783 @default.
• W2113229892 hasConceptScore W2113229892C159654299 @default.
• W2113229892 hasConceptScore W2113229892C187882448 @default.
• W2113229892 hasConceptScore W2113229892C189482833 @default.
• W2113229892 hasConceptScore W2113229892C203014093 @default.
• W2113229892 hasConceptScore W2113229892C2777658100 @default.
• W2113229892 hasConceptScore W2113229892C2780868878 @default.
• W2113229892 hasConceptScore W2113229892C40767141 @default.
• W2113229892 hasConceptScore W2113229892C45189115 @default.
• W2113229892 hasConceptScore W2113229892C502942594 @default.
• W2113229892 hasConceptScore W2113229892C54355233 @default.
• W2113229892 hasConceptScore W2113229892C86803240 @default.
• W2113229892 hasIssue "2" @default.
• W2113229892 hasLocation W21132298921 @default.
• W2113229892 hasLocation W21132298922 @default.
• W2113229892 hasOpenAccess W2113229892 @default.
• W2113229892 hasPrimaryLocation W21132298921 @default.
• W2113229892 hasRelatedWork W1530716184 @default.
• W2113229892 hasRelatedWork W1531528770 @default.
• W2113229892 hasRelatedWork W1973254433 @default.
• W2113229892 hasRelatedWork W2049946166 @default.
• W2113229892 hasRelatedWork W2165119471 @default.

• next