Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113241192> ?p ?o ?g. }
- W2113241192 endingPage "R398" @default.
- W2113241192 startingPage "R389" @default.
- W2113241192 abstract "Type A cholecystokinin receptor (CCKAR) antagonists differing in blood-brain barrier permeability were used to test the hypothesis that duodenal delivery of protein, carbohydrate, and fat produces satiety in part by an essential CCK action at CCKARs located peripheral to the blood-brain barrier. Fasted rats with open gastric fistulas received devazepide (1 mg/kg iv) or A-70104 (700 nmol · kg −1 · h −1 iv) and either a 30-min intravenous infusion of CCK-8 (10 nmol · kg −1 · h −1 ) or duodenal infusion of peptone, maltose, or Intralipid beginning 10 min before 30-min access to 15% sucrose. Devazepide penetrates the blood-brain barrier; A-70104, the dicyclohexylammonium salt of Nα-3-quinolinoyl-d-Glu- N,N-dipentylamide, does not. CCK-8 inhibited sham feeding by ∼50%, and both A-70104 and devazepide abolished this response. Duodenal infusion of each of the macronutrients dose dependently inhibited sham feeding. A-70104 and devazepide attenuated inhibitory responses to each macronutrient. Thus endogenous CCK appears to act in part at CCKARs peripheral to the blood-brain barrier to inhibit food intake." @default.
- W2113241192 created "2016-06-24" @default.
- W2113241192 creator A5041276328 @default.
- W2113241192 creator A5042147358 @default.
- W2113241192 creator A5046634711 @default.
- W2113241192 creator A5048181700 @default.
- W2113241192 date "2003-02-01" @default.
- W2113241192 modified "2023-10-09" @default.
- W2113241192 title "Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats" @default.
- W2113241192 cites W1825291712 @default.
- W2113241192 cites W1861428614 @default.
- W2113241192 cites W1876036557 @default.
- W2113241192 cites W1913424663 @default.
- W2113241192 cites W1948259501 @default.
- W2113241192 cites W1968858188 @default.
- W2113241192 cites W1971699667 @default.
- W2113241192 cites W1972554285 @default.
- W2113241192 cites W1978984434 @default.
- W2113241192 cites W1981192436 @default.
- W2113241192 cites W1993866430 @default.
- W2113241192 cites W2000812693 @default.
- W2113241192 cites W2001292573 @default.
- W2113241192 cites W2001399503 @default.
- W2113241192 cites W2008627119 @default.
- W2113241192 cites W2013590024 @default.
- W2113241192 cites W2013808037 @default.
- W2113241192 cites W2019850048 @default.
- W2113241192 cites W2022541536 @default.
- W2113241192 cites W2024756267 @default.
- W2113241192 cites W2027259035 @default.
- W2113241192 cites W2029364850 @default.
- W2113241192 cites W2033219511 @default.
- W2113241192 cites W2034139274 @default.
- W2113241192 cites W2035731700 @default.
- W2113241192 cites W2037826839 @default.
- W2113241192 cites W2038445494 @default.
- W2113241192 cites W2038915304 @default.
- W2113241192 cites W2044774793 @default.
- W2113241192 cites W2047851671 @default.
- W2113241192 cites W2051282023 @default.
- W2113241192 cites W2052006481 @default.
- W2113241192 cites W2059990910 @default.
- W2113241192 cites W2061840198 @default.
- W2113241192 cites W2063597674 @default.
- W2113241192 cites W2071928653 @default.
- W2113241192 cites W2087513888 @default.
- W2113241192 cites W2093710794 @default.
- W2113241192 cites W2102863957 @default.
- W2113241192 cites W2115913020 @default.
- W2113241192 cites W2118898496 @default.
- W2113241192 cites W2119153622 @default.
- W2113241192 cites W2122856478 @default.
- W2113241192 cites W2134867426 @default.
- W2113241192 cites W2136268118 @default.
- W2113241192 cites W2153111625 @default.
- W2113241192 cites W2215608440 @default.
- W2113241192 cites W2220578648 @default.
- W2113241192 cites W2232115551 @default.
- W2113241192 cites W2235203115 @default.
- W2113241192 cites W2243311102 @default.
- W2113241192 cites W2256831100 @default.
- W2113241192 cites W2278329867 @default.
- W2113241192 cites W2283361844 @default.
- W2113241192 cites W2285985516 @default.
- W2113241192 cites W2286322790 @default.
- W2113241192 cites W2291368943 @default.
- W2113241192 cites W2296811425 @default.
- W2113241192 cites W2334987227 @default.
- W2113241192 cites W2397617032 @default.
- W2113241192 cites W4241468533 @default.
- W2113241192 cites W4249956946 @default.
- W2113241192 cites W4255319040 @default.
- W2113241192 cites W91898450 @default.
- W2113241192 doi "https://doi.org/10.1152/ajpregu.00529.2002" @default.
- W2113241192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12414437" @default.
- W2113241192 hasPublicationYear "2003" @default.
- W2113241192 type Work @default.
- W2113241192 sameAs 2113241192 @default.
- W2113241192 citedByCount "39" @default.
- W2113241192 countsByYear W21132411922012 @default.
- W2113241192 countsByYear W21132411922013 @default.
- W2113241192 countsByYear W21132411922014 @default.
- W2113241192 countsByYear W21132411922015 @default.
- W2113241192 countsByYear W21132411922017 @default.
- W2113241192 countsByYear W21132411922018 @default.
- W2113241192 countsByYear W21132411922021 @default.
- W2113241192 crossrefType "journal-article" @default.
- W2113241192 hasAuthorship W2113241192A5041276328 @default.
- W2113241192 hasAuthorship W2113241192A5042147358 @default.
- W2113241192 hasAuthorship W2113241192A5046634711 @default.
- W2113241192 hasAuthorship W2113241192A5048181700 @default.
- W2113241192 hasConcept C126322002 @default.
- W2113241192 hasConcept C134018914 @default.
- W2113241192 hasConcept C170493617 @default.
- W2113241192 hasConcept C185592680 @default.
- W2113241192 hasConcept C2776297358 @default.
- W2113241192 hasConcept C2777593968 @default.
- W2113241192 hasConcept C2778395965 @default.