FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113243306> ?p ?o ?g. }

• W2113243306 endingPage "2045" @default.
• W2113243306 startingPage "2037" @default.
• W2113243306 abstract "The aim of this study was to test the hypothesis that late potentials and fractionated electrogram activity are due to delayed depolarization within the anterior aspects of right ventricular (RV) epicardium in experimental models of Brugada syndrome (BrS). Clinical reports have demonstrated late potentials on signal-averaged electrocardiography (ECG) recorded in patients with BrS. Recent studies report the appearance of late potentials and fractionated activity on bipolar electrograms recorded in the epicardium of the RV outflow tract in patients with BrS. Action potential and bipolar electrograms were recorded at epicardial and endocardial sites of coronary-perfused canine RV wedge preparations, together with a pseudo-ECG. The transient outward potassium current agonist NS5806 (5 μM) and the Ca2+-channel blocker verapamil (2 μM) were used to pharmacologically mimic the BrS genetic defect. Fractionated electrical activity was observed in RV epicardium, but not in endocardium, as a consequence of heterogeneities in the appearance of the second upstroke of the epicardial action potential, and discrete high-frequency spikes developed as a result of concealed phase 2 re-entry. In no case did we observe primary conduction delay as the cause of the BrS ECG phenotype or of late potential or fractionated electrogram activity. Quinidine (10 μM) and the phosphodiesterase-3 inhibitors cilostazol (10 μM) and milrinone (2.5 μM) restored electrical homogeneity, thus abolishing all late potentials and fractionated electrical activity. These data point to an alternative pathophysiological basis for late potentials and fractionated electrical activity recorded in the right ventricle in the setting of BrS. We demonstrate an association of such activity with abnormal repolarization and not with abnormal depolarization or structural abnormalities." @default.
• W2113243306 created "2016-06-24" @default.
• W2113243306 creator A5005749391 @default.
• W2113243306 creator A5026903300 @default.
• W2113243306 date "2014-05-01" @default.
• W2113243306 modified "2023-10-11" @default.
• W2113243306 title "Abnormal Repolarization as the Basis for Late Potentials and Fractionated Electrograms Recorded From Epicardium in Experimental Models of Brugada Syndrome" @default.
• W2113243306 cites W1491803208 @default.
• W2113243306 cites W1586581147 @default.
• W2113243306 cites W1968876226 @default.
• W2113243306 cites W1970345729 @default.
• W2113243306 cites W1977361379 @default.
• W2113243306 cites W1987428270 @default.
• W2113243306 cites W2003646765 @default.
• W2113243306 cites W2011574040 @default.
• W2113243306 cites W2020787350 @default.
• W2113243306 cites W2044873676 @default.
• W2113243306 cites W2065840258 @default.
• W2113243306 cites W2075685281 @default.
• W2113243306 cites W2083714051 @default.
• W2113243306 cites W2085994359 @default.
• W2113243306 cites W2089861793 @default.
• W2113243306 cites W2091723996 @default.
• W2113243306 cites W2110639216 @default.
• W2113243306 cites W2119568772 @default.
• W2113243306 cites W2122455147 @default.
• W2113243306 cites W2132318327 @default.
• W2113243306 cites W2133897256 @default.
• W2113243306 cites W2140332009 @default.
• W2113243306 cites W2142550975 @default.
• W2113243306 cites W2143470172 @default.
• W2113243306 cites W2145544373 @default.
• W2113243306 cites W2149134234 @default.
• W2113243306 cites W2149802022 @default.
• W2113243306 cites W2150145251 @default.
• W2113243306 cites W2151232306 @default.
• W2113243306 cites W2158378828 @default.
• W2113243306 cites W2162209435 @default.
• W2113243306 cites W220488953 @default.
• W2113243306 cites W4210965788 @default.
• W2113243306 doi "https://doi.org/10.1016/j.jacc.2014.01.067" @default.
• W2113243306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4024366" @default.
• W2113243306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24657694" @default.
• W2113243306 hasPublicationYear "2014" @default.
• W2113243306 type Work @default.
• W2113243306 sameAs 2113243306 @default.
• W2113243306 citedByCount "99" @default.
• W2113243306 countsByYear W21132433062014 @default.
• W2113243306 countsByYear W21132433062015 @default.
• W2113243306 countsByYear W21132433062016 @default.
• W2113243306 countsByYear W21132433062017 @default.
• W2113243306 countsByYear W21132433062018 @default.
• W2113243306 countsByYear W21132433062019 @default.
• W2113243306 countsByYear W21132433062020 @default.
• W2113243306 countsByYear W21132433062021 @default.
• W2113243306 countsByYear W21132433062022 @default.
• W2113243306 countsByYear W21132433062023 @default.
• W2113243306 crossrefType "journal-article" @default.
• W2113243306 hasAuthorship W2113243306A5005749391 @default.
• W2113243306 hasAuthorship W2113243306A5026903300 @default.
• W2113243306 hasBestOaLocation W21132433061 @default.
• W2113243306 hasConcept C101404756 @default.
• W2113243306 hasConcept C126322002 @default.
• W2113243306 hasConcept C146403970 @default.
• W2113243306 hasConcept C147944092 @default.
• W2113243306 hasConcept C164705383 @default.
• W2113243306 hasConcept C185263204 @default.
• W2113243306 hasConcept C2777022698 @default.
• W2113243306 hasConcept C2777382798 @default.
• W2113243306 hasConcept C2777463368 @default.
• W2113243306 hasConcept C2778921608 @default.
• W2113243306 hasConcept C2780040984 @default.
• W2113243306 hasConcept C519063684 @default.
• W2113243306 hasConcept C71924100 @default.
• W2113243306 hasConcept C85378888 @default.
• W2113243306 hasConceptScore W2113243306C101404756 @default.
• W2113243306 hasConceptScore W2113243306C126322002 @default.
• W2113243306 hasConceptScore W2113243306C146403970 @default.
• W2113243306 hasConceptScore W2113243306C147944092 @default.
• W2113243306 hasConceptScore W2113243306C164705383 @default.
• W2113243306 hasConceptScore W2113243306C185263204 @default.
• W2113243306 hasConceptScore W2113243306C2777022698 @default.
• W2113243306 hasConceptScore W2113243306C2777382798 @default.
• W2113243306 hasConceptScore W2113243306C2777463368 @default.
• W2113243306 hasConceptScore W2113243306C2778921608 @default.
• W2113243306 hasConceptScore W2113243306C2780040984 @default.
• W2113243306 hasConceptScore W2113243306C519063684 @default.
• W2113243306 hasConceptScore W2113243306C71924100 @default.
• W2113243306 hasConceptScore W2113243306C85378888 @default.
• W2113243306 hasFunder F4320313691 @default.
• W2113243306 hasFunder F4320337338 @default.
• W2113243306 hasIssue "19" @default.
• W2113243306 hasLocation W21132433061 @default.
• W2113243306 hasLocation W21132433062 @default.
• W2113243306 hasLocation W21132433063 @default.
• W2113243306 hasLocation W21132433064 @default.
• W2113243306 hasLocation W21132433065 @default.
• W2113243306 hasOpenAccess W2113243306 @default.

• next