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- W2113231263 abstract "Zinc/clindamycin gel (Zindaclin® 1%) gel, is a new once‐daily topical acne treatment (Strakan Ltd) containing clindamycin phosphate equivalent to 1% clindamycin and zinc acetate in a formulation, which leads to a reduced systemic absorption of clindamycin through the skin. The objective of the study was to compare the systemic absorption of clindamycin from zinc/clindamycin gel and clindamycin lotion (Dalacin® T topical lotion, Pharmacia Ltd) after repeated twice‐daily topical administration for two periods of 5 days with an intervening gap of 2 weeks in 24 subjects with mild to moderate acne. Plasma Cmax, and AUC0‐12 of clindamycin measured after single and multiple applications of zinc/clindamycin gel were between 30% and 50% lower than for clindamycin lotion. As zinc/clindamycin gel is a topical treatment for acne, the lower systemic bioavailability may be beneficial because there may be a correspondingly lower risk of systemic events in zinc/clindamycin gel‐treated subjects." @default.
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- W2113231263 date "2006-01-01" @default.
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- W2113231263 title "A single centre, open‐label, cross‐over study of pharmacokinetics comparing topical zinc/clindamycin gel (Zindaclin®) and topical clindamycin lotion (Dalacin® T) in subjects with mild to moderate acne" @default.
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- W2113231263 doi "https://doi.org/10.1080/09546630600727115" @default.
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