FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113232287> ?p ?o ?g. }

• W2113232287 endingPage "1987" @default.
• W2113232287 startingPage "1980" @default.
• W2113232287 abstract "ABSTRACT Bioinformatics tools have the potential to accelerate research into the design of vaccines and diagnostic tests by exploiting genome sequences. The aim of this study was to assess whether in silico analysis could be combined with in vitro screening methods to rapidly identify peptides that are immunogenic during Mycobacterium bovis infection of cattle. In the first instance the M. bovis -derived protein ESAT-6 was used as a model antigen to describe peptides containing T-cell epitopes that were frequently recognized across mammalian species, including natural hosts for tuberculosis (humans and cattle) and small-animal models of tuberculosis (mice and guinea pigs). Having demonstrated that some peptides could be recognized by T cells from a number of M. bovis -infected hosts, we tested whether a virtual-matrix-based human prediction program (ProPred) could identify peptides that were recognized by T cells from M. bovis -infected cattle. In this study, 73% of the experimentally defined peptides from 10 M. bovis antigens that were recognized by bovine T cells contained motifs predicted by ProPred. Finally, in validating this observation, we showed that three of five peptides from the mycobacterial antigen Rv3019c that were predicted to contain HLA-DR-restricted epitopes were recognized by T cells from M. bovis -infected cattle. The results obtained in this study support the approach of using bioinformatics to increase the efficiency of epitope screening and selection." @default.
• W2113232287 created "2016-06-24" @default.
• W2113232287 creator A5066741823 @default.
• W2113232287 creator A5067493731 @default.
• W2113232287 creator A5091049534 @default.
• W2113232287 date "2003-04-01" @default.
• W2113232287 modified "2023-09-26" @default.
• W2113232287 title "Recognition of Mycobacterial Epitopes by T Cells across Mammalian Species and Use of a Program That Predicts Human HLA-DR Binding Peptides To Predict Bovine Epitopes" @default.
• W2113232287 cites W1486845428 @default.
• W2113232287 cites W1500118992 @default.
• W2113232287 cites W1973764984 @default.
• W2113232287 cites W1980744280 @default.
• W2113232287 cites W1987531965 @default.
• W2113232287 cites W2012591953 @default.
• W2113232287 cites W2018381639 @default.
• W2113232287 cites W2020646715 @default.
• W2113232287 cites W2021002908 @default.
• W2113232287 cites W2029472337 @default.
• W2113232287 cites W2035620466 @default.
• W2113232287 cites W2045018004 @default.
• W2113232287 cites W2055923826 @default.
• W2113232287 cites W2059853480 @default.
• W2113232287 cites W2060491151 @default.
• W2113232287 cites W2067211497 @default.
• W2113232287 cites W2075962065 @default.
• W2113232287 cites W2079129173 @default.
• W2113232287 cites W2079542677 @default.
• W2113232287 cites W2094056063 @default.
• W2113232287 cites W2097145871 @default.
• W2113232287 cites W2098988128 @default.
• W2113232287 cites W2104941073 @default.
• W2113232287 cites W2110424839 @default.
• W2113232287 cites W2113008350 @default.
• W2113232287 cites W2115809508 @default.
• W2113232287 cites W2118276840 @default.
• W2113232287 cites W2127558739 @default.
• W2113232287 cites W2127796418 @default.
• W2113232287 cites W2138647657 @default.
• W2113232287 cites W2142636897 @default.
• W2113232287 cites W2149350146 @default.
• W2113232287 cites W2157728001 @default.
• W2113232287 cites W2157882854 @default.
• W2113232287 cites W2158023121 @default.
• W2113232287 cites W2163167664 @default.
• W2113232287 cites W2167405605 @default.
• W2113232287 cites W2168466885 @default.
• W2113232287 cites W2168653518 @default.
• W2113232287 cites W2170035592 @default.
• W2113232287 cites W2178238560 @default.
• W2113232287 cites W2413885787 @default.
• W2113232287 doi "https://doi.org/10.1128/iai.71.4.1980-1987.2003" @default.
• W2113232287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/152066" @default.
• W2113232287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12654816" @default.
• W2113232287 hasPublicationYear "2003" @default.
• W2113232287 type Work @default.
• W2113232287 sameAs 2113232287 @default.
• W2113232287 citedByCount "58" @default.
• W2113232287 countsByYear W21132322872012 @default.
• W2113232287 countsByYear W21132322872013 @default.
• W2113232287 countsByYear W21132322872014 @default.
• W2113232287 countsByYear W21132322872016 @default.
• W2113232287 countsByYear W21132322872017 @default.
• W2113232287 countsByYear W21132322872018 @default.
• W2113232287 countsByYear W21132322872019 @default.
• W2113232287 countsByYear W21132322872023 @default.
• W2113232287 crossrefType "journal-article" @default.
• W2113232287 hasAuthorship W2113232287A5066741823 @default.
• W2113232287 hasAuthorship W2113232287A5067493731 @default.
• W2113232287 hasAuthorship W2113232287A5091049534 @default.
• W2113232287 hasBestOaLocation W21132322872 @default.
• W2113232287 hasConcept C104317684 @default.
• W2113232287 hasConcept C142724271 @default.
• W2113232287 hasConcept C147483822 @default.
• W2113232287 hasConcept C159047783 @default.
• W2113232287 hasConcept C188280979 @default.
• W2113232287 hasConcept C195616568 @default.
• W2113232287 hasConcept C203014093 @default.
• W2113232287 hasConcept C2775905019 @default.
• W2113232287 hasConcept C2777975735 @default.
• W2113232287 hasConcept C2778497218 @default.
• W2113232287 hasConcept C2781069245 @default.
• W2113232287 hasConcept C54355233 @default.
• W2113232287 hasConcept C70721500 @default.
• W2113232287 hasConcept C71924100 @default.
• W2113232287 hasConcept C86803240 @default.
• W2113232287 hasConceptScore W2113232287C104317684 @default.
• W2113232287 hasConceptScore W2113232287C142724271 @default.
• W2113232287 hasConceptScore W2113232287C147483822 @default.
• W2113232287 hasConceptScore W2113232287C159047783 @default.
• W2113232287 hasConceptScore W2113232287C188280979 @default.
• W2113232287 hasConceptScore W2113232287C195616568 @default.
• W2113232287 hasConceptScore W2113232287C203014093 @default.
• W2113232287 hasConceptScore W2113232287C2775905019 @default.
• W2113232287 hasConceptScore W2113232287C2777975735 @default.
• W2113232287 hasConceptScore W2113232287C2778497218 @default.
• W2113232287 hasConceptScore W2113232287C2781069245 @default.
• W2113232287 hasConceptScore W2113232287C54355233 @default.
• W2113232287 hasConceptScore W2113232287C70721500 @default.

• next