FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113241752> ?p ?o ?g. }

• W2113241752 endingPage "89" @default.
• W2113241752 startingPage "79" @default.
• W2113241752 abstract "Multiwalled carbon nanotubes (MWCNT) are one of the most commonly produced nanomaterials, and pulmonary exposure during production, use, and disposal is a concern for the developing nanotechnology field. The airway epithelium is the first line of defense against inhaled particles. In a mouse model, MWCNT were reported to reach the alveolar space of the lung after in vivo exposure, penetrate the epithelial lining, and result in inflammation and progressive fibrosis. This study sought to determine the cellular and gene expression changes in small airway epithelial cells (SAEC) after in vitro exposure to MWCNT in an effort to elucidate potential toxicity mechanisms and signaling pathways. A direct interaction between SAEC and MWCNT was confirmed by both internalization of MWCNT and interaction at the cell periphery. Following exposure, SAEC showed time-dependent increases in reactive oxygen species production, total protein phosphotyrosine and phosphothreonine levels, and migratory behavior. Analysis of gene and protein expression suggested altered regulation of multiple biomarkers of lung damage, carcinogenesis, and tumor progression, as well as genes involved in related signaling pathways. These results demonstrate that MWCNT exposure resulted in the activation of SAEC. Gene expression data derived from MWCNT exposure provide information that may be used to elucidate the underlying mode of action of MWCNT in the small airway and suggest potential prognostic gene signatures for risk assessment." @default.
• W2113241752 created "2016-06-24" @default.
• W2113241752 creator A5005188785 @default.
• W2113241752 creator A5005777618 @default.
• W2113241752 creator A5006031913 @default.
• W2113241752 creator A5018197555 @default.
• W2113241752 creator A5046283873 @default.
• W2113241752 creator A5052054327 @default.
• W2113241752 creator A5072867312 @default.
• W2113241752 creator A5075066992 @default.
• W2113241752 date "2013-02-01" @default.
• W2113241752 modified "2023-09-23" @default.
• W2113241752 title "Systematic Analysis of Multiwalled Carbon Nanotube-Induced Cellular Signaling and Gene Expression in Human Small Airway Epithelial Cells" @default.
• W2113241752 cites W1965902122 @default.
• W2113241752 cites W1978232781 @default.
• W2113241752 cites W1979072219 @default.
• W2113241752 cites W1980843814 @default.
• W2113241752 cites W1988773132 @default.
• W2113241752 cites W1988896491 @default.
• W2113241752 cites W1989704479 @default.
• W2113241752 cites W1994062800 @default.
• W2113241752 cites W1997301858 @default.
• W2113241752 cites W1999064578 @default.
• W2113241752 cites W2011913041 @default.
• W2113241752 cites W2018858346 @default.
• W2113241752 cites W2027037439 @default.
• W2113241752 cites W2032689481 @default.
• W2113241752 cites W2032831754 @default.
• W2113241752 cites W2043877786 @default.
• W2113241752 cites W2046315474 @default.
• W2113241752 cites W2055519466 @default.
• W2113241752 cites W2068500323 @default.
• W2113241752 cites W2074016471 @default.
• W2113241752 cites W2076629995 @default.
• W2113241752 cites W2090290628 @default.
• W2113241752 cites W2107205997 @default.
• W2113241752 cites W2117326659 @default.
• W2113241752 cites W2119596974 @default.
• W2113241752 cites W2125851698 @default.
• W2113241752 cites W2128976939 @default.
• W2113241752 cites W2144674981 @default.
• W2113241752 cites W2152447806 @default.
• W2113241752 cites W2160275284 @default.
• W2113241752 cites W2162089683 @default.
• W2113241752 cites W2166278470 @default.
• W2113241752 doi "https://doi.org/10.1093/toxsci/kft019" @default.
• W2113241752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3627550" @default.
• W2113241752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23377615" @default.
• W2113241752 hasPublicationYear "2013" @default.
• W2113241752 type Work @default.
• W2113241752 sameAs 2113241752 @default.
• W2113241752 citedByCount "29" @default.
• W2113241752 countsByYear W21132417522013 @default.
• W2113241752 countsByYear W21132417522014 @default.
• W2113241752 countsByYear W21132417522015 @default.
• W2113241752 countsByYear W21132417522016 @default.
• W2113241752 countsByYear W21132417522017 @default.
• W2113241752 countsByYear W21132417522018 @default.
• W2113241752 countsByYear W21132417522019 @default.
• W2113241752 countsByYear W21132417522022 @default.
• W2113241752 crossrefType "journal-article" @default.
• W2113241752 hasAuthorship W2113241752A5005188785 @default.
• W2113241752 hasAuthorship W2113241752A5005777618 @default.
• W2113241752 hasAuthorship W2113241752A5006031913 @default.
• W2113241752 hasAuthorship W2113241752A5018197555 @default.
• W2113241752 hasAuthorship W2113241752A5046283873 @default.
• W2113241752 hasAuthorship W2113241752A5052054327 @default.
• W2113241752 hasAuthorship W2113241752A5072867312 @default.
• W2113241752 hasAuthorship W2113241752A5075066992 @default.
• W2113241752 hasBestOaLocation W21132417522 @default.
• W2113241752 hasConcept C104317684 @default.
• W2113241752 hasConcept C139770010 @default.
• W2113241752 hasConcept C1491633281 @default.
• W2113241752 hasConcept C150194340 @default.
• W2113241752 hasConcept C185592680 @default.
• W2113241752 hasConcept C55493867 @default.
• W2113241752 hasConcept C555283112 @default.
• W2113241752 hasConcept C62478195 @default.
• W2113241752 hasConcept C86803240 @default.
• W2113241752 hasConcept C95444343 @default.
• W2113241752 hasConceptScore W2113241752C104317684 @default.
• W2113241752 hasConceptScore W2113241752C139770010 @default.
• W2113241752 hasConceptScore W2113241752C1491633281 @default.
• W2113241752 hasConceptScore W2113241752C150194340 @default.
• W2113241752 hasConceptScore W2113241752C185592680 @default.
• W2113241752 hasConceptScore W2113241752C55493867 @default.
• W2113241752 hasConceptScore W2113241752C555283112 @default.
• W2113241752 hasConceptScore W2113241752C62478195 @default.
• W2113241752 hasConceptScore W2113241752C86803240 @default.
• W2113241752 hasConceptScore W2113241752C95444343 @default.
• W2113241752 hasIssue "1" @default.
• W2113241752 hasLocation W21132417521 @default.
• W2113241752 hasLocation W21132417522 @default.
• W2113241752 hasLocation W21132417523 @default.
• W2113241752 hasLocation W21132417524 @default.
• W2113241752 hasOpenAccess W2113241752 @default.
• W2113241752 hasPrimaryLocation W21132417521 @default.
• W2113241752 hasRelatedWork W1987603245 @default.

• next