FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113243052> ?p ?o ?g. }

• W2113243052 endingPage "714" @default.
• W2113243052 startingPage "709" @default.
• W2113243052 abstract "This study describes effects of various peptides, neurotransmitters and cyclic nucleotides on brain polyphosphoinositide metabolism in vitro. The interconversion of the polyanionic inositol phospholipids was studied by incubation of a lysed crude mitochondrial/synaptosomal fraction with [gamma-32P]-ATP. The reference peptide ACTH1-24 stimulated the formation of radiolabelled phosphatidylinositol 4,5-diphosphate (TPI) and inhibited that of phosphatidic acid (PA). Substance P inhibited both TPI and PA labelling, whereas beta-endorphin inhibited that of PA without any effect on TPI. Morphine had no effect at any concentration tested, whereas high concentrations of naloxone inhibited the labelling of both PA and TPI. Naloxone did not counteract the effects of ACTH1-24. The other peptides tested (lysine 8-vasopressin and angiotensin II) were without any effect. Under the conditions used, adrenaline, noradrenaline and acetylcholine did not affect the labelling of the (poly)phosphoinositides. Both dopamine and serotonin, however, dose-dependently inhibited the formation of radiolabelled TPI and PA. Low concentrations of cAMP stimulated TPI, but higher concentrations had an overall inhibitory effect on the labelling of TPI, PA and especially phosphatidylinositol 4-phosphate (DPI). The cyclic nucleotide did not mediate or counteract the effects of ACTH, and cGMP was without any effect. These results are discussed in the light of current ideas on the mechanism of action of neuropeptides." @default.
• W2113243052 created "2016-06-24" @default.
• W2113243052 creator A5031359251 @default.
• W2113243052 creator A5046064430 @default.
• W2113243052 creator A5047061438 @default.
• W2113243052 creator A5061769645 @default.
• W2113243052 date "1982-09-01" @default.
• W2113243052 modified "2023-10-14" @default.
• W2113243052 title "Polyphosphoinositide metabolism in rat brain: Effects of neuropeptides, neurotransmitters and cyclic nucleotides" @default.
• W2113243052 cites W1491005627 @default.
• W2113243052 cites W1759002262 @default.
• W2113243052 cites W1775749144 @default.
• W2113243052 cites W1970038583 @default.
• W2113243052 cites W1971842245 @default.
• W2113243052 cites W1973087356 @default.
• W2113243052 cites W1973412254 @default.
• W2113243052 cites W1976411251 @default.
• W2113243052 cites W1979575564 @default.
• W2113243052 cites W1980278427 @default.
• W2113243052 cites W1984835099 @default.
• W2113243052 cites W1991684639 @default.
• W2113243052 cites W1993931435 @default.
• W2113243052 cites W1994401612 @default.
• W2113243052 cites W2004798951 @default.
• W2113243052 cites W2016264629 @default.
• W2113243052 cites W2023700569 @default.
• W2113243052 cites W2025059572 @default.
• W2113243052 cites W2032318679 @default.
• W2113243052 cites W2040030902 @default.
• W2113243052 cites W2054404646 @default.
• W2113243052 cites W2075289127 @default.
• W2113243052 cites W2077313103 @default.
• W2113243052 cites W2128164253 @default.
• W2113243052 cites W2138064654 @default.
• W2113243052 cites W2139687001 @default.
• W2113243052 cites W2141201970 @default.
• W2113243052 cites W2157379321 @default.
• W2113243052 cites W2170223225 @default.
• W2113243052 cites W2336165323 @default.
• W2113243052 cites W2344419281 @default.
• W2113243052 doi "https://doi.org/10.1016/0196-9781(82)90002-x" @default.
• W2113243052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6129617" @default.
• W2113243052 hasPublicationYear "1982" @default.
• W2113243052 type Work @default.
• W2113243052 sameAs 2113243052 @default.
• W2113243052 citedByCount "11" @default.
• W2113243052 crossrefType "journal-article" @default.
• W2113243052 hasAuthorship W2113243052A5031359251 @default.
• W2113243052 hasAuthorship W2113243052A5046064430 @default.
• W2113243052 hasAuthorship W2113243052A5047061438 @default.
• W2113243052 hasAuthorship W2113243052A5061769645 @default.
• W2113243052 hasBestOaLocation W21132430522 @default.
• W2113243052 hasConcept C104317684 @default.
• W2113243052 hasConcept C118303440 @default.
• W2113243052 hasConcept C11960822 @default.
• W2113243052 hasConcept C126322002 @default.
• W2113243052 hasConcept C134018914 @default.
• W2113243052 hasConcept C163235415 @default.
• W2113243052 hasConcept C170493617 @default.
• W2113243052 hasConcept C181199279 @default.
• W2113243052 hasConcept C185592680 @default.
• W2113243052 hasConcept C2776370428 @default.
• W2113243052 hasConcept C2776909261 @default.
• W2113243052 hasConcept C2777427919 @default.
• W2113243052 hasConcept C2778524494 @default.
• W2113243052 hasConcept C2778618036 @default.
• W2113243052 hasConcept C2778750930 @default.
• W2113243052 hasConcept C2778918659 @default.
• W2113243052 hasConcept C2780523633 @default.
• W2113243052 hasConcept C2780610907 @default.
• W2113243052 hasConcept C2781063702 @default.
• W2113243052 hasConcept C41625074 @default.
• W2113243052 hasConcept C512185932 @default.
• W2113243052 hasConcept C55493867 @default.
• W2113243052 hasConcept C71924100 @default.
• W2113243052 hasConcept C86803240 @default.
• W2113243052 hasConceptScore W2113243052C104317684 @default.
• W2113243052 hasConceptScore W2113243052C118303440 @default.
• W2113243052 hasConceptScore W2113243052C11960822 @default.
• W2113243052 hasConceptScore W2113243052C126322002 @default.
• W2113243052 hasConceptScore W2113243052C134018914 @default.
• W2113243052 hasConceptScore W2113243052C163235415 @default.
• W2113243052 hasConceptScore W2113243052C170493617 @default.
• W2113243052 hasConceptScore W2113243052C181199279 @default.
• W2113243052 hasConceptScore W2113243052C185592680 @default.
• W2113243052 hasConceptScore W2113243052C2776370428 @default.
• W2113243052 hasConceptScore W2113243052C2776909261 @default.
• W2113243052 hasConceptScore W2113243052C2777427919 @default.
• W2113243052 hasConceptScore W2113243052C2778524494 @default.
• W2113243052 hasConceptScore W2113243052C2778618036 @default.
• W2113243052 hasConceptScore W2113243052C2778750930 @default.
• W2113243052 hasConceptScore W2113243052C2778918659 @default.
• W2113243052 hasConceptScore W2113243052C2780523633 @default.
• W2113243052 hasConceptScore W2113243052C2780610907 @default.
• W2113243052 hasConceptScore W2113243052C2781063702 @default.
• W2113243052 hasConceptScore W2113243052C41625074 @default.
• W2113243052 hasConceptScore W2113243052C512185932 @default.
• W2113243052 hasConceptScore W2113243052C55493867 @default.

• next