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• W2113237238 abstract "Approximately 10% of genes in the human genome are distributed such that their transcription start sites are located less than 1 kb apart on opposite strands. These divergent gene pairs have a single intergenic segment of DNA, which in some cases appears to share regulatory elements, but it is unclear whether these regions represent functional bidirectional promoters or two overlapping promoters. A recent study showed that divergent promoters are enriched for consensus binding sequences of a small group of transcription factors, including the ubiquitous ets-family transcription factor GA-binding protein (GABP). Here we show that GABP binds to more than 80% of divergent promoters in at least one cell type. Furthermore, we demonstrate that GABP binding is correlated and associated with bidirectional transcriptional activity in a luciferase transfection assay. In addition, we find that the addition of a strict consensus GABP site into a set of promoters that normally function in only one direction significantly increases activity in the opposite direction in 67% of cases. Our findings demonstrate that GABP regulates the majority of divergent promoters and suggest that bidirectional transcriptional activity is mediated through GABP binding and transactivation at both divergent and nondivergent promoters." @default.
• W2113237238 created "2016-06-24" @default.
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• W2113237238 date "2007-11-16" @default.
• W2113237238 modified "2023-10-06" @default.
• W2113237238 title "The ets-Related Transcription Factor GABP Directs Bidirectional Transcription" @default.
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• W2113237238 doi "https://doi.org/10.1371/journal.pgen.0030208" @default.
• W2113237238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2077898" @default.
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