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• W2113237744 abstract "Allotype and isotype exclusion is a property of most lymphocytes. The reason for this property is not known but it guarantees a high concentration of a single receptor, and threshold numbers of receptors may be required for efficient positive and negative selection. Receptor editing compromises exclusion by sustaining recombination even after a functional receptor is formed. Consequently, B cells expressing multiple receptors arise. We have studied such B cells in which one of the two receptors is anti-self, and find that these partially autoreactive B cells accumulate in the marginal zone. The restriction of these cells in this location may help to prevent them from undergoing diversification and developing into fully autoreactive B cells." @default.
• W2113237744 created "2016-06-24" @default.
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• W2113237744 creator A5006675915 @default.
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• W2113237744 date "2002-01-14" @default.
• W2113237744 modified "2023-09-30" @default.
• W2113237744 title "Autoreactive B Cells in the Marginal Zone that Express Dual Receptors" @default.
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• W2113237744 doi "https://doi.org/10.1084/jem.20011453" @default.
• W2113237744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193605" @default.
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