Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113237132> ?p ?o ?g. }
- W2113237132 endingPage "2384" @default.
- W2113237132 startingPage "2377" @default.
- W2113237132 abstract "Squamous cell carcinoma accounts for 20% of all human lung cancers and is strongly linked to cigarette smoking. It develops through premalignant changes that are characterized by high levels of keratin 14 (K14) expression in the airway epithelium and evolve through basal cell hyperplasia, squamous metaplasia and dysplasia to carcinoma in situ and invasive carcinoma. In order to explore the impact of K14 in the pulmonary epithelium that normally lacks both squamous differentiation and K14 expression, human keratin 14 gene hK14 was constitutively expressed in mouse airway progenitor cells using a mouse Clara cell specific 10 kDa protein (CC10) promoter. While the lungs of CC10-hK14 transgenic mice developed normally, we detected increased expression of K14 and the molecular markers of squamous differentiation program such as involucrin, loricrin, small proline-rich protein 1A, transglutaminase 1 and cholesterol sulfotransferase 2B1. In contrast, wild-type lungs were negative. Aging CC10-hK14 mice revealed multifocal airway cell hyperplasia, occasional squamous metaplasia and their lung tumors displayed evidence for multidirectional differentiation. We conclude that constitutive expression of hK14 initiates squamous differentiation program in the mouse lung, but fails to promote squamous maturation. Our study provides a novel model for assessing the mechanisms of premalignant lesions in vivo by modifying differentiation and proliferation of airway progenitor cells." @default.
- W2113237132 created "2016-06-24" @default.
- W2113237132 creator A5030043897 @default.
- W2113237132 creator A5035312513 @default.
- W2113237132 creator A5071714593 @default.
- W2113237132 date "2008-08-12" @default.
- W2113237132 modified "2023-10-02" @default.
- W2113237132 title "Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation" @default.
- W2113237132 cites W1518494853 @default.
- W2113237132 cites W1593127845 @default.
- W2113237132 cites W1604588480 @default.
- W2113237132 cites W2001323678 @default.
- W2113237132 cites W2004605070 @default.
- W2113237132 cites W2005630031 @default.
- W2113237132 cites W2013672234 @default.
- W2113237132 cites W2015977058 @default.
- W2113237132 cites W2016693266 @default.
- W2113237132 cites W2044240471 @default.
- W2113237132 cites W2052687680 @default.
- W2113237132 cites W2054924247 @default.
- W2113237132 cites W2063450941 @default.
- W2113237132 cites W2067746951 @default.
- W2113237132 cites W2070672125 @default.
- W2113237132 cites W2073526307 @default.
- W2113237132 cites W2073852580 @default.
- W2113237132 cites W2076358850 @default.
- W2113237132 cites W2084476589 @default.
- W2113237132 cites W2096122257 @default.
- W2113237132 cites W2099310552 @default.
- W2113237132 cites W2107277218 @default.
- W2113237132 cites W2111236583 @default.
- W2113237132 cites W2111360221 @default.
- W2113237132 cites W2115950166 @default.
- W2113237132 cites W2133006389 @default.
- W2113237132 cites W2134964552 @default.
- W2113237132 cites W2135838713 @default.
- W2113237132 cites W2137367185 @default.
- W2113237132 cites W2224929038 @default.
- W2113237132 cites W2322982840 @default.
- W2113237132 cites W2328558782 @default.
- W2113237132 cites W2576734941 @default.
- W2113237132 cites W35957379 @default.
- W2113237132 cites W4231054863 @default.
- W2113237132 cites W4250233718 @default.
- W2113237132 doi "https://doi.org/10.1093/carcin/bgn190" @default.
- W2113237132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2639248" @default.
- W2113237132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18701433" @default.
- W2113237132 hasPublicationYear "2008" @default.
- W2113237132 type Work @default.
- W2113237132 sameAs 2113237132 @default.
- W2113237132 citedByCount "29" @default.
- W2113237132 countsByYear W21132371322012 @default.
- W2113237132 countsByYear W21132371322013 @default.
- W2113237132 countsByYear W21132371322014 @default.
- W2113237132 countsByYear W21132371322015 @default.
- W2113237132 countsByYear W21132371322016 @default.
- W2113237132 countsByYear W21132371322017 @default.
- W2113237132 countsByYear W21132371322018 @default.
- W2113237132 countsByYear W21132371322019 @default.
- W2113237132 countsByYear W21132371322020 @default.
- W2113237132 countsByYear W21132371322021 @default.
- W2113237132 countsByYear W21132371322023 @default.
- W2113237132 crossrefType "journal-article" @default.
- W2113237132 hasAuthorship W2113237132A5030043897 @default.
- W2113237132 hasAuthorship W2113237132A5035312513 @default.
- W2113237132 hasAuthorship W2113237132A5071714593 @default.
- W2113237132 hasBestOaLocation W21132371321 @default.
- W2113237132 hasConcept C102230213 @default.
- W2113237132 hasConcept C104317684 @default.
- W2113237132 hasConcept C121608353 @default.
- W2113237132 hasConcept C134018914 @default.
- W2113237132 hasConcept C141035611 @default.
- W2113237132 hasConcept C142724271 @default.
- W2113237132 hasConcept C148738053 @default.
- W2113237132 hasConcept C170178370 @default.
- W2113237132 hasConcept C201750760 @default.
- W2113237132 hasConcept C2776008674 @default.
- W2113237132 hasConcept C2777546739 @default.
- W2113237132 hasConcept C2777562237 @default.
- W2113237132 hasConcept C2777577635 @default.
- W2113237132 hasConcept C2778266373 @default.
- W2113237132 hasConcept C2778981785 @default.
- W2113237132 hasConcept C2779357193 @default.
- W2113237132 hasConcept C28328180 @default.
- W2113237132 hasConcept C2994491419 @default.
- W2113237132 hasConcept C502942594 @default.
- W2113237132 hasConcept C50548948 @default.
- W2113237132 hasConcept C529295009 @default.
- W2113237132 hasConcept C54355233 @default.
- W2113237132 hasConcept C55493867 @default.
- W2113237132 hasConcept C555283112 @default.
- W2113237132 hasConcept C60870556 @default.
- W2113237132 hasConcept C71924100 @default.
- W2113237132 hasConcept C81241287 @default.
- W2113237132 hasConcept C86803240 @default.
- W2113237132 hasConcept C95444343 @default.
- W2113237132 hasConceptScore W2113237132C102230213 @default.
- W2113237132 hasConceptScore W2113237132C104317684 @default.