FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113241480> ?p ?o ?g. }

• W2113241480 endingPage "11113" @default.
• W2113241480 startingPage "11108" @default.
• W2113241480 abstract "The Sgs1 protein of the budding yeast Saccharomyces cerevisiae is a member of the RecQ DNA helicase family that includes the human Bloom, Werner, and Rothmund-Thompson syndrome proteins. The N-terminal region outside the central DNA helicase core of Sgs1, particularly the part containing the first 100 amino acid residues of the 1,447-residue protein, is known to be functionally important and has been implicated in Sgs1-DNA topoisomerase III (Top3) interaction. We show in this work that the functionality of a truncated Sgs1 lacking its N-terminal 106 residues can be restored by replacing the truncated region with Top3. Fusion of Top3 to a mutant Sgs1 with a Val-29 to Glu substitution, which interferes with Sgs1-Top3 interaction, similarly restores the functionality of the mutant Sgs1(V29E) protein. The Top3-Sgs1(Delta1-106) and Top3-Sgs1(V29E) fusion proteins behave like wild-type Sgs1 in complementing several aspects of the sgs1 phenotype, including the hypersensitivity of sgs1 cells to methyl methanesulfonate and hydroxyurea. Complementation by the fusion proteins required both the topoisomerase activity of Top3 and the helicase activity of the Sgs1 polypeptide. These results suggest that the sole function of the N-terminal 106 amino acid residues of Sgs1 is for Top3 binding, and that the coordinated actions of Sgs1 and Top3 are important in cellular processes such as the processing of DNA after exposure of cells to DNA-damaging agents." @default.
• W2113241480 created "2016-06-24" @default.
• W2113241480 creator A5011866089 @default.
• W2113241480 creator A5073689309 @default.
• W2113241480 date "2001-09-11" @default.
• W2113241480 modified "2023-09-25" @default.
• W2113241480 title "Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: Studies of fusion proteins" @default.
• W2113241480 cites W1523619671 @default.
• W2113241480 cites W1541526229 @default.
• W2113241480 cites W1565890429 @default.
• W2113241480 cites W1870502238 @default.
• W2113241480 cites W1926322311 @default.
• W2113241480 cites W1935801587 @default.
• W2113241480 cites W1952829170 @default.
• W2113241480 cites W1963578989 @default.
• W2113241480 cites W1967390330 @default.
• W2113241480 cites W1970898019 @default.
• W2113241480 cites W1973674463 @default.
• W2113241480 cites W1977518145 @default.
• W2113241480 cites W1989971670 @default.
• W2113241480 cites W1994944745 @default.
• W2113241480 cites W1996542243 @default.
• W2113241480 cites W2001193188 @default.
• W2113241480 cites W2023563387 @default.
• W2113241480 cites W2025294101 @default.
• W2113241480 cites W2025519738 @default.
• W2113241480 cites W2031184810 @default.
• W2113241480 cites W2035378579 @default.
• W2113241480 cites W2038535143 @default.
• W2113241480 cites W2039674107 @default.
• W2113241480 cites W2039996950 @default.
• W2113241480 cites W2046144388 @default.
• W2113241480 cites W2049160479 @default.
• W2113241480 cites W2055182100 @default.
• W2113241480 cites W2064310741 @default.
• W2113241480 cites W2073483575 @default.
• W2113241480 cites W2078502658 @default.
• W2113241480 cites W2079322632 @default.
• W2113241480 cites W2082557856 @default.
• W2113241480 cites W2085081661 @default.
• W2113241480 cites W2093785124 @default.
• W2113241480 cites W2108172001 @default.
• W2113241480 cites W2109714973 @default.
• W2113241480 cites W2112594892 @default.
• W2113241480 cites W2112746887 @default.
• W2113241480 cites W2129225238 @default.
• W2113241480 cites W2131704410 @default.
• W2113241480 cites W2136081950 @default.
• W2113241480 cites W2138034994 @default.
• W2113241480 cites W2142168955 @default.
• W2113241480 cites W2143632094 @default.
• W2113241480 cites W2158140981 @default.
• W2113241480 cites W2161650693 @default.
• W2113241480 cites W2168545181 @default.
• W2113241480 cites W4236394930 @default.
• W2113241480 cites W4236530034 @default.
• W2113241480 cites W4237820381 @default.
• W2113241480 doi "https://doi.org/10.1073/pnas.201387098" @default.
• W2113241480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/58691" @default.
• W2113241480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11553789" @default.
• W2113241480 hasPublicationYear "2001" @default.
• W2113241480 type Work @default.
• W2113241480 sameAs 2113241480 @default.
• W2113241480 citedByCount "39" @default.
• W2113241480 countsByYear W21132414802013 @default.
• W2113241480 countsByYear W21132414802018 @default.
• W2113241480 crossrefType "journal-article" @default.
• W2113241480 hasAuthorship W2113241480A5011866089 @default.
• W2113241480 hasAuthorship W2113241480A5073689309 @default.
• W2113241480 hasBestOaLocation W21132414801 @default.
• W2113241480 hasConcept C104317684 @default.
• W2113241480 hasConcept C143425029 @default.
• W2113241480 hasConcept C153911025 @default.
• W2113241480 hasConcept C161223559 @default.
• W2113241480 hasConcept C178169997 @default.
• W2113241480 hasConcept C2777576037 @default.
• W2113241480 hasConcept C2779222958 @default.
• W2113241480 hasConcept C2780751114 @default.
• W2113241480 hasConcept C552990157 @default.
• W2113241480 hasConcept C55493867 @default.
• W2113241480 hasConcept C67705224 @default.
• W2113241480 hasConcept C86803240 @default.
• W2113241480 hasConceptScore W2113241480C104317684 @default.
• W2113241480 hasConceptScore W2113241480C143425029 @default.
• W2113241480 hasConceptScore W2113241480C153911025 @default.
• W2113241480 hasConceptScore W2113241480C161223559 @default.
• W2113241480 hasConceptScore W2113241480C178169997 @default.
• W2113241480 hasConceptScore W2113241480C2777576037 @default.
• W2113241480 hasConceptScore W2113241480C2779222958 @default.
• W2113241480 hasConceptScore W2113241480C2780751114 @default.
• W2113241480 hasConceptScore W2113241480C552990157 @default.
• W2113241480 hasConceptScore W2113241480C55493867 @default.
• W2113241480 hasConceptScore W2113241480C67705224 @default.
• W2113241480 hasConceptScore W2113241480C86803240 @default.
• W2113241480 hasIssue "20" @default.
• W2113241480 hasLocation W21132414801 @default.
• W2113241480 hasLocation W21132414802 @default.
• W2113241480 hasLocation W21132414803 @default.

• next